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Determination of sodium fusidate in dosage forms by high performance liquid chromatography

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Authors
Vladimirov, S
Ivanisević, L
Agbaba, Danica
Brborić, Jasmina
Živanov-Stakić, Dobrila
Article (Published version)
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Abstract
A simple HPLC procedure, suitable for the determination of sodium fusidate (SF) in dosage forms, was developed. The method involves using a UV detector (208 nm) in the presence of basic buffered media (pH 7.25) under reversed-phase conditions (Supelcosil(R) LC18(TM), 3 mu m particles). The linear regression between the concentration of SF and the peak area, y = -4.4566 + 8.9238x with a coefficient of correlation r = 0.9985, was confirmed for SF in the concentration range from 25 mu g/ml to 150 mu g/ml. The detection limit of SF was 12.5 mu g/ml. The HPLC method was applied for the determination of SF in dosage forms: Stanicid(R) coated tablets, Stanicid(R) ointment and Stanicid(R) sterile gauze dressing. The concentrations and statistical parameters of sodium fusidate for all the investigated dosage forms were satisfactory and ranged from 100.41 to 105.39% (the R. S. D. ranged from 1.51 to 2.75%).
Keywords:
Dosage forms / Raw material / Rp-HPLC / Sodium fusidate / UV-detection
Source:
Journal of the Serbian Chemical Society, 1998, 63, 6, 475-480
Publisher:
  • Srpsko hemijsko društvo, Beograd

ISSN: 0352-5139

WoS: 000073978300009

Scopus: 2-s2.0-0039346902
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/184
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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