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The influence of aging and estradiol to progesterone ratio on rat macrophage phenotypic profile and NO and TNF-alpha production

Само за регистроване кориснике
2013
Аутори
Dimitrijević, Mirjana
Stanojević, Stanislava
Kustrimović, Nataša
Mitić, Katarina
Vujić, Vesna
Aleksić, Iva
Radojević, Katarina
Leposavić, Gordana
Чланак у часопису (Објављена верзија)
Метаподаци
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Апстракт
The phenotype and function of tissue macrophages substantially depend on the cellular milieu and biological effector molecules, such as steroid hormones, to which they are exposed. Furthermore, in female rats, aging is associated with the altered macrophage functioning and the increased estrogen level is followed by a decrease in that of progesterone. Therefore, the present study aimed to investigate the influence of estradiol/progesterone balance on rat macrophage function and phenotype throughout whole adult lifespan. We ovariectomized rats at the late prepubertal age or at the very end of reproductive lifespan, and examined the expression of ED2 (CD163, a marker of mature resident macrophages related to secretion of inflammatory mediators) on peritoneal macrophages and their ability to produce TNF-alpha and NO upon LPS-stimulation at different age points. In addition, to delineate direct and indirect effects of estrogen, we assessed the in vitro influence of different concentrations... of 17 beta-estradiol on LPS-induced macrophage TNF-alpha and NO production. Results showed that: ( a) the low frequency of ED2(high) cells amongst peritoneal macrophages of aged rats was accompanied with the reduced TNF-alpha, but not NO production; (b) estradiol level gradually increased following ovariectomy;

Кључне речи:
Aging / Estradiol/progesterone balance / Macrophages / TNF-alpha / NO / Rat
Извор:
Experimental Gerontology, 2013, 48, 11, 1243-1254
Издавач:
  • Pergamon-Elsevier Science Ltd, Oxford
Пројекти:
  • Пластичност имунског система током старења: имуномодулаторни потенцијал естрогена (RS-175050)

DOI: 10.1016/j.exger.2013.07.001

ISSN: 0531-5565

PubMed: 23850866

WoS: 000325750900014

Scopus: 2-s2.0-84883649839
[ Google Scholar ]
12
11
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1840
Колекције
  • Radovi istraživača / Researchers’ publications
Институција
Pharmacy

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