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dc.creatorMiletić, Tijana
dc.creatorKyriakos, Kachrimanis
dc.creatorGraovac, Adrijana
dc.creatorIbrić, Svetlana
dc.date.accessioned2019-09-02T11:32:21Z
dc.date.available2019-09-02T11:32:21Z
dc.date.issued2013
dc.identifier.issn0144-8617
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1841
dc.description.abstractThe present work investigates the effect of complexation with hydroxypropyl-beta-cyclodextrin (HPBCD) and 2-O-methyl-beta-cyclodextrin (2-O-MBCD), on voriconazole solubility, dissolution rate and chemical stability. Drug-cyclodextrin complexes were prepared as aqueous solutions, which were spray-dried, and their properties were compared to wet ground samples and physical mixtures. DSC analysis revealed absence of crystalline voriconazole from spray-dried complexes. FTIR spectroscopy indicated changes in the H-bonding network of the hydroxyl groups of cyclodextrin following drug inclusion. Dissolution rate of voriconazole was significantly higher from spray-dried complexes with either cyclodextrin in comparison with free drug, physical mixtures, or wet ground mixtures. However, two degradation impurities were found in aged samples, with slightly higher impurity level with HPBCD. Performed solubility studies suggested that 2-O-MBCD is more efficient solubilizer. Molecular docking simulations showed a difference in the 1:1 binding affinities and sites, with HPBCD surprisingly forming complexes of much lower energy, thus suggesting a multiple rather than a 1:1 complexation.en
dc.publisherElsevier Sci Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsrestrictedAccess
dc.sourceCarbohydrate Polymers
dc.subjectVoriconazoleen
dc.subjectCyclodextrinsen
dc.subjectSolubilityen
dc.subjectDissolutionen
dc.subjectStabilityen
dc.subjectMolecular dockingen
dc.titleSpray-dried voriconazole-cyclodextrin complexes: Solubility, dissolution rate and chemical stabilityen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГраовац, Aдријана; Кyриакос, Кацхриманис; Милетић, Тијана; Ибрић, Светлана;
dc.citation.volume98
dc.citation.issue1
dc.citation.spage122
dc.citation.epage131
dc.citation.other98(1): 122-131
dc.citation.rankaM21
dc.identifier.wos000325835600016
dc.identifier.doi10.1016/j.carbpol.2013.05.084
dc.identifier.pmid23987325
dc.identifier.scopus2-s2.0-84879493192
dc.identifier.rcubconv_2935
dc.type.versionpublishedVersion


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