Objectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 +/- 12.23 years with different kidney diseases over three years after kidney biopsy. Materials and Methods. Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later Results. Significantly positive correlations between tissue KIM-1 expression and age (r = 0.313), TIN inflammation (r = 0.456), fibrosis (r = 0.317), and proteinuria at 6 months (r = 0.394) as well as negative correlations with GFR0 (r = -0.572), GFR6 (r = -0.442), GFR24 (r = -0.398), and GFR36 (r = -0.412) were found. Meanwhile, TIN inflammation was the best predictor of all m...easured kidney functions during three years, while tissue KIM-1 expression (p = 0.016) was a predictor only at 6 months after biopsy. Conclusion. Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.
TY - JOUR
AU - Simić-Ogrizović, Sanja
AU - Bojić, Suzana
AU - Basta-Jovanović, Gordana
AU - Radojević, Sanja
AU - Pavlović, Jelena
AU - Kotur-Stevuljević, Jelena
AU - Dopsaj, Violeta
AU - Naumović, Radomir
PY - 2013
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1842
AB - Objectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 +/- 12.23 years with different kidney diseases over three years after kidney biopsy. Materials and Methods. Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later Results. Significantly positive correlations between tissue KIM-1 expression and age (r = 0.313), TIN inflammation (r = 0.456), fibrosis (r = 0.317), and proteinuria at 6 months (r = 0.394) as well as negative correlations with GFR0 (r = -0.572), GFR6 (r = -0.442), GFR24 (r = -0.398), and GFR36 (r = -0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (p = 0.016) was a predictor only at 6 months after biopsy. Conclusion. Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.
PB - Hindawi Publishing Corporation, New York
T2 - Disease Markers
T1 - Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy
SP - 567
EP - 572
DO - 10.1155/2013/183246
ER -
@article{
author = "Simić-Ogrizović, Sanja and Bojić, Suzana and Basta-Jovanović, Gordana and Radojević, Sanja and Pavlović, Jelena and Kotur-Stevuljević, Jelena and Dopsaj, Violeta and Naumović, Radomir",
year = "2013",
abstract = "Objectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 +/- 12.23 years with different kidney diseases over three years after kidney biopsy. Materials and Methods. Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later Results. Significantly positive correlations between tissue KIM-1 expression and age (r = 0.313), TIN inflammation (r = 0.456), fibrosis (r = 0.317), and proteinuria at 6 months (r = 0.394) as well as negative correlations with GFR0 (r = -0.572), GFR6 (r = -0.442), GFR24 (r = -0.398), and GFR36 (r = -0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (p = 0.016) was a predictor only at 6 months after biopsy. Conclusion. Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.",
publisher = "Hindawi Publishing Corporation, New York",
journal = "Disease Markers",
title = "Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy",
pages = "567-572",
doi = "10.1155/2013/183246"
}
Simić-Ogrizović, S., Bojić, S., Basta-Jovanović, G., Radojević, S., Pavlović, J., Kotur-Stevuljević, J., Dopsaj, V.,& Naumović, R.. (2013). Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy. in Disease Markers
Hindawi Publishing Corporation, New York., 567-572.
https://doi.org/10.1155/2013/183246
Simić-Ogrizović S, Bojić S, Basta-Jovanović G, Radojević S, Pavlović J, Kotur-Stevuljević J, Dopsaj V, Naumović R. Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy. in Disease Markers. 2013;:567-572.
doi:10.1155/2013/183246 .
Simić-Ogrizović, Sanja, Bojić, Suzana, Basta-Jovanović, Gordana, Radojević, Sanja, Pavlović, Jelena, Kotur-Stevuljević, Jelena, Dopsaj, Violeta, Naumović, Radomir, "Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy" in Disease Markers (2013):567-572,
https://doi.org/10.1155/2013/183246 . .
