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dc.creatorSimić-Ogrizović, Sanja
dc.creatorBojić, Suzana
dc.creatorBasta-Jovanović, Gordana
dc.creatorRadojević, Sanja
dc.creatorPavlović, Jelena
dc.creatorKotur-Stevuljević, Jelena
dc.creatorDopsaj, Violeta
dc.creatorNaumović, Radomir
dc.date.accessioned2019-09-02T11:32:22Z
dc.date.available2019-09-02T11:32:22Z
dc.date.issued2013
dc.identifier.issn0278-0240
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1842
dc.description.abstractObjectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 +/- 12.23 years with different kidney diseases over three years after kidney biopsy. Materials and Methods. Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later Results. Significantly positive correlations between tissue KIM-1 expression and age (r = 0.313), TIN inflammation (r = 0.456), fibrosis (r = 0.317), and proteinuria at 6 months (r = 0.394) as well as negative correlations with GFR0 (r = -0.572), GFR6 (r = -0.442), GFR24 (r = -0.398), and GFR36 (r = -0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (p = 0.016) was a predictor only at 6 months after biopsy. Conclusion. Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.en
dc.publisherHindawi Publishing Corporation, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175089/RS//
dc.rightsopenAccess
dc.sourceDisease Markers
dc.titleTissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsyen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractДопсај, Виолета; Павловић, Јелена; Котур-Стевуљевић, Јелена; Симић-Огризовић, Сања; Наумовић, Радомир; Бојић, Сузана; Баста-Јовановић, Гордана; Радојевић, Сања;
dc.citation.spage567
dc.citation.epage572
dc.citation.other: 567-572
dc.citation.rankM22
dc.identifier.wos000326537100001
dc.identifier.doi10.1155/2013/183246
dc.identifier.pmid24282337
dc.identifier.scopus2-s2.0-84890422684
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/640/1840.pdf
dc.identifier.rcubconv_2948
dc.type.versionpublishedVersion


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