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Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients

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2013
1857.pdf (1.218Mb)
Authors
Memon, Lidija
Spasojević-Kalimanovska, Vesna
Bogavac-Stanojević, Nataša
Kotur-Stevuljević, Jelena
Simić-Ogrizović, Sanja
Giga, Vojislav
Dopsaj, Violeta
Jelić-Ivanović, Zorana
Spasić, Slavica
Article (Published version)
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Abstract
Objectives. The study was designed to evaluate associations between symmetric dimethylarginine (SDMA), inflammation, and superoxide anion (O-2(center dot-)) with endothelial function and to determine their potential for screening of endothelial dysfunction in patients with chronic kidney disease (CKD) and renal transplant (RT) recipients. Materials and Methods. We included 64 CKD and 52 RT patients. Patients were stratified according to brachial artery flow-mediated dilation (FMD). Results. Logistic regression analysis showed that high SDMA and high sensitive C-reactive protein (hs-CRP) were associated with impaired FMD in CKD and RT patients, after adjustment for glomerular filtration rate. The ability of inflammation, SDMA, and O-2(center dot-) to detect impaired FMD was investigated by receiving operative characteristic analysis. Hs-CRP (area under the curves (AUC) = 0.754, P lt 0.001), IL-6 (AUC = 0.699, P = 0.002), and SDMA (AUC = 0.689, P = 0.007) had the highest ability to det...ect impaired FMD. SDMA in combination with inflammatory parameters and/or O-2(center dot-) had better screening performance than SDMA alone. Conclusions. Our results indicate a strong predictable association between hs-CRP, SDMA, and endothelial dysfunction in CKD patients and RT recipients. The individual marker that showed the strongest discriminative ability for endothelial dysfunction is hs-CRP, but its usefulness as a discriminatory marker for efficient diagnosis of endothelial dysfunction should be examined in prospective studies.

Source:
Disease Markers, 2013, 173-180
Publisher:
  • Hindawi Ltd, London
Funding / projects:
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)

DOI: 10.1155/2013/306908

ISSN: 0278-0240

PubMed: 24167363

WoS: 000323983000001

Scopus: 2-s2.0-84884227584
[ Google Scholar ]
10
10
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1859
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Memon, Lidija
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Kotur-Stevuljević, Jelena
AU  - Simić-Ogrizović, Sanja
AU  - Giga, Vojislav
AU  - Dopsaj, Violeta
AU  - Jelić-Ivanović, Zorana
AU  - Spasić, Slavica
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1859
AB  - Objectives. The study was designed to evaluate associations between symmetric dimethylarginine (SDMA), inflammation, and superoxide anion (O-2(center dot-)) with endothelial function and to determine their potential for screening of endothelial dysfunction in patients with chronic kidney disease (CKD) and renal transplant (RT) recipients. Materials and Methods. We included 64 CKD and 52 RT patients. Patients were stratified according to brachial artery flow-mediated dilation (FMD). Results. Logistic regression analysis showed that high SDMA and high sensitive C-reactive protein (hs-CRP) were associated with impaired FMD in CKD and RT patients, after adjustment for glomerular filtration rate. The ability of inflammation, SDMA, and O-2(center dot-) to detect impaired FMD was investigated by receiving operative characteristic analysis. Hs-CRP (area under the curves (AUC) = 0.754, P  lt  0.001), IL-6 (AUC = 0.699, P = 0.002), and SDMA (AUC = 0.689, P = 0.007) had the highest ability to detect impaired FMD. SDMA in combination with inflammatory parameters and/or O-2(center dot-) had better screening performance than SDMA alone. Conclusions. Our results indicate a strong predictable association between hs-CRP, SDMA, and endothelial dysfunction in CKD patients and RT recipients. The individual marker that showed the strongest discriminative ability for endothelial dysfunction is hs-CRP, but its usefulness as a discriminatory marker for efficient diagnosis of endothelial dysfunction should be examined in prospective studies.
PB  - Hindawi Ltd, London
T2  - Disease Markers
T1  - Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients
SP  - 173
EP  - 180
DO  - 10.1155/2013/306908
ER  - 
@article{
author = "Memon, Lidija and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Kotur-Stevuljević, Jelena and Simić-Ogrizović, Sanja and Giga, Vojislav and Dopsaj, Violeta and Jelić-Ivanović, Zorana and Spasić, Slavica",
year = "2013",
abstract = "Objectives. The study was designed to evaluate associations between symmetric dimethylarginine (SDMA), inflammation, and superoxide anion (O-2(center dot-)) with endothelial function and to determine their potential for screening of endothelial dysfunction in patients with chronic kidney disease (CKD) and renal transplant (RT) recipients. Materials and Methods. We included 64 CKD and 52 RT patients. Patients were stratified according to brachial artery flow-mediated dilation (FMD). Results. Logistic regression analysis showed that high SDMA and high sensitive C-reactive protein (hs-CRP) were associated with impaired FMD in CKD and RT patients, after adjustment for glomerular filtration rate. The ability of inflammation, SDMA, and O-2(center dot-) to detect impaired FMD was investigated by receiving operative characteristic analysis. Hs-CRP (area under the curves (AUC) = 0.754, P  lt  0.001), IL-6 (AUC = 0.699, P = 0.002), and SDMA (AUC = 0.689, P = 0.007) had the highest ability to detect impaired FMD. SDMA in combination with inflammatory parameters and/or O-2(center dot-) had better screening performance than SDMA alone. Conclusions. Our results indicate a strong predictable association between hs-CRP, SDMA, and endothelial dysfunction in CKD patients and RT recipients. The individual marker that showed the strongest discriminative ability for endothelial dysfunction is hs-CRP, but its usefulness as a discriminatory marker for efficient diagnosis of endothelial dysfunction should be examined in prospective studies.",
publisher = "Hindawi Ltd, London",
journal = "Disease Markers",
title = "Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients",
pages = "173-180",
doi = "10.1155/2013/306908"
}
Memon, L., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Kotur-Stevuljević, J., Simić-Ogrizović, S., Giga, V., Dopsaj, V., Jelić-Ivanović, Z.,& Spasić, S.. (2013). Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients. in Disease Markers
Hindawi Ltd, London., 173-180.
https://doi.org/10.1155/2013/306908
Memon L, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Kotur-Stevuljević J, Simić-Ogrizović S, Giga V, Dopsaj V, Jelić-Ivanović Z, Spasić S. Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients. in Disease Markers. 2013;:173-180.
doi:10.1155/2013/306908 .
Memon, Lidija, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Kotur-Stevuljević, Jelena, Simić-Ogrizović, Sanja, Giga, Vojislav, Dopsaj, Violeta, Jelić-Ivanović, Zorana, Spasić, Slavica, "Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients" in Disease Markers (2013):173-180,
https://doi.org/10.1155/2013/306908 . .

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