Total bilirubin in young men and women: Association with risk markers for cardiovascular diseases
Samo za registrovane korisnike
2013
Autori
Stojanov, MarinaStefanović, Aleksandra
Dzingalasević, Gordana
Ivanišević, Jasmina
Miljković, Milica
Mandić-Radić, Slavka
Prostran, Milica
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Objective: The aim of this study was to investigate whether high bilirubin concentration is a protective factor in cardiovascular disease (CAD) and how it correlates with parameters of oxidative stress in young males and females. Methods: The study comprised 628 healthy subjects of both genders, 18-22 years of age. In fasting sera the concentration of total bilirubin (Tbil), parameters of cardiovascular risk and oxidative stress were determined. The results were analyzed by appropriate statistical methods. Results: We found no gender differences in body mass index (BMI), blood pressure and lipid profile between subjects with low and high Tbil level. Men with high Tbil had higher concentrations of albumin and uric acid (p lt 0.001) and lower of oxLDL ( lt 0.05), while women had higher albumin (p lt 0.05) and lower TBARS (p lt 0.05). Significant positive correlation in men was found between Tbil, uric acid and albumin, while for glucose and TSARS this association was negative. In fe...male significant positive correlation was between Tbil, HDL-C, fibrinogen, albumin and uric acid and negative between Tbil and TBARS. The high concentration of Tbil in men was independently associated with uric acid (p lt 0.05) and oxLDL (p lt 0.001), while in women it was independently associated with TBARS (p lt 0.05). After adjustment for traditional lipid parameters the predictive power of high bilirubin in men remained for uric acid (p lt 0.001) and TBARS in women (p lt 0.05). Conclusion: These findings jointly support the concept that bilirubin via its antioxidant potential has a protective effect against cardiovascular disease in young male and female.
Ključne reči:
Bilirubin / Cardiovascular diseases / Reactive oxygen species / oxLDLIzvor:
Clinical Biochemistry, 2013, 46, 15, 1516-1519Izdavač:
- Pergamon-Elsevier Science Ltd, Oxford
Finansiranje / projekti:
DOI: 10.1016/j.clinbiochem.2013.06.020
ISSN: 0009-9120
PubMed: 23827733
WoS: 000325056300032
Scopus: 2-s2.0-84884351238
Institucija/grupa
PharmacyTY - JOUR AU - Stojanov, Marina AU - Stefanović, Aleksandra AU - Dzingalasević, Gordana AU - Ivanišević, Jasmina AU - Miljković, Milica AU - Mandić-Radić, Slavka AU - Prostran, Milica PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1862 AB - Objective: The aim of this study was to investigate whether high bilirubin concentration is a protective factor in cardiovascular disease (CAD) and how it correlates with parameters of oxidative stress in young males and females. Methods: The study comprised 628 healthy subjects of both genders, 18-22 years of age. In fasting sera the concentration of total bilirubin (Tbil), parameters of cardiovascular risk and oxidative stress were determined. The results were analyzed by appropriate statistical methods. Results: We found no gender differences in body mass index (BMI), blood pressure and lipid profile between subjects with low and high Tbil level. Men with high Tbil had higher concentrations of albumin and uric acid (p lt 0.001) and lower of oxLDL ( lt 0.05), while women had higher albumin (p lt 0.05) and lower TBARS (p lt 0.05). Significant positive correlation in men was found between Tbil, uric acid and albumin, while for glucose and TSARS this association was negative. In female significant positive correlation was between Tbil, HDL-C, fibrinogen, albumin and uric acid and negative between Tbil and TBARS. The high concentration of Tbil in men was independently associated with uric acid (p lt 0.05) and oxLDL (p lt 0.001), while in women it was independently associated with TBARS (p lt 0.05). After adjustment for traditional lipid parameters the predictive power of high bilirubin in men remained for uric acid (p lt 0.001) and TBARS in women (p lt 0.05). Conclusion: These findings jointly support the concept that bilirubin via its antioxidant potential has a protective effect against cardiovascular disease in young male and female. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Clinical Biochemistry T1 - Total bilirubin in young men and women: Association with risk markers for cardiovascular diseases VL - 46 IS - 15 SP - 1516 EP - 1519 DO - 10.1016/j.clinbiochem.2013.06.020 ER -
@article{ author = "Stojanov, Marina and Stefanović, Aleksandra and Dzingalasević, Gordana and Ivanišević, Jasmina and Miljković, Milica and Mandić-Radić, Slavka and Prostran, Milica", year = "2013", abstract = "Objective: The aim of this study was to investigate whether high bilirubin concentration is a protective factor in cardiovascular disease (CAD) and how it correlates with parameters of oxidative stress in young males and females. Methods: The study comprised 628 healthy subjects of both genders, 18-22 years of age. In fasting sera the concentration of total bilirubin (Tbil), parameters of cardiovascular risk and oxidative stress were determined. The results were analyzed by appropriate statistical methods. Results: We found no gender differences in body mass index (BMI), blood pressure and lipid profile between subjects with low and high Tbil level. Men with high Tbil had higher concentrations of albumin and uric acid (p lt 0.001) and lower of oxLDL ( lt 0.05), while women had higher albumin (p lt 0.05) and lower TBARS (p lt 0.05). Significant positive correlation in men was found between Tbil, uric acid and albumin, while for glucose and TSARS this association was negative. In female significant positive correlation was between Tbil, HDL-C, fibrinogen, albumin and uric acid and negative between Tbil and TBARS. The high concentration of Tbil in men was independently associated with uric acid (p lt 0.05) and oxLDL (p lt 0.001), while in women it was independently associated with TBARS (p lt 0.05). After adjustment for traditional lipid parameters the predictive power of high bilirubin in men remained for uric acid (p lt 0.001) and TBARS in women (p lt 0.05). Conclusion: These findings jointly support the concept that bilirubin via its antioxidant potential has a protective effect against cardiovascular disease in young male and female.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Clinical Biochemistry", title = "Total bilirubin in young men and women: Association with risk markers for cardiovascular diseases", volume = "46", number = "15", pages = "1516-1519", doi = "10.1016/j.clinbiochem.2013.06.020" }
Stojanov, M., Stefanović, A., Dzingalasević, G., Ivanišević, J., Miljković, M., Mandić-Radić, S.,& Prostran, M.. (2013). Total bilirubin in young men and women: Association with risk markers for cardiovascular diseases. in Clinical Biochemistry Pergamon-Elsevier Science Ltd, Oxford., 46(15), 1516-1519. https://doi.org/10.1016/j.clinbiochem.2013.06.020
Stojanov M, Stefanović A, Dzingalasević G, Ivanišević J, Miljković M, Mandić-Radić S, Prostran M. Total bilirubin in young men and women: Association with risk markers for cardiovascular diseases. in Clinical Biochemistry. 2013;46(15):1516-1519. doi:10.1016/j.clinbiochem.2013.06.020 .
Stojanov, Marina, Stefanović, Aleksandra, Dzingalasević, Gordana, Ivanišević, Jasmina, Miljković, Milica, Mandić-Radić, Slavka, Prostran, Milica, "Total bilirubin in young men and women: Association with risk markers for cardiovascular diseases" in Clinical Biochemistry, 46, no. 15 (2013):1516-1519, https://doi.org/10.1016/j.clinbiochem.2013.06.020 . .