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dc.creatorHadžifejzović, Nihad
dc.creatorKukić-Marković, Jelena
dc.creatorPetrović, Silvana
dc.creatorSoković, Marina
dc.creatorGlamočlija, Jasmina
dc.creatorStojković, Dejan
dc.creatorNahrstedt, Adolf
dc.date.accessioned2019-09-02T11:32:57Z
dc.date.available2019-09-02T11:32:57Z
dc.date.issued2013
dc.identifier.issn0926-6690
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1866
dc.description.abstractHere we report on the antimicrobial and antioxidant activity of several extracts of Ruscus aculeatus L. and Ruscus hypoglossum L., as well as of some compounds previously isolated from them (p-coumaric and caffeic acids, rutin). For antimicrobial activity, the microdilution technique was used against eight bacterial and five fungal strains, along with standard drugs (streptomycin, ampicillin, bifonazole, ketoconazole). Investigated extracts and isolated compounds showed antibacterial and especially antifungal activity. In some cases this activity was better than standard drugs (streptomycin, ampicillin, bifonazole, ketoconazole) and was more evident for some of isolated compounds. Antioxidant activity was investigated by DPPH and 2-deoxyribose assays, along with spectrophotometrical determination of total phenolics content (TPC) using Folin-Ciocalteu reagent. In DPPH test obtained SC50 values were in a range of 173-541 mu g/mL, while inhibition of 2-deoxyribose for some extracts reached up to maximal 50%. Results of antioxidant assays were strongly correlated with total phenolics content. The most active was the EtOAc fraction of the MeOH extract of R. aculeatus herb regarding all investigated parameters.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173021/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173032/RS//
dc.rightsrestrictedAccess
dc.sourceIndustrial Crops and Products
dc.subjectRuscus aculeatusen
dc.subjectRuscus hypoglossumen
dc.subjectRuscaceaeen
dc.subjectAntimicrobial activityen
dc.subjectAntioxidant activityen
dc.titleBioactivity of the extracts and compounds of Ruscus aculeatus L. and Ruscus hypoglossum L.en
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтојковић, Дејан; Кукић-Марковић, Јелена; Хадзфејзовић, Нихад; Нахрстедт, Aдолф; Петровић, Силвана; Соковић, Марина; Гламочлија, Јасмина;
dc.citation.volume49
dc.citation.spage407
dc.citation.epage411
dc.citation.other49: 407-411
dc.citation.rankM21a
dc.identifier.wos000324566600056
dc.identifier.doi10.1016/j.indcrop.2013.05.036
dc.identifier.scopus2-s2.0-84879559294
dc.identifier.rcubconv_2915
dc.type.versionpublishedVersion


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