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dc.creatorRadovanović, Ana M.
dc.creatorCupara, Snežana
dc.creatorPopović, Suzana L. J.
dc.creatorTomović, Marina T.
dc.creatorSlavkovska, Violeta
dc.creatorJanković, Slobodan
dc.date.accessioned2019-09-02T11:33:03Z
dc.date.available2019-09-02T11:33:03Z
dc.date.issued2013
dc.identifier.issn0001-6837
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1869
dc.description.abstractPotentilla reptans L. belongs to the least studied of the plants from Rosaceae family, Potentilla genus. There are no data on cytotoxicity of P. reptans extracts, though traditionaly it was used as anti-inflammatory and antiinfective. The aim of these studies was to investigate potential antitumor activity of aqueous extracts (rhizome and aerial parts) of P. reptans on 4T1 mouse breast cancer cell line._Aqueous extracts of rhizome and aerial parts of P. reptans were tested for cytotoxicity by the MTT colorimetric assay on 4T1 cancer cell line in concentration range 100-800 mu g/mL. Aqueous extracts of P. reptans rhizome and aerial parts show concentration dependent cytotoxic effect in the range of tested concentrations. IC50 value of P. reptans rhizome extract was 280.51 +/- 1.16 mu g/mL. IC50 value of P. reptans aerial parts extract was 310.79 +/- 1.22 mu g/mL. The significant difference in cytotoxicity among tested concentrations was observed. Aqueous extracts of P. mptans rhizome and aerial parts demonstrated weak cytotoxic activity on 4T1 mouse breast cancer cell line, which is in correlation with current cytotoxicity data for aqueous herbal extracts. Rhizome extract of P. reptans has slightly higher antitumor activity than aerial parts extract. The results represent the first report on cytotoxicity for this plant and further research on human cell lines is indicated.en
dc.publisherPolskie Towarzystwo Farmaceutyczne, Warsaw
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175014/RS//
dc.rightsopenAccess
dc.sourceActa Poloniae Pharmaceutica - Drug Research
dc.subjectPotentilla reptansen
dc.subjectcancer cell lineen
dc.subjectcytotoxicityen
dc.titleCytotoxic effect of Potentilla reptans L. rhizome and aerial part extractsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЦупара, Снежана; Славковска, Виолета; Томовић, Марина Т.; Јанковић, Слободан; Поповић, Сузана Л. Ј.; Радовановић, Aна М.;
dc.citation.volume70
dc.citation.issue5
dc.citation.spage851
dc.citation.epage854
dc.citation.other70(5): 851-854
dc.citation.rankM23
dc.identifier.wos000341743000008
dc.identifier.pmid24147362
dc.identifier.scopus2-s2.0-84884248858
dc.identifier.rcubconv_3155
dc.type.versionpublishedVersion


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