Development of a novel RP-HPLC method for the efficient separation of aripiprazole and its nine impurities
Само за регистроване кориснике
2013
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The development of an RP-HPLC method for the separation of aripiprazole and its nine impurities was performed with the use of partial least squares regression, response surface plot methodology, and chromatographic response function. The HPLC retention times and computed molecular parameters of the aripiprazole and its nine impurities were further used for the quantitative structure-retention relationship (QSRR) study. The QSRR model, R-2: 0.899, Q(2): 0.832, root mean square error of estimation: 4.761, root mean square error of prediction: 6.614, was developed. Very good agreement between the predicted and observed retention times (t(R)) for three additional aripiprazole impurities (TC1-TC3) indicated the high prediction potential of the QSRR model for t(R) evaluation of other aripiprazole impurities and metabolites. The developed HPLC method is the first reported method for the efficient separation of aripiprazole and its nine impurities, which could be used for the analysis of an ad...ditional three aripiprazole impurities (TC1-TC3).
Кључне речи:
Aripiprazole / Chemometry / Experimental design / HPLC / QSRRИзвор:
Journal of Separation Science, 2013, 36, 19, 3165-3175Издавач:
- Wiley-VCH Verlag GMBH, Weinheim
Финансирање / пројекти:
- Синтеза, квантитативни однос између структуре и дејства, физичко-хемијска карактеризација и анализа фармаколошки активних супстанци (RS-MESTD-Basic Research (BR or ON)-172033)
DOI: 10.1002/jssc.201300477
ISSN: 1615-9306
PubMed: 23900963
WoS: 000325139700004
Scopus: 2-s2.0-84885120125
Институција/група
PharmacyTY - JOUR AU - Nikolić, Katarina AU - Đorđević-Filijović, Nataša AU - Maricić, Borislava AU - Agbaba, Danica PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1870 AB - The development of an RP-HPLC method for the separation of aripiprazole and its nine impurities was performed with the use of partial least squares regression, response surface plot methodology, and chromatographic response function. The HPLC retention times and computed molecular parameters of the aripiprazole and its nine impurities were further used for the quantitative structure-retention relationship (QSRR) study. The QSRR model, R-2: 0.899, Q(2): 0.832, root mean square error of estimation: 4.761, root mean square error of prediction: 6.614, was developed. Very good agreement between the predicted and observed retention times (t(R)) for three additional aripiprazole impurities (TC1-TC3) indicated the high prediction potential of the QSRR model for t(R) evaluation of other aripiprazole impurities and metabolites. The developed HPLC method is the first reported method for the efficient separation of aripiprazole and its nine impurities, which could be used for the analysis of an additional three aripiprazole impurities (TC1-TC3). PB - Wiley-VCH Verlag GMBH, Weinheim T2 - Journal of Separation Science T1 - Development of a novel RP-HPLC method for the efficient separation of aripiprazole and its nine impurities VL - 36 IS - 19 SP - 3165 EP - 3175 DO - 10.1002/jssc.201300477 ER -
@article{ author = "Nikolić, Katarina and Đorđević-Filijović, Nataša and Maricić, Borislava and Agbaba, Danica", year = "2013", abstract = "The development of an RP-HPLC method for the separation of aripiprazole and its nine impurities was performed with the use of partial least squares regression, response surface plot methodology, and chromatographic response function. The HPLC retention times and computed molecular parameters of the aripiprazole and its nine impurities were further used for the quantitative structure-retention relationship (QSRR) study. The QSRR model, R-2: 0.899, Q(2): 0.832, root mean square error of estimation: 4.761, root mean square error of prediction: 6.614, was developed. Very good agreement between the predicted and observed retention times (t(R)) for three additional aripiprazole impurities (TC1-TC3) indicated the high prediction potential of the QSRR model for t(R) evaluation of other aripiprazole impurities and metabolites. The developed HPLC method is the first reported method for the efficient separation of aripiprazole and its nine impurities, which could be used for the analysis of an additional three aripiprazole impurities (TC1-TC3).", publisher = "Wiley-VCH Verlag GMBH, Weinheim", journal = "Journal of Separation Science", title = "Development of a novel RP-HPLC method for the efficient separation of aripiprazole and its nine impurities", volume = "36", number = "19", pages = "3165-3175", doi = "10.1002/jssc.201300477" }
Nikolić, K., Đorđević-Filijović, N., Maricić, B.,& Agbaba, D.. (2013). Development of a novel RP-HPLC method for the efficient separation of aripiprazole and its nine impurities. in Journal of Separation Science Wiley-VCH Verlag GMBH, Weinheim., 36(19), 3165-3175. https://doi.org/10.1002/jssc.201300477
Nikolić K, Đorđević-Filijović N, Maricić B, Agbaba D. Development of a novel RP-HPLC method for the efficient separation of aripiprazole and its nine impurities. in Journal of Separation Science. 2013;36(19):3165-3175. doi:10.1002/jssc.201300477 .
Nikolić, Katarina, Đorđević-Filijović, Nataša, Maricić, Borislava, Agbaba, Danica, "Development of a novel RP-HPLC method for the efficient separation of aripiprazole and its nine impurities" in Journal of Separation Science, 36, no. 19 (2013):3165-3175, https://doi.org/10.1002/jssc.201300477 . .