Приказ основних података о документу

dc.creatorNikolić, Katarina
dc.creatorĐorđević-Filijović, Nataša
dc.creatorMaricić, Borislava
dc.creatorAgbaba, Danica
dc.date.accessioned2019-09-02T11:33:04Z
dc.date.available2019-09-02T11:33:04Z
dc.date.issued2013
dc.identifier.issn1615-9306
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1870
dc.description.abstractThe development of an RP-HPLC method for the separation of aripiprazole and its nine impurities was performed with the use of partial least squares regression, response surface plot methodology, and chromatographic response function. The HPLC retention times and computed molecular parameters of the aripiprazole and its nine impurities were further used for the quantitative structure-retention relationship (QSRR) study. The QSRR model, R-2: 0.899, Q(2): 0.832, root mean square error of estimation: 4.761, root mean square error of prediction: 6.614, was developed. Very good agreement between the predicted and observed retention times (t(R)) for three additional aripiprazole impurities (TC1-TC3) indicated the high prediction potential of the QSRR model for t(R) evaluation of other aripiprazole impurities and metabolites. The developed HPLC method is the first reported method for the efficient separation of aripiprazole and its nine impurities, which could be used for the analysis of an additional three aripiprazole impurities (TC1-TC3).en
dc.publisherWiley-VCH Verlag GMBH, Weinheim
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Separation Science
dc.subjectAripiprazoleen
dc.subjectChemometryen
dc.subjectExperimental designen
dc.subjectHPLCen
dc.subjectQSRRen
dc.titleDevelopment of a novel RP-HPLC method for the efficient separation of aripiprazole and its nine impuritiesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМарицић, Борислава; Ђорђевић-Филијовић, Наташа; Николић, Катарина; Aгбаба, Даница;
dc.citation.volume36
dc.citation.issue19
dc.citation.spage3165
dc.citation.epage3175
dc.citation.other36(19): 3165-3175
dc.citation.rankM22
dc.identifier.wos000325139700004
dc.identifier.doi10.1002/jssc.201300477
dc.identifier.pmid23900963
dc.identifier.scopus2-s2.0-84885120125
dc.type.versionpublishedVersion


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Приказ основних података о документу