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Development of a novel RP-HPLC method for the efficient separation of aripiprazole and its nine impurities
dc.creator | Nikolić, Katarina | |
dc.creator | Đorđević-Filijović, Nataša | |
dc.creator | Maricić, Borislava | |
dc.creator | Agbaba, Danica | |
dc.date.accessioned | 2019-09-02T11:33:04Z | |
dc.date.available | 2019-09-02T11:33:04Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1615-9306 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1870 | |
dc.description.abstract | The development of an RP-HPLC method for the separation of aripiprazole and its nine impurities was performed with the use of partial least squares regression, response surface plot methodology, and chromatographic response function. The HPLC retention times and computed molecular parameters of the aripiprazole and its nine impurities were further used for the quantitative structure-retention relationship (QSRR) study. The QSRR model, R-2: 0.899, Q(2): 0.832, root mean square error of estimation: 4.761, root mean square error of prediction: 6.614, was developed. Very good agreement between the predicted and observed retention times (t(R)) for three additional aripiprazole impurities (TC1-TC3) indicated the high prediction potential of the QSRR model for t(R) evaluation of other aripiprazole impurities and metabolites. The developed HPLC method is the first reported method for the efficient separation of aripiprazole and its nine impurities, which could be used for the analysis of an additional three aripiprazole impurities (TC1-TC3). | en |
dc.publisher | Wiley-VCH Verlag GMBH, Weinheim | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Separation Science | |
dc.subject | Aripiprazole | en |
dc.subject | Chemometry | en |
dc.subject | Experimental design | en |
dc.subject | HPLC | en |
dc.subject | QSRR | en |
dc.title | Development of a novel RP-HPLC method for the efficient separation of aripiprazole and its nine impurities | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Марицић, Борислава; Ђорђевић-Филијовић, Наташа; Николић, Катарина; Aгбаба, Даница; | |
dc.citation.volume | 36 | |
dc.citation.issue | 19 | |
dc.citation.spage | 3165 | |
dc.citation.epage | 3175 | |
dc.citation.other | 36(19): 3165-3175 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000325139700004 | |
dc.identifier.doi | 10.1002/jssc.201300477 | |
dc.identifier.pmid | 23900963 | |
dc.identifier.scopus | 2-s2.0-84885120125 | |
dc.type.version | publishedVersion |