Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players
Само за регистроване кориснике
2013
Аутори
Baralić, IvanaĐorđević, Brižita
Dikić, Nenad
Kotur-Stevuljević, Jelena
Spasić, Slavica
Jelić-Ivanović, Zorana
Radivojević, Nenad
Anđelković, Marija
Pejić, Snežana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The purpose of the study was to examine the effects of astaxanthin (Asx) on paraoxonase (PON1) activities and oxidative stress status in soccer players. Forty soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. Blood samples were obtained before, 45 and 90days after supplementation. PON1 activity was assessed by using two substrates: paraoxon and diazoxon. The oxidative stress biomarkers were also examined: total sulphydryl group content (-SH groups), thiobarbituric acid-reactive substances (TBARS), advanced oxidation protein products and redox balance. The significant interaction effect of supplementation and training (p lt 0.05) on PON1 activity toward paraoxon was observed. The PON1 activity toward diazoxon increased in Asx group after 90days (p lt 0.01), while there was no significant difference in P group. SH groups content rose from pre- to post-supplementation period only in Asx group (supplementation and training, p lt 0.05; training, p... lt 0.01). TBARS levels decreased after 45days and increased after 90days of regular soccer training in both groups (training, p lt 0.001). Redox balance decreased significantly in response to the regular training, regardless of treatment group (training, p lt 0.001). Asx supplementation might increase total SH groups content and improve PON1 activity through protection of free thiol groups against oxidative modification. Copyright
Кључне речи:
astaxanthin / soccer / paraoxonase 1 activity / oxidative stressИзвор:
Phytotherapy Research, 2013, 27, 10, 1536-1542Издавач:
- Wiley-Blackwell, Hoboken
Финансирање / пројекти:
- Интерактивна улога дислипидемије, оксидативног стреса и инфламације у атеросклерози и другим болестима: генетички и биохемијски маркери (RS-MESTD-Basic Research (BR or ON)-175035)
DOI: 10.1002/ptr.4898
ISSN: 0951-418X
PubMed: 23192897
WoS: 000325365700013
Scopus: 2-s2.0-84885648766
Институција/група
PharmacyTY - JOUR AU - Baralić, Ivana AU - Đorđević, Brižita AU - Dikić, Nenad AU - Kotur-Stevuljević, Jelena AU - Spasić, Slavica AU - Jelić-Ivanović, Zorana AU - Radivojević, Nenad AU - Anđelković, Marija AU - Pejić, Snežana PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1871 AB - The purpose of the study was to examine the effects of astaxanthin (Asx) on paraoxonase (PON1) activities and oxidative stress status in soccer players. Forty soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. Blood samples were obtained before, 45 and 90days after supplementation. PON1 activity was assessed by using two substrates: paraoxon and diazoxon. The oxidative stress biomarkers were also examined: total sulphydryl group content (-SH groups), thiobarbituric acid-reactive substances (TBARS), advanced oxidation protein products and redox balance. The significant interaction effect of supplementation and training (p lt 0.05) on PON1 activity toward paraoxon was observed. The PON1 activity toward diazoxon increased in Asx group after 90days (p lt 0.01), while there was no significant difference in P group. SH groups content rose from pre- to post-supplementation period only in Asx group (supplementation and training, p lt 0.05; training, p lt 0.01). TBARS levels decreased after 45days and increased after 90days of regular soccer training in both groups (training, p lt 0.001). Redox balance decreased significantly in response to the regular training, regardless of treatment group (training, p lt 0.001). Asx supplementation might increase total SH groups content and improve PON1 activity through protection of free thiol groups against oxidative modification. Copyright PB - Wiley-Blackwell, Hoboken T2 - Phytotherapy Research T1 - Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players VL - 27 IS - 10 SP - 1536 EP - 1542 DO - 10.1002/ptr.4898 ER -
@article{ author = "Baralić, Ivana and Đorđević, Brižita and Dikić, Nenad and Kotur-Stevuljević, Jelena and Spasić, Slavica and Jelić-Ivanović, Zorana and Radivojević, Nenad and Anđelković, Marija and Pejić, Snežana", year = "2013", abstract = "The purpose of the study was to examine the effects of astaxanthin (Asx) on paraoxonase (PON1) activities and oxidative stress status in soccer players. Forty soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. Blood samples were obtained before, 45 and 90days after supplementation. PON1 activity was assessed by using two substrates: paraoxon and diazoxon. The oxidative stress biomarkers were also examined: total sulphydryl group content (-SH groups), thiobarbituric acid-reactive substances (TBARS), advanced oxidation protein products and redox balance. The significant interaction effect of supplementation and training (p lt 0.05) on PON1 activity toward paraoxon was observed. The PON1 activity toward diazoxon increased in Asx group after 90days (p lt 0.01), while there was no significant difference in P group. SH groups content rose from pre- to post-supplementation period only in Asx group (supplementation and training, p lt 0.05; training, p lt 0.01). TBARS levels decreased after 45days and increased after 90days of regular soccer training in both groups (training, p lt 0.001). Redox balance decreased significantly in response to the regular training, regardless of treatment group (training, p lt 0.001). Asx supplementation might increase total SH groups content and improve PON1 activity through protection of free thiol groups against oxidative modification. Copyright", publisher = "Wiley-Blackwell, Hoboken", journal = "Phytotherapy Research", title = "Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players", volume = "27", number = "10", pages = "1536-1542", doi = "10.1002/ptr.4898" }
Baralić, I., Đorđević, B., Dikić, N., Kotur-Stevuljević, J., Spasić, S., Jelić-Ivanović, Z., Radivojević, N., Anđelković, M.,& Pejić, S.. (2013). Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players. in Phytotherapy Research Wiley-Blackwell, Hoboken., 27(10), 1536-1542. https://doi.org/10.1002/ptr.4898
Baralić I, Đorđević B, Dikić N, Kotur-Stevuljević J, Spasić S, Jelić-Ivanović Z, Radivojević N, Anđelković M, Pejić S. Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players. in Phytotherapy Research. 2013;27(10):1536-1542. doi:10.1002/ptr.4898 .
Baralić, Ivana, Đorđević, Brižita, Dikić, Nenad, Kotur-Stevuljević, Jelena, Spasić, Slavica, Jelić-Ivanović, Zorana, Radivojević, Nenad, Anđelković, Marija, Pejić, Snežana, "Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players" in Phytotherapy Research, 27, no. 10 (2013):1536-1542, https://doi.org/10.1002/ptr.4898 . .