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Experimental Design in Formulation of Diazepam Nanoemulsions: Physicochemical and Pharmacokinetic Performances
dc.creator | Đorđević, Sanela | |
dc.creator | Radulović, Tamara | |
dc.creator | Cekić, Nebojša | |
dc.creator | Ranđelović, Danijela | |
dc.creator | Savić, Miroslav | |
dc.creator | Krajišnik, Danina | |
dc.creator | Milić, Jela | |
dc.creator | Savić, Snežana | |
dc.date.accessioned | 2019-09-02T11:33:10Z | |
dc.date.available | 2019-09-02T11:33:10Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0022-3549 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1873 | |
dc.description.abstract | With the aid of experimental design, we developed and characterized nanoemulsions for parenteral drug delivery. Formulations containing a mixture of medium-chain triglycerides and soybean oil as oil phase, lecithin (soybean/egg) and polysorbate 80 as emulsifiers, and 0.1M phosphate buffer solution (pH 8) as aqueous phase were prepared by cold high-pressure homogenization. To study the effects of the oil content, lecithin type, and the presence of diazepam as a model drug and their interactions on physicochemical characteristics of nanoemulsions, a three factor two-level full factorial design was applied. The nanoemulsions were evaluated concerning droplet size and size distribution, surface charge, viscosity, morphology, drug-excipient interactions, and physical stability. The characterization revealed the small spherical droplets in the range 195-220nm with polydispersity index below 0.15 and zeta potential between -30 and -60mV. Interactions among the investigated factors, rather than factors alone, were shown to more profoundly affect nanoemulsion characteristics. In vivo pharmacokinetic study of selected diazepam nanoemulsions with different oil content (20%, 30%, and 40%, w/w) demonstrated fast and intense initial distribution into rat brain of diazepam from nanoemulsions with 20% and 30% (w/w) oil content, suggesting their applicability in urgent situations. | en |
dc.publisher | Wiley-Blackwell, Hoboken | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Pharmaceutical Sciences | |
dc.subject | nanoemulsion | en |
dc.subject | diazepam | en |
dc.subject | full factorial design | en |
dc.subject | particle size | en |
dc.subject | atomic force microscopy | en |
dc.subject | FTIR | en |
dc.subject | drug-excipient interaction | en |
dc.subject | stability | en |
dc.subject | pharmacokinetics | en |
dc.title | Experimental Design in Formulation of Diazepam Nanoemulsions: Physicochemical and Pharmacokinetic Performances | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Ранђеловић, Данијела; Крајишник, Данина; Цекић, Небојша; Радуловић, Тамара; Савић, Мирослав; Милић, Јела; Савић, Снежана; Ђорђевић, Санела; | |
dc.citation.volume | 102 | |
dc.citation.issue | 11 | |
dc.citation.spage | 4159 | |
dc.citation.epage | 4172 | |
dc.citation.other | 102(11): 4159-4172 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000325550400032 | |
dc.identifier.doi | 10.1002/jps.23734 | |
dc.identifier.pmid | 24114833 | |
dc.identifier.scopus | 2-s2.0-84885846550 | |
dc.type.version | publishedVersion |