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Water-Dilutable Biocompatible Microemulsion Systems: Design and Characterisation

Authorized Users Only
2013
Authors
Đekić, Ljiljana
Cirković, Violeta
Heleta, Mirjana
Krajišnik, Danina
Primorac, Marija
Article (Published version)
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Abstract
The present study describes a screening approach in design of microemulsion preconcentrates (self-microemulsifying systems) comprising: PEG-8 caprylic/capric glycerides (Labrasol (R)) (surfactant), PEG-40 hydrogenated castor oil (Cremophor (R) RH40) (cosurfactant) (at surfactant-to-cosurfactant mass ratios 9:1, 7:3, 5:5, 3:7 and 1:9), and 10% w/w or 20% w/w of medium-chain triglycerides or olive oil (oil). The self-microemulsifying ability of the prepared surfactant/cosurfactant/oil mixtures in water and 0.1 M HCl (pH 1.2), was evaluated by droplet size and zeta potential analysis and cross-polarized light microscopy. The formation of microemulsions was observed only in the presence of medium-chain triglycerides at surfactant-to-cosurfactant ratios 7:3 and 5:5 (in the mixtures containing 10% w/w of the oil phase) and 3:7 and 1:9 (when 20% w/w of the same oil was used). The obtained results provide new implications for development of microemulsion preconcentrates suitable as delivery sy...stems for food and pharmaceutical applications.

Keywords:
Microemulsions / self-microemulsifying systems / Labrasol (R) / Cremophor (R) RH40
Source:
Tetrahedron, 2013, 50, 6, 409-413
Publisher:
  • Carl Hanser Verlag, Munich
Projects:
  • Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness (RS-46010)

DOI: 10.3139/113.110272

ISSN: 0932-3414

WoS: 000329008700001

Scopus: 2-s2.0-84889784075
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1878
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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