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Water-Dilutable Biocompatible Microemulsion Systems: Design and Characterisation
dc.creator | Đekić, Ljiljana | |
dc.creator | Cirković, Violeta | |
dc.creator | Heleta, Mirjana | |
dc.creator | Krajišnik, Danina | |
dc.creator | Primorac, Marija | |
dc.date.accessioned | 2019-09-02T11:33:18Z | |
dc.date.available | 2019-09-02T11:33:18Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0932-3414 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1878 | |
dc.description.abstract | The present study describes a screening approach in design of microemulsion preconcentrates (self-microemulsifying systems) comprising: PEG-8 caprylic/capric glycerides (Labrasol (R)) (surfactant), PEG-40 hydrogenated castor oil (Cremophor (R) RH40) (cosurfactant) (at surfactant-to-cosurfactant mass ratios 9:1, 7:3, 5:5, 3:7 and 1:9), and 10% w/w or 20% w/w of medium-chain triglycerides or olive oil (oil). The self-microemulsifying ability of the prepared surfactant/cosurfactant/oil mixtures in water and 0.1 M HCl (pH 1.2), was evaluated by droplet size and zeta potential analysis and cross-polarized light microscopy. The formation of microemulsions was observed only in the presence of medium-chain triglycerides at surfactant-to-cosurfactant ratios 7:3 and 5:5 (in the mixtures containing 10% w/w of the oil phase) and 3:7 and 1:9 (when 20% w/w of the same oil was used). The obtained results provide new implications for development of microemulsion preconcentrates suitable as delivery systems for food and pharmaceutical applications. | en |
dc.publisher | Carl Hanser Verlag, Munich | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS// | |
dc.rights | restrictedAccess | |
dc.source | Tenside Surfactants Detergents | |
dc.subject | Microemulsions | en |
dc.subject | self-microemulsifying systems | en |
dc.subject | Labrasol (R) | en |
dc.subject | Cremophor (R) RH40 | en |
dc.title | Water-Dilutable Biocompatible Microemulsion Systems: Design and Characterisation | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Ђекић, Љиљана; Хелета, Мирјана; Приморац, Марија; Крајишник, Данина; Цирковић, Виолета; | |
dc.citation.volume | 50 | |
dc.citation.issue | 6 | |
dc.citation.spage | 409 | |
dc.citation.epage | 413 | |
dc.citation.other | 50(6): 409-413 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000329008700001 | |
dc.identifier.doi | 10.3139/113.110272 | |
dc.identifier.scopus | 2-s2.0-84889784075 | |
dc.type.version | publishedVersion |