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dc.creatorDaković, Marko
dc.creatorStojiljković, Aleksandra S.
dc.creatorBajuk-Bogdanović, Danica
dc.creatorStarcević, Ana
dc.creatorPuskas, Laslo
dc.creatorFilipović, Branislav
dc.creatorUskoković-Marković, Snežana
dc.creatorHolclajtner-Antunović, Ivanka
dc.date.accessioned2019-09-02T11:33:26Z
dc.date.available2019-09-02T11:33:26Z
dc.date.issued2013
dc.identifier.issn0039-9140
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1883
dc.description.abstractRaman spectroscopy enables non-invasive investigation of chemical composition of biological tissues. Due to similar chemical composition, the analysis of Raman spectra of brain structures and assignment of their spectral features to chemical constituents presents a particular challenge. In this study we demonstrate that standard and independent component analysis of Raman spectra is capable of assessment of differences in chemical composition between functionally related gray and white matter structures. Our results show the ability of Raman spectroscopy to successfully depict variation in chemical composition between structurally similar and/or functionally connected brain structures. The observed differences were attributed to variations in content of proteins and lipids in these structures. Independent component analysis enabled separation of contributions of major constituents in spectra and revealed spectral signatures of low-concentration metabolites. This provided finding of discrepancies between structures of striatum as well as between white matter structures. Raman spectroscopy can provide information about variations in contents of major chemical constituents in brain structures, while the application of independent component analysis performed on obtained spectra can help in revealing minute differences between closely related brain structures.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41005/RS//
dc.rightsrestrictedAccess
dc.sourceTalanta
dc.subjectRaman spectroscopyen
dc.subjectBrain tissueen
dc.subjectChemical compositionen
dc.subjectIndependent component analysisen
dc.titleProfiling differences in chemical composition of brain structures using Raman spectroscopyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтојиљковић, Aлександра С.; Старцевић, Aна; Ускоковић-Марковић, Снежана; Бајук-Богдановић, Даница; Холцлајтнер-Aнтуновић, Иванка; Даковић, Марко; Филиповић, Бранислав; Пускас, Ласло;
dc.citation.volume117
dc.citation.spage133
dc.citation.epage138
dc.citation.other117: 133-138
dc.citation.rankM21
dc.identifier.wos000328801400021
dc.identifier.doi10.1016/j.talanta.2013.08.058
dc.identifier.pmid24209321
dc.identifier.scopus2-s2.0-84884676652
dc.identifier.rcubconv_2986
dc.type.versionpublishedVersion


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