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dc.creatorPavlović, Dragana R.
dc.creatorTasić-Kostov, Marija
dc.creatorMarčetić, Mirjana
dc.creatorLakušić, Branislava
dc.creatorKitić, Dušanka
dc.creatorSavić, Snežana
dc.creatorKovačević, Nada
dc.date.accessioned2019-09-02T11:33:27Z
dc.date.available2019-09-02T11:33:27Z
dc.date.issued2013
dc.identifier.issn0035-6808
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1885
dc.description.abstractArbutus unedo, Bruckentalia spiculifolia, Calluna vulgaris, Erica arborea and Erica carnea possess strong antioxidant activity and they are traditionally used for the treatment of various skin diseases. The present study investigated the total phenylpropanoid content, antioxidant properties and phenolic composition of dry leaf ethanol extracts of these species. Furthermore, the in vivo effects of gels, each containing 2% of a single extract were tested on the artificially irritated human skin using the objective methods of skin biophysical measurements (erythema index (EI), pH of the skin and electrical capacitance (EC) as a measure of skin hydration level were assessed). In total, 13 components were identified by RP-HPLC coupled with DAD detection; quercitrin, quercetin 3-O-glucoside and gallic acid were detected in all investigated samples while chlorogenic acid and quercetin were present in 4 samples. Regarding the in vivo study, all investigated gels significantly decreased the skin irritation level and reversed the pH of the skin disturbed by preirritation, while results were contradictory regarding skin hydration measurements. In conclusion, the assessed in vivo topical effects of investigated extracts matched well with their phenylpropanoid content as well as with assessed antioxidant activities.en
dc.publisherInnovhub Ssi-Area Ssog, Milano
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41018/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173021/RS//
dc.rightsopenAccess
dc.sourceRSC Advances
dc.subjectEricaceaeen
dc.subjectskin biophysical measurementsen
dc.subjectirritated human skinen
dc.subjectantioxidanten
dc.subjectphenylpropanoiden
dc.subjectRP-HPLCen
dc.titleEvaluation of in vivo effects on surfactant-irritated human skin, antioxidant properties and phenolic composition of five Ericaceae species extractsen
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractМарчетић, Мирјана; Павловић, Драгана Р.; Савић, Снежана; Китић, Душанка; Лакушић, Бранислава; Тасић-Костов, Марија; Ковачевић, Нада;
dc.citation.volume90
dc.citation.issue4
dc.citation.spage255
dc.citation.epage264
dc.citation.other90(4): 255-264
dc.citation.rankM23
dc.identifier.wos000328722100006
dc.identifier.scopus2-s2.0-84893267830
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/7337/Evaluation_vivo_effects_pub_2013.pdf
dc.identifier.rcubconv_2985
dc.type.versionpublishedVersion


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