Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization
2013
Аутори
Mandić, Boris M.Simić, Milena
Vucković, Ivan M.
Vujisić, Ljubodrag V.
Novaković, Miroslav
Trifunović, Snežana
Nikolić-Mandić, Snežana D.
Tešević, Vele
Vajs, Vlatka
Milosavljević, Slobodan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.
Кључне речи:
Rindera umbellata / pyrrolizidine alkaloids / fatty acids / tubulin polymerizationИзвор:
Molecules, 2013, 18, 9, 10694-10706Издавач:
- MDPI, Basel
Финансирање / пројекти:
- Биоактивни природни производи самониклих, гајених и јестивих биљака: одређивање структура и активности (RS-MESTD-Basic Research (BR or ON)-172053)
DOI: 10.3390/molecules180910694
ISSN: 1420-3049
PubMed: 24005964
WoS: 000330306600041
Scopus: 2-s2.0-84885140370
Институција/група
PharmacyTY - JOUR AU - Mandić, Boris M. AU - Simić, Milena AU - Vucković, Ivan M. AU - Vujisić, Ljubodrag V. AU - Novaković, Miroslav AU - Trifunović, Snežana AU - Nikolić-Mandić, Snežana D. AU - Tešević, Vele AU - Vajs, Vlatka AU - Milosavljević, Slobodan PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1894 AB - The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined. PB - MDPI, Basel T2 - Molecules T1 - Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization VL - 18 IS - 9 SP - 10694 EP - 10706 DO - 10.3390/molecules180910694 ER -
@article{ author = "Mandić, Boris M. and Simić, Milena and Vucković, Ivan M. and Vujisić, Ljubodrag V. and Novaković, Miroslav and Trifunović, Snežana and Nikolić-Mandić, Snežana D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan", year = "2013", abstract = "The examination of the aerial parts, roots, and seeds of the endemic plant Rindera umbellata is reported in this paper for the first time. Phytochemical investigation of R. umbellata led to the isolation and characterization of ten pyrrolizidine alkaloids and eleven fatty acids in the form of triglycerides. Pyrrolizidine alkaloids 1-9 were found in the aerial parts, 7 and 8 in the roots, and 6-10, together with eleven fatty acids, in the seeds of this plant species. The structures of compounds 1-10 were established based on spectroscopic studies (H-1- and C-13-NMR, 2D NMR, IR and CI-MS). After trans-esterification, methyl esters of the fatty acids were analyzed using GC-MS. The effect of lindelofine-N-oxide (7) on tubulin polymerization was determined.", publisher = "MDPI, Basel", journal = "Molecules", title = "Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization", volume = "18", number = "9", pages = "10694-10706", doi = "10.3390/molecules180910694" }
Mandić, B. M., Simić, M., Vucković, I. M., Vujisić, L. V., Novaković, M., Trifunović, S., Nikolić-Mandić, S. D., Tešević, V., Vajs, V.,& Milosavljević, S.. (2013). Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization. in Molecules MDPI, Basel., 18(9), 10694-10706. https://doi.org/10.3390/molecules180910694
Mandić BM, Simić M, Vucković IM, Vujisić LV, Novaković M, Trifunović S, Nikolić-Mandić SD, Tešević V, Vajs V, Milosavljević S. Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization. in Molecules. 2013;18(9):10694-10706. doi:10.3390/molecules180910694 .
Mandić, Boris M., Simić, Milena, Vucković, Ivan M., Vujisić, Ljubodrag V., Novaković, Miroslav, Trifunović, Snežana, Nikolić-Mandić, Snežana D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan, "Pyrrolizidine Alkaloids and Fatty Acids from the Endemic Plant Species Rindera umbellata and the Effect of Lindelofine-N-oxide on Tubulin Polymerization" in Molecules, 18, no. 9 (2013):10694-10706, https://doi.org/10.3390/molecules180910694 . .