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Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?

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2013
Authors
Memon, Lidija
Spasojević-Kalimanovska, Vesna
Bogavac-Stanojević, Nataša
Kotur-Stevuljević, Jelena
Simić-Ogrizović, Sanja
Giga, Vojislav
Dopsaj, Violeta
Jelić-Ivanović, Zorana
Spasić, Slavica
Article (Published version)
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Abstract
BackgroundThe aim of the study was to determine the clinical usefulness of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and symmetric dimethylarginine (SDMA) for detection of renal and left ventricular (LV) diastolic dysfunction in chronic kidney disease (CKD) patients and renal transplant (RT) recipients. MethodsWe included 98 CKD and 44 RT patients. We assessed LV function using pulsed-wave Doppler ultrasound. Diastolic dysfunction was defined when the E:A ratio was lt 1. ResultsIndependent predictors of NT-proBNP levels were age, creatinine, and albumin in CKD patients and age and urea in RT patients. Determinants of SDMA in CKD patients were glomerular filtration rate (GFR) and NT-proBNP and creatinine in RT patients. In RT patients with diastolic dysfunction, NT-proBNP and SDMA were significantly higher than in patients without diastolic dysfunction (F = 7.478, P lt 0.011; F = 2.631, P lt 0.017). After adjustment for GFR, the differences were not seen. In CKD patient...s adjusted NT-proBNP and SDMA values for GFR were not significantly higher in patients with diastolic dysfunction than in patients without diastolic dysfunction. ConclusionsNT-proBNP is useful for detection of LV diastolic dysfunction in RT recipients. When evaluating both NT-proBNP and SDMA it is necessary to consider GFR as a confounding factor.

Keywords:
chronic kidney disease / renal transplant recipients / N-terminal pro B-type natriuretic peptide / symmetric dimethylarginine / diastolic dysfunction
Source:
Journal of Clinical Laboratory Analysis, 2013, 27, 6, 461-470
Publisher:
  • Wiley, Hoboken
Projects:
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)

DOI: 10.1002/jcla.21628

ISSN: 0887-8013

PubMed: 24218128

WoS: 000326890600007

Scopus: 2-s2.0-84887357761
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1897
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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