Investigation of adsorption and release of diclofenac sodium by modified zeolites composites
Authorized Users Only
2013
Authors
Krajišnik, Danina
Daković, Aleksandra
Malenović, Anđelija

Milojević-Rakić, Maja

Dondur, Vera

Radulović, Željka
Milić, Jela
Article (Published version)

Metadata
Show full item recordAbstract
Results on adsorption of diclofenac sodium (DS) by modified natural zeolite composites at three levels (10,20 and 30 mmol/100 g) of cationic surfactant-hexadecyltrimethylammonium bromide (HB), in a buffer solution, were compared. Characterization of composites before and after drug adsorption was performed by determination of electrokinetic mobility, FTIR and thermal analysis. The results indicated interactions between drug and carriers. The pharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments. The results were compared with the drug release from corresponding physical mixtures. Prolonged drug release over a period of 8 h (up to 30%) was achieved with both groups of samples. Furthermore, DS release reached up to 85% from physical mixtures containing drug amount closer to a therapeutic dose.
Keywords:
Clinoptilolite / Cationic surfactant / Adsorption / Excipient / Diclofenac sodium / DissolutionSource:
Applied Clay Science, 2013, 322-326Publisher:
- Elsevier Science BV, Amsterdam
Funding / projects:
DOI: 10.1016/j.clay.2013.08.011
ISSN: 0169-1317
WoS: 000326661300043
Scopus: 2-s2.0-84885078956
Collections
Institution/Community
PharmacyTY - JOUR AU - Krajišnik, Danina AU - Daković, Aleksandra AU - Malenović, Anđelija AU - Milojević-Rakić, Maja AU - Dondur, Vera AU - Radulović, Željka AU - Milić, Jela PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1905 AB - Results on adsorption of diclofenac sodium (DS) by modified natural zeolite composites at three levels (10,20 and 30 mmol/100 g) of cationic surfactant-hexadecyltrimethylammonium bromide (HB), in a buffer solution, were compared. Characterization of composites before and after drug adsorption was performed by determination of electrokinetic mobility, FTIR and thermal analysis. The results indicated interactions between drug and carriers. The pharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments. The results were compared with the drug release from corresponding physical mixtures. Prolonged drug release over a period of 8 h (up to 30%) was achieved with both groups of samples. Furthermore, DS release reached up to 85% from physical mixtures containing drug amount closer to a therapeutic dose. PB - Elsevier Science BV, Amsterdam T2 - Applied Clay Science T1 - Investigation of adsorption and release of diclofenac sodium by modified zeolites composites SP - 322 EP - 326 DO - 10.1016/j.clay.2013.08.011 ER -
@article{ author = "Krajišnik, Danina and Daković, Aleksandra and Malenović, Anđelija and Milojević-Rakić, Maja and Dondur, Vera and Radulović, Željka and Milić, Jela", year = "2013", abstract = "Results on adsorption of diclofenac sodium (DS) by modified natural zeolite composites at three levels (10,20 and 30 mmol/100 g) of cationic surfactant-hexadecyltrimethylammonium bromide (HB), in a buffer solution, were compared. Characterization of composites before and after drug adsorption was performed by determination of electrokinetic mobility, FTIR and thermal analysis. The results indicated interactions between drug and carriers. The pharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments. The results were compared with the drug release from corresponding physical mixtures. Prolonged drug release over a period of 8 h (up to 30%) was achieved with both groups of samples. Furthermore, DS release reached up to 85% from physical mixtures containing drug amount closer to a therapeutic dose.", publisher = "Elsevier Science BV, Amsterdam", journal = "Applied Clay Science", title = "Investigation of adsorption and release of diclofenac sodium by modified zeolites composites", pages = "322-326", doi = "10.1016/j.clay.2013.08.011" }
Krajišnik, D., Daković, A., Malenović, A., Milojević-Rakić, M., Dondur, V., Radulović, Ž.,& Milić, J.. (2013). Investigation of adsorption and release of diclofenac sodium by modified zeolites composites. in Applied Clay Science Elsevier Science BV, Amsterdam., 322-326. https://doi.org/10.1016/j.clay.2013.08.011
Krajišnik D, Daković A, Malenović A, Milojević-Rakić M, Dondur V, Radulović Ž, Milić J. Investigation of adsorption and release of diclofenac sodium by modified zeolites composites. in Applied Clay Science. 2013;:322-326. doi:10.1016/j.clay.2013.08.011 .
Krajišnik, Danina, Daković, Aleksandra, Malenović, Anđelija, Milojević-Rakić, Maja, Dondur, Vera, Radulović, Željka, Milić, Jela, "Investigation of adsorption and release of diclofenac sodium by modified zeolites composites" in Applied Clay Science (2013):322-326, https://doi.org/10.1016/j.clay.2013.08.011 . .