Preparation, characterisation and study of in vitro biologically active azamacrocyclic Cu(II) dicarboxylate complexes
Authorized Users Only
2013
Authors
Antonijević-Nikolić, Mirjana
Antić-Stanković, Jelena

Tanasković, Slađana

Korabik, Maria J.

Gojgić-Cvijović, Gordana

Vucković, Gordana
Article (Published version)

Metadata
Show full item recordAbstract
New cationic Cu(II) complexes with N, N', N '', N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc) and aliphatic dicarboxylic acids: pentanedioic (glutaric acid = glutH(2)), hexanedioic acid (adipic acid = adipH(2)) and decanedioic acid (sebacic acid = sebH(2)) of general formula [Cu-4(L)(tpmc)(2)] (ClO4)(6)center dot xH(2)O, L = glut, x = 2; L = adip, x = 7; L = seb, x = 6 were isolated. Their composition and charges are proposed based on elemental analyses and molar conductivity measurements. By the comparison of their UV-Vis, reflectance, FTIR and EPR spectral data, CV and SQUID magnetic measurements, with those for the complex with butanedioic acid (succinic acid = succH(2)) of known molecular structure and analysis of LC/MS spectra, geometry with two [Cu(2)tpmc](4) units bridged by dicarboxylate dianion engaging all oxygens is proposed. Within units, Cu(II) ions are also bridged with -N- portion of cyclam ring. All four complexes were screened to in vitro anti...microbial and cytotoxic activity along with free primary and secondary ligands, Cu(II) salt and solvent controls. Detected antibacterial and cytotoxic activity for the complexes was enhanced in most cases than the corresponding controls.
Keywords:
Copper(II) complexes / Octaazamacrocycle / Aliphatic dicarboxylates / Antibacterial and cytotoxic activity / Magnetic propertiesSource:
Journal of Molecular Structure, 2013, 1054, 297-306Publisher:
- Elsevier Science BV, Amsterdam
Funding / projects:
DOI: 10.1016/j.molstruc.2013.10.006
ISSN: 0022-2860
WoS: 000327921100039
Scopus: 2-s2.0-84886104454
Collections
Institution/Community
PharmacyTY - JOUR AU - Antonijević-Nikolić, Mirjana AU - Antić-Stanković, Jelena AU - Tanasković, Slađana AU - Korabik, Maria J. AU - Gojgić-Cvijović, Gordana AU - Vucković, Gordana PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1907 AB - New cationic Cu(II) complexes with N, N', N '', N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc) and aliphatic dicarboxylic acids: pentanedioic (glutaric acid = glutH(2)), hexanedioic acid (adipic acid = adipH(2)) and decanedioic acid (sebacic acid = sebH(2)) of general formula [Cu-4(L)(tpmc)(2)] (ClO4)(6)center dot xH(2)O, L = glut, x = 2; L = adip, x = 7; L = seb, x = 6 were isolated. Their composition and charges are proposed based on elemental analyses and molar conductivity measurements. By the comparison of their UV-Vis, reflectance, FTIR and EPR spectral data, CV and SQUID magnetic measurements, with those for the complex with butanedioic acid (succinic acid = succH(2)) of known molecular structure and analysis of LC/MS spectra, geometry with two [Cu(2)tpmc](4) units bridged by dicarboxylate dianion engaging all oxygens is proposed. Within units, Cu(II) ions are also bridged with -N- portion of cyclam ring. All four complexes were screened to in vitro antimicrobial and cytotoxic activity along with free primary and secondary ligands, Cu(II) salt and solvent controls. Detected antibacterial and cytotoxic activity for the complexes was enhanced in most cases than the corresponding controls. PB - Elsevier Science BV, Amsterdam T2 - Journal of Molecular Structure T1 - Preparation, characterisation and study of in vitro biologically active azamacrocyclic Cu(II) dicarboxylate complexes VL - 1054 SP - 297 EP - 306 DO - 10.1016/j.molstruc.2013.10.006 ER -
@article{ author = "Antonijević-Nikolić, Mirjana and Antić-Stanković, Jelena and Tanasković, Slađana and Korabik, Maria J. and Gojgić-Cvijović, Gordana and Vucković, Gordana", year = "2013", abstract = "New cationic Cu(II) complexes with N, N', N '', N'''-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc) and aliphatic dicarboxylic acids: pentanedioic (glutaric acid = glutH(2)), hexanedioic acid (adipic acid = adipH(2)) and decanedioic acid (sebacic acid = sebH(2)) of general formula [Cu-4(L)(tpmc)(2)] (ClO4)(6)center dot xH(2)O, L = glut, x = 2; L = adip, x = 7; L = seb, x = 6 were isolated. Their composition and charges are proposed based on elemental analyses and molar conductivity measurements. By the comparison of their UV-Vis, reflectance, FTIR and EPR spectral data, CV and SQUID magnetic measurements, with those for the complex with butanedioic acid (succinic acid = succH(2)) of known molecular structure and analysis of LC/MS spectra, geometry with two [Cu(2)tpmc](4) units bridged by dicarboxylate dianion engaging all oxygens is proposed. Within units, Cu(II) ions are also bridged with -N- portion of cyclam ring. All four complexes were screened to in vitro antimicrobial and cytotoxic activity along with free primary and secondary ligands, Cu(II) salt and solvent controls. Detected antibacterial and cytotoxic activity for the complexes was enhanced in most cases than the corresponding controls.", publisher = "Elsevier Science BV, Amsterdam", journal = "Journal of Molecular Structure", title = "Preparation, characterisation and study of in vitro biologically active azamacrocyclic Cu(II) dicarboxylate complexes", volume = "1054", pages = "297-306", doi = "10.1016/j.molstruc.2013.10.006" }
Antonijević-Nikolić, M., Antić-Stanković, J., Tanasković, S., Korabik, M. J., Gojgić-Cvijović, G.,& Vucković, G.. (2013). Preparation, characterisation and study of in vitro biologically active azamacrocyclic Cu(II) dicarboxylate complexes. in Journal of Molecular Structure Elsevier Science BV, Amsterdam., 1054, 297-306. https://doi.org/10.1016/j.molstruc.2013.10.006
Antonijević-Nikolić M, Antić-Stanković J, Tanasković S, Korabik MJ, Gojgić-Cvijović G, Vucković G. Preparation, characterisation and study of in vitro biologically active azamacrocyclic Cu(II) dicarboxylate complexes. in Journal of Molecular Structure. 2013;1054:297-306. doi:10.1016/j.molstruc.2013.10.006 .
Antonijević-Nikolić, Mirjana, Antić-Stanković, Jelena, Tanasković, Slađana, Korabik, Maria J., Gojgić-Cvijović, Gordana, Vucković, Gordana, "Preparation, characterisation and study of in vitro biologically active azamacrocyclic Cu(II) dicarboxylate complexes" in Journal of Molecular Structure, 1054 (2013):297-306, https://doi.org/10.1016/j.molstruc.2013.10.006 . .