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Radioprotectors - the Evergreen Topic

Authorized Users Only
2013
Authors
Kuntić, Vesna
Stanković, Miroslava
Vujić, Zorica
Brborić, Jasmina
Uskoković-Marković, Snežana
Article (Published version)
Metadata
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Abstract
To protect organisms from ionizing radiation (IR), and to reduce morbidity or mortality, various agents, called radioprotectors, have been utilized. Because radiation-induced cellular damage is attributed primarily to the harmful effects of free radicals, molecules with radical-scavenging properties are particularly promising as radioprotectors. Early development of such agents focused on thiol synthetic compounds, known as WR protectors, but only amifostine (WR-2721) has been used in clinical trials as an officially approved radioprotector. Besides thiol compounds, various compounds with different chemical structure were investigated, but an ideal radioprotector has not been found yet. Plants and natural products have been evaluated as promising sources of radioprotectors because of their low toxicity, although they exhibit an inferior protection level compared to synthetic thiol compounds. Active plant constituents seem to exert the radioprotection through antioxidant and free radica...l-scavenging activities. Our research established that plants containing polyphenolic compounds (raspberry, blueberry, strawberry, grape, etc.) exhibit antioxidative activities and protect genetic material from IR.

Keywords:
Radioprotectors / Ionizing radiation / Antioxidant activity / Radical-scavenging activity / Polyphenols
Source:
Chemistry & Biodiversity, 2013, 10, 10, 1791-1803
Publisher:
  • Wiley-VCH Verlag GMBH, Weinheim
Projects:
  • Development of molecules with antiinflammatory and cardioprotective activity: structural modifications, modelling, physicochemical characterization and formulation investigations (RS-172041)

DOI: 10.1002/cbdv.201300054

ISSN: 1612-1872

PubMed: 24130023

WoS: 000328134400004

Scopus: 2-s2.0-84886001080
[ Google Scholar ]
32
28
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1910
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy
TY  - JOUR
AU  - Kuntić, Vesna
AU  - Stanković, Miroslava
AU  - Vujić, Zorica
AU  - Brborić, Jasmina
AU  - Uskoković-Marković, Snežana
PY  - 2013
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1910
AB  - To protect organisms from ionizing radiation (IR), and to reduce morbidity or mortality, various agents, called radioprotectors, have been utilized. Because radiation-induced cellular damage is attributed primarily to the harmful effects of free radicals, molecules with radical-scavenging properties are particularly promising as radioprotectors. Early development of such agents focused on thiol synthetic compounds, known as WR protectors, but only amifostine (WR-2721) has been used in clinical trials as an officially approved radioprotector. Besides thiol compounds, various compounds with different chemical structure were investigated, but an ideal radioprotector has not been found yet. Plants and natural products have been evaluated as promising sources of radioprotectors because of their low toxicity, although they exhibit an inferior protection level compared to synthetic thiol compounds. Active plant constituents seem to exert the radioprotection through antioxidant and free radical-scavenging activities. Our research established that plants containing polyphenolic compounds (raspberry, blueberry, strawberry, grape, etc.) exhibit antioxidative activities and protect genetic material from IR.
PB  - Wiley-VCH Verlag GMBH, Weinheim
T2  - Chemistry & Biodiversity
T1  - Radioprotectors - the Evergreen Topic
VL  - 10
IS  - 10
SP  - 1791
EP  - 1803
DO  - 10.1002/cbdv.201300054
ER  - 
@article{
author = "Kuntić, Vesna and Stanković, Miroslava and Vujić, Zorica and Brborić, Jasmina and Uskoković-Marković, Snežana",
year = "2013",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/1910",
abstract = "To protect organisms from ionizing radiation (IR), and to reduce morbidity or mortality, various agents, called radioprotectors, have been utilized. Because radiation-induced cellular damage is attributed primarily to the harmful effects of free radicals, molecules with radical-scavenging properties are particularly promising as radioprotectors. Early development of such agents focused on thiol synthetic compounds, known as WR protectors, but only amifostine (WR-2721) has been used in clinical trials as an officially approved radioprotector. Besides thiol compounds, various compounds with different chemical structure were investigated, but an ideal radioprotector has not been found yet. Plants and natural products have been evaluated as promising sources of radioprotectors because of their low toxicity, although they exhibit an inferior protection level compared to synthetic thiol compounds. Active plant constituents seem to exert the radioprotection through antioxidant and free radical-scavenging activities. Our research established that plants containing polyphenolic compounds (raspberry, blueberry, strawberry, grape, etc.) exhibit antioxidative activities and protect genetic material from IR.",
publisher = "Wiley-VCH Verlag GMBH, Weinheim",
journal = "Chemistry & Biodiversity",
title = "Radioprotectors - the Evergreen Topic",
volume = "10",
number = "10",
pages = "1791-1803",
doi = "10.1002/cbdv.201300054"
}
Kuntić V, Stanković M, Vujić Z, Brborić J, Uskoković-Marković S. Radioprotectors - the Evergreen Topic. Chemistry & Biodiversity. 2013;10(10):1791-1803
Kuntić, V., Stanković, M., Vujić, Z., Brborić, J.,& Uskoković-Marković, S. (2013). Radioprotectors - the Evergreen Topic.
Chemistry & BiodiversityWiley-VCH Verlag GMBH, Weinheim., 10(10), 1791-1803.
https://doi.org/10.1002/cbdv.201300054
Kuntić Vesna, Stanković Miroslava, Vujić Zorica, Brborić Jasmina, Uskoković-Marković Snežana, "Radioprotectors - the Evergreen Topic" 10, no. 10 (2013):1791-1803,
https://doi.org/10.1002/cbdv.201300054 .

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