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Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis

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2013
1910.pdf (311.6Kb)
Authors
Vekić, Jelena
Zeljković, Aleksandra
Jelić-Ivanović, Zorana
Spasojević-Kalimanovska, Vesna
Spasić, Slavica
Videnović-Ivanov, Jelica
Ivanišević, Jasmina
Vučinić-Mihailović, Violeta
Gojković, Tamara
Article (Published version)
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Abstract
Context.-Systemic inflammatory diseases are associated with proatherogenic lipoprotein profile, but there is a lack of information regarding overall distributions of lipoprotein subclasses in sarcoidosis. Objective.-To investigate whether patients with sarcoidosis have altered distributions of plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Design.-Seventy-seven patients with biopsy-proven sarcoidosis (29 with acute and 48 with chronic sarcoidosis) treated with corticosteroids and 77 age-and sex-matched controls were included in the study. Low-density lipoprotein and HDL subclasses were determined by gradient gel electrophoresis, while inflammatory markers and lipid parameters were measured by standard laboratory methods. Results.-Compared to controls, patients had fewer LDL I subclasses (P lt .001), but more LDL II and III (P lt .001) subclasses. This pattern was evident in both acute and chronic disease groups. Patients also had smaller HDL size... (P lt .001) and higher proportions of HDL 2a (P = .006) and 3a particles (P = .004). Patients with chronic sarcoidosis had smaller LDL size than those with acute disease (P = .02) and higher proportions of HDL 3a subclasses (P = .04) than controls. In acute sarcoidosis, relative proportions of LDL and HDL particles were associated with levels of inflammatory markers, whereas in chronic disease an association with concentrations of serum lipid parameters was found. Conclusions.-The obtained results demonstrate adverse lipoprotein subfraction profile in sarcoidosis with sustained alterations during disease course. Evaluation of LDL and HDL particles may be helpful in identifying patients with higher cardiovascular risk, at least for prolonged corticosteroid therapy due to chronic disease course.

Source:
Archives of Pathology & Laboratory Medicine, 2013, 137, 12, 1780-1787
Publisher:
  • Coll Amer Pathologists, Northfield
Funding / projects:
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)

DOI: 10.5858/arpa.2012-0299-OA

ISSN: 0003-9985

PubMed: 24283859

WoS: 000328263900011

Scopus: 2-s2.0-84892742319
[ Google Scholar ]
7
6
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1912
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Spasić, Slavica
AU  - Videnović-Ivanov, Jelica
AU  - Ivanišević, Jasmina
AU  - Vučinić-Mihailović, Violeta
AU  - Gojković, Tamara
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1912
AB  - Context.-Systemic inflammatory diseases are associated with proatherogenic lipoprotein profile, but there is a lack of information regarding overall distributions of lipoprotein subclasses in sarcoidosis. Objective.-To investigate whether patients with sarcoidosis have altered distributions of plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Design.-Seventy-seven patients with biopsy-proven sarcoidosis (29 with acute and 48 with chronic sarcoidosis) treated with corticosteroids and 77 age-and sex-matched controls were included in the study. Low-density lipoprotein and HDL subclasses were determined by gradient gel electrophoresis, while inflammatory markers and lipid parameters were measured by standard laboratory methods. Results.-Compared to controls, patients had fewer LDL I subclasses (P  lt  .001), but more LDL II and III (P  lt  .001) subclasses. This pattern was evident in both acute and chronic disease groups. Patients also had smaller HDL size (P  lt  .001) and higher proportions of HDL 2a (P = .006) and 3a particles (P = .004). Patients with chronic sarcoidosis had smaller LDL size than those with acute disease (P = .02) and higher proportions of HDL 3a subclasses (P = .04) than controls. In acute sarcoidosis, relative proportions of LDL and HDL particles were associated with levels of inflammatory markers, whereas in chronic disease an association with concentrations of serum lipid parameters was found. Conclusions.-The obtained results demonstrate adverse lipoprotein subfraction profile in sarcoidosis with sustained alterations during disease course. Evaluation of LDL and HDL particles may be helpful in identifying patients with higher cardiovascular risk, at least for prolonged corticosteroid therapy due to chronic disease course.
PB  - Coll Amer Pathologists, Northfield
T2  - Archives of Pathology & Laboratory Medicine
T1  - Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis
VL  - 137
IS  - 12
SP  - 1780
EP  - 1787
DO  - 10.5858/arpa.2012-0299-OA
ER  - 
@article{
author = "Vekić, Jelena and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Spasić, Slavica and Videnović-Ivanov, Jelica and Ivanišević, Jasmina and Vučinić-Mihailović, Violeta and Gojković, Tamara",
year = "2013",
abstract = "Context.-Systemic inflammatory diseases are associated with proatherogenic lipoprotein profile, but there is a lack of information regarding overall distributions of lipoprotein subclasses in sarcoidosis. Objective.-To investigate whether patients with sarcoidosis have altered distributions of plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Design.-Seventy-seven patients with biopsy-proven sarcoidosis (29 with acute and 48 with chronic sarcoidosis) treated with corticosteroids and 77 age-and sex-matched controls were included in the study. Low-density lipoprotein and HDL subclasses were determined by gradient gel electrophoresis, while inflammatory markers and lipid parameters were measured by standard laboratory methods. Results.-Compared to controls, patients had fewer LDL I subclasses (P  lt  .001), but more LDL II and III (P  lt  .001) subclasses. This pattern was evident in both acute and chronic disease groups. Patients also had smaller HDL size (P  lt  .001) and higher proportions of HDL 2a (P = .006) and 3a particles (P = .004). Patients with chronic sarcoidosis had smaller LDL size than those with acute disease (P = .02) and higher proportions of HDL 3a subclasses (P = .04) than controls. In acute sarcoidosis, relative proportions of LDL and HDL particles were associated with levels of inflammatory markers, whereas in chronic disease an association with concentrations of serum lipid parameters was found. Conclusions.-The obtained results demonstrate adverse lipoprotein subfraction profile in sarcoidosis with sustained alterations during disease course. Evaluation of LDL and HDL particles may be helpful in identifying patients with higher cardiovascular risk, at least for prolonged corticosteroid therapy due to chronic disease course.",
publisher = "Coll Amer Pathologists, Northfield",
journal = "Archives of Pathology & Laboratory Medicine",
title = "Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis",
volume = "137",
number = "12",
pages = "1780-1787",
doi = "10.5858/arpa.2012-0299-OA"
}
Vekić, J., Zeljković, A., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Spasić, S., Videnović-Ivanov, J., Ivanišević, J., Vučinić-Mihailović, V.,& Gojković, T.. (2013). Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis. in Archives of Pathology & Laboratory Medicine
Coll Amer Pathologists, Northfield., 137(12), 1780-1787.
https://doi.org/10.5858/arpa.2012-0299-OA
Vekić J, Zeljković A, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Spasić S, Videnović-Ivanov J, Ivanišević J, Vučinić-Mihailović V, Gojković T. Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis. in Archives of Pathology & Laboratory Medicine. 2013;137(12):1780-1787.
doi:10.5858/arpa.2012-0299-OA .
Vekić, Jelena, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Spasić, Slavica, Videnović-Ivanov, Jelica, Ivanišević, Jasmina, Vučinić-Mihailović, Violeta, Gojković, Tamara, "Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis" in Archives of Pathology & Laboratory Medicine, 137, no. 12 (2013):1780-1787,
https://doi.org/10.5858/arpa.2012-0299-OA . .

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