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dc.creatorVekić, Jelena
dc.creatorZeljković, Aleksandra
dc.creatorJelić-Ivanović, Zorana
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorSpasić, Slavica
dc.creatorVidenović-Ivanov, Jelica
dc.creatorIvanišević, Jasmina
dc.creatorVučinić-Mihailović, Violeta
dc.creatorGojković, Tamara
dc.date.accessioned2019-09-02T11:34:04Z
dc.date.available2019-09-02T11:34:04Z
dc.date.issued2013
dc.identifier.issn0003-9985
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1912
dc.description.abstractContext.-Systemic inflammatory diseases are associated with proatherogenic lipoprotein profile, but there is a lack of information regarding overall distributions of lipoprotein subclasses in sarcoidosis. Objective.-To investigate whether patients with sarcoidosis have altered distributions of plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Design.-Seventy-seven patients with biopsy-proven sarcoidosis (29 with acute and 48 with chronic sarcoidosis) treated with corticosteroids and 77 age-and sex-matched controls were included in the study. Low-density lipoprotein and HDL subclasses were determined by gradient gel electrophoresis, while inflammatory markers and lipid parameters were measured by standard laboratory methods. Results.-Compared to controls, patients had fewer LDL I subclasses (P lt .001), but more LDL II and III (P lt .001) subclasses. This pattern was evident in both acute and chronic disease groups. Patients also had smaller HDL size (P lt .001) and higher proportions of HDL 2a (P = .006) and 3a particles (P = .004). Patients with chronic sarcoidosis had smaller LDL size than those with acute disease (P = .02) and higher proportions of HDL 3a subclasses (P = .04) than controls. In acute sarcoidosis, relative proportions of LDL and HDL particles were associated with levels of inflammatory markers, whereas in chronic disease an association with concentrations of serum lipid parameters was found. Conclusions.-The obtained results demonstrate adverse lipoprotein subfraction profile in sarcoidosis with sustained alterations during disease course. Evaluation of LDL and HDL particles may be helpful in identifying patients with higher cardiovascular risk, at least for prolonged corticosteroid therapy due to chronic disease course.en
dc.publisherColl Amer Pathologists, Northfield
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.sourceArchives of Pathology & Laboratory Medicine
dc.titleDistribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosisen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВучинић-Михаиловић, Виолета; Виденовић-Иванов, Јелица; Спасић, Славица; Јелић-Ивановић, Зорана; Иванишевић, Јасмина; Спасојевић-Калимановска, Весна; Гојковић, Тамара; Векић, Јелена; Зељковић, Aлександра;
dc.citation.volume137
dc.citation.issue12
dc.citation.spage1780
dc.citation.epage1787
dc.citation.other137(12): 1780-1787
dc.citation.rankM21
dc.identifier.wos000328263900011
dc.identifier.doi10.5858/arpa.2012-0299-OA
dc.identifier.pmid24283859
dc.identifier.scopus2-s2.0-84892742319
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/686/1910.pdf
dc.identifier.rcubconv_2981
dc.type.versionpublishedVersion


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