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Antimicrobial, antioxidant and anti-inflammatory activity of young shoots of the smoke tree, Cotinus coggygria Scop

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2013
Authors
Marčetić, Mirjana
Božić, Dragana
Milenković, Marina
Malesević, Nevenka
Radulović, Siniša
Kovačević, Nada
Article (Published version)
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Abstract
In this study, we investigated the antimicrobial activity of the young shoots of the smoke tree, Cotinus coggygria Scop., Anacardiaceae. The acetone extract and the derived ethyl acetate fraction effectively inhibited the growth of Gram-positive and Gram-negative bacteria (MIC 25-200 mu g/ml), while the chloroform fraction showed pronounced activity against the yeast Candida albicans (MIC 3.12 mu g/ml). The ethyl acetate fraction exhibited a significant ferric-reducing ability (10.7mmol Fe2+/g extract), a very high DPPH radical scavenging activity (SC50=1.7 mu g/ml) and inhibition of lipid peroxidation (IC50=41.8 mu g/ml). High amounts of total phenolics (929.8mg/g), tannins (833.8mg/g) and flavonoids (35.5mg/g) were determined in the ethyl acetate fraction, which also exerted significant anti-inflammatory (76.7%) and cytotoxic effects (IC50=15.6 mu g/ml). Copyright
Keywords:
Cotinus coggygria / young shoots / antimicrobial activity / antioxidant activity / anti-inflammatory activity
Source:
Phytotherapy Research, 2013, 27, 11, 1658-1663
Publisher:
  • Wiley-Blackwell, Hoboken
Projects:
  • Investigation on the medicinal plants: morphological, chemical and pharmacological characterisation (RS-173021)

DOI: 10.1002/ptr.4919

ISSN: 0951-418X

PubMed: 23280933

WoS: 000328330500010

Scopus: 2-s2.0-84886256365
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1913
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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