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dc.creatorPerišić, Milica
dc.creatorStojić-Vukanić, Zorica
dc.creatorPilipović, Ivan
dc.creatorKosec, Duško
dc.creatorNacka-Aleksić, Mirjana
dc.creatorĐikić, Jasmina
dc.creatorArsenović-Ranin, Nevena
dc.creatorLeposavić, Gordana
dc.date.accessioned2019-09-02T11:34:10Z
dc.date.available2019-09-02T11:34:10Z
dc.date.issued2013
dc.identifier.issn0171-2985
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1915
dc.description.abstractThe study explored the putative role of ovarian hormones in the peripubertal remodelling of peripheral T-cell compartment. Ovariectomy at age of 1 month enhanced the peripubertal rise in CD4+ and CD8+ cell numbers in peripheral blood (PB) and spleen from 2-month-old rats. This reflected maintenance of thymopoietic efficiency at the prepubertal level (judging by numbers of the most mature CD4+ and CD8+ thymocytes and recent thymic emigrants) and alterations in T-cell survival/proliferation in the periphery. Compared with age-matched controls, the frequency of apoptotic cells among CD8+ peripheral blood lymphocytes (PBLs) and CD4+ and CD8+ splenocytes was diminished in ovariectomized (Ox) rats, at least partly, due to lower CD95 surface density. The diminished frequency of the apoptotic T splenocytes could also be associated with the rise in the amount of splenic IL-7 mRNA. Additionally, the latter finding was consistent with the augmented proliferation of CD4+ and CD8+ splenocytes. However, the enhanced proliferation of these cells could also be linked to the rise in IL-2 receptor surface density. This increase was related to the enhanced splenic TNF-alpha mRNA expression. Additionally, ovariectomy led to the phenotypic alterations in the major PBL and splenic T-cell subsets by diminishing/preventing the peripubertal changes in the frequency of cells at distinct stages of post-thymic differentiation/maturation (recent thymic emigrants, mature naive and memory cells), and by decreasing the frequency of NKT cells within peripheral CD8+ subsets. In addition to numerical and phenotypic changes in T-cell compartment (due to the lack of ovarian hormone action at both the thymic and peripheral level), Ox rats exhibited a much larger delayed-type hypersensitivity (DTH) response compared with age-matched controls. This suggested the augmented T-cell-mediated immune response in Ox rats compared with aged-matched controls.en
dc.publisherElsevier Gmbh, Urban & Fischer Verlag, Jena
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145059/RS//
dc.rightsrestrictedAccess
dc.sourceImmunobiology
dc.subjectPeripubertal developmenten
dc.subjectOvarian hormonesen
dc.subjectT-cell proliferationen
dc.subjectT-cell apoptosisen
dc.subjectPeripheral T-cell maturationen
dc.subjectImmunoregulatory T-cellsen
dc.titleRole of ovarian hormones in T-cell homeostasis: From the thymus to the peripheryen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЛепосавић, Гордана; Стојић-Вуканић, Зорица; Aрсеновић-Ранин, Невена; Перишић, Милица; Пилиповић, Иван; Косец, Душко; Нацка-Aлексић, Мирјана; Ђикић, Јасмина;
dc.citation.volume218
dc.citation.issue3
dc.citation.spage353
dc.citation.epage367
dc.citation.other218(3): 353-367
dc.citation.rankM22
dc.identifier.wos000316235700008
dc.identifier.doi10.1016/j.imbio.2012.05.009
dc.identifier.pmid22704521
dc.identifier.scopus2-s2.0-84873258455
dc.identifier.rcubconv_2801
dc.type.versionpublishedVersion


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