dc.creator | Perišić, Milica | |
dc.creator | Stojić-Vukanić, Zorica | |
dc.creator | Pilipović, Ivan | |
dc.creator | Kosec, Duško | |
dc.creator | Nacka-Aleksić, Mirjana | |
dc.creator | Đikić, Jasmina | |
dc.creator | Arsenović-Ranin, Nevena | |
dc.creator | Leposavić, Gordana | |
dc.date.accessioned | 2019-09-02T11:34:10Z | |
dc.date.available | 2019-09-02T11:34:10Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0171-2985 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1915 | |
dc.description.abstract | The study explored the putative role of ovarian hormones in the peripubertal remodelling of peripheral T-cell compartment. Ovariectomy at age of 1 month enhanced the peripubertal rise in CD4+ and CD8+ cell numbers in peripheral blood (PB) and spleen from 2-month-old rats. This reflected maintenance of thymopoietic efficiency at the prepubertal level (judging by numbers of the most mature CD4+ and CD8+ thymocytes and recent thymic emigrants) and alterations in T-cell survival/proliferation in the periphery. Compared with age-matched controls, the frequency of apoptotic cells among CD8+ peripheral blood lymphocytes (PBLs) and CD4+ and CD8+ splenocytes was diminished in ovariectomized (Ox) rats, at least partly, due to lower CD95 surface density. The diminished frequency of the apoptotic T splenocytes could also be associated with the rise in the amount of splenic IL-7 mRNA. Additionally, the latter finding was consistent with the augmented proliferation of CD4+ and CD8+ splenocytes. However, the enhanced proliferation of these cells could also be linked to the rise in IL-2 receptor surface density. This increase was related to the enhanced splenic TNF-alpha mRNA expression. Additionally, ovariectomy led to the phenotypic alterations in the major PBL and splenic T-cell subsets by diminishing/preventing the peripubertal changes in the frequency of cells at distinct stages of post-thymic differentiation/maturation (recent thymic emigrants, mature naive and memory cells), and by decreasing the frequency of NKT cells within peripheral CD8+ subsets. In addition to numerical and phenotypic changes in T-cell compartment (due to the lack of ovarian hormone action at both the thymic and peripheral level), Ox rats exhibited a much larger delayed-type hypersensitivity (DTH) response compared with age-matched controls. This suggested the augmented T-cell-mediated immune response in Ox rats compared with aged-matched controls. | en |
dc.publisher | Elsevier Gmbh, Urban & Fischer Verlag, Jena | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145059/RS// | |
dc.rights | restrictedAccess | |
dc.source | Immunobiology | |
dc.subject | Peripubertal development | en |
dc.subject | Ovarian hormones | en |
dc.subject | T-cell proliferation | en |
dc.subject | T-cell apoptosis | en |
dc.subject | Peripheral T-cell maturation | en |
dc.subject | Immunoregulatory T-cells | en |
dc.title | Role of ovarian hormones in T-cell homeostasis: From the thymus to the periphery | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Лепосавић, Гордана; Стојић-Вуканић, Зорица; Aрсеновић-Ранин, Невена; Перишић, Милица; Пилиповић, Иван; Косец, Душко; Нацка-Aлексић, Мирјана; Ђикић, Јасмина; | |
dc.citation.volume | 218 | |
dc.citation.issue | 3 | |
dc.citation.spage | 353 | |
dc.citation.epage | 367 | |
dc.citation.other | 218(3): 353-367 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000316235700008 | |
dc.identifier.doi | 10.1016/j.imbio.2012.05.009 | |
dc.identifier.pmid | 22704521 | |
dc.identifier.scopus | 2-s2.0-84873258455 | |
dc.type.version | publishedVersion | |