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Organic nitrates in acute coronary syndrome

Organski nitrati u akutnom koronarnom sindromu

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2013
1923.pdf (340.9Kb)
Authors
Stepanović-Petrović, Radica
Article (Published version)
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Abstract
Large randomized trials have shown that routinely applied nitrates (iv or orally), in acute coronary syndrome (ACS) do not reduce significantly mortality. Nevertheless, nitrates still have a place in therapy of certain patients with ACS and they are effective in alleviating ischemia. Nitroglycerin is indicated for the relief of persistent pain and as vasodilator in patients with acute myocardial infarction associated with left ventricular failure. However, in the absence of recurrent angina or congestive heart failure, we do not routinely prescribe them for patients with ACS. Patients with large transmural infarction particularly of the anterior wall, have the most to gain from nitrates in the light of reduction of ventricular remodeling. In such patients nitrates are given as intravenous infusion routinely for 24 to 48 hours. Nitrates should not prescribed beyond the first 48 hours, unless angina or ventricular failure is present.
U velikim kliničkim studijama pokazano je da rutinska primena nitroglicerina (iv ili oralno) u akutnom koronarnom sindromu (AKS) ne smanjuje značajno mortalitet. Međutim, nitrati i dalje imaju svoje mesto u terapiji posebnih grupa bolesnika sa AKS i uspešno se primenjuju za ublažavanje ishemije. Nitroglicerin se primenjuje za otklanjanje perzistentnog bola i kao vazodilatator u pacijenata sa akutnim infarktom miokarda (AIM) i slabošću levog srca. Ukoliko, međutim, pacijent nema rekurentni ishemijski bol ili kongestivnu srčanu slabost, nitrati se ne primenjuju rutinski u pacijenata sa AKS. Pacijenti sa velikim transmuralnim infarktom posebno prednjeg zida imaju najviše koristi od primene nitrata u svetlu smanjenja remodelovanja komora. U takvih pacijenata se primenjuju nitrati u obliku intravenske infuzije rutinski tokom 24 do 48 sati. Treba nastaviti davanje nitrata duže od 48 sati bolesnicima koji imaju rekurentnu ishemiju ili slabost srca.
Keywords:
acute coronary syndrome / organic nitrates / mechanisms of clinical effects / akutni koronarni sindrom / organski nitrati / mehanizmi kliničkih dejstava
Source:
Acta clinica, 2013, 13, 1, 140-155
Publisher:
  • Klinički centar Srbije, Beograd

ISSN: 1451-1134

[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_farfar_1925
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1925
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Stepanović-Petrović, Radica
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1925
AB  - Large randomized trials have shown that routinely applied nitrates (iv or orally), in acute coronary syndrome (ACS) do not reduce significantly mortality. Nevertheless, nitrates still have a place in therapy of certain patients with ACS and they are effective in alleviating ischemia. Nitroglycerin is indicated for the relief of persistent pain and as vasodilator in patients with acute myocardial infarction associated with left ventricular failure. However, in the absence of recurrent angina or congestive heart failure, we do not routinely prescribe them for patients with ACS. Patients with large transmural infarction particularly of the anterior wall, have the most to gain from nitrates in the light of reduction of ventricular remodeling. In such patients nitrates are given as intravenous infusion routinely for 24 to 48 hours. Nitrates should not prescribed beyond the first 48 hours, unless angina or ventricular failure is present.
AB  - U velikim kliničkim studijama pokazano je da rutinska primena nitroglicerina (iv ili oralno) u akutnom koronarnom sindromu (AKS) ne smanjuje značajno mortalitet. Međutim, nitrati i dalje imaju svoje mesto u terapiji posebnih grupa bolesnika sa AKS i uspešno se primenjuju za ublažavanje ishemije. Nitroglicerin se primenjuje za otklanjanje perzistentnog bola i kao vazodilatator u pacijenata sa akutnim infarktom miokarda (AIM) i slabošću levog srca. Ukoliko, međutim, pacijent nema rekurentni ishemijski bol ili kongestivnu srčanu slabost, nitrati se ne primenjuju rutinski u pacijenata sa AKS. Pacijenti sa velikim transmuralnim infarktom posebno prednjeg zida imaju najviše koristi od primene nitrata u svetlu smanjenja remodelovanja komora. U takvih pacijenata se primenjuju nitrati u obliku intravenske infuzije rutinski tokom 24 do 48 sati. Treba nastaviti davanje nitrata duže od 48 sati bolesnicima koji imaju rekurentnu ishemiju ili slabost srca.
PB  - Klinički centar Srbije, Beograd
T2  - Acta clinica
T1  - Organic nitrates in acute coronary syndrome
T1  - Organski nitrati u akutnom koronarnom sindromu
VL  - 13
IS  - 1
SP  - 140
EP  - 155
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1925
ER  - 
@article{
author = "Stepanović-Petrović, Radica",
year = "2013",
abstract = "Large randomized trials have shown that routinely applied nitrates (iv or orally), in acute coronary syndrome (ACS) do not reduce significantly mortality. Nevertheless, nitrates still have a place in therapy of certain patients with ACS and they are effective in alleviating ischemia. Nitroglycerin is indicated for the relief of persistent pain and as vasodilator in patients with acute myocardial infarction associated with left ventricular failure. However, in the absence of recurrent angina or congestive heart failure, we do not routinely prescribe them for patients with ACS. Patients with large transmural infarction particularly of the anterior wall, have the most to gain from nitrates in the light of reduction of ventricular remodeling. In such patients nitrates are given as intravenous infusion routinely for 24 to 48 hours. Nitrates should not prescribed beyond the first 48 hours, unless angina or ventricular failure is present., U velikim kliničkim studijama pokazano je da rutinska primena nitroglicerina (iv ili oralno) u akutnom koronarnom sindromu (AKS) ne smanjuje značajno mortalitet. Međutim, nitrati i dalje imaju svoje mesto u terapiji posebnih grupa bolesnika sa AKS i uspešno se primenjuju za ublažavanje ishemije. Nitroglicerin se primenjuje za otklanjanje perzistentnog bola i kao vazodilatator u pacijenata sa akutnim infarktom miokarda (AIM) i slabošću levog srca. Ukoliko, međutim, pacijent nema rekurentni ishemijski bol ili kongestivnu srčanu slabost, nitrati se ne primenjuju rutinski u pacijenata sa AKS. Pacijenti sa velikim transmuralnim infarktom posebno prednjeg zida imaju najviše koristi od primene nitrata u svetlu smanjenja remodelovanja komora. U takvih pacijenata se primenjuju nitrati u obliku intravenske infuzije rutinski tokom 24 do 48 sati. Treba nastaviti davanje nitrata duže od 48 sati bolesnicima koji imaju rekurentnu ishemiju ili slabost srca.",
publisher = "Klinički centar Srbije, Beograd",
journal = "Acta clinica",
title = "Organic nitrates in acute coronary syndrome, Organski nitrati u akutnom koronarnom sindromu",
volume = "13",
number = "1",
pages = "140-155",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1925"
}
Stepanović-Petrović, R.. (2013). Organic nitrates in acute coronary syndrome. in Acta clinica
Klinički centar Srbije, Beograd., 13(1), 140-155.
https://hdl.handle.net/21.15107/rcub_farfar_1925
Stepanović-Petrović R. Organic nitrates in acute coronary syndrome. in Acta clinica. 2013;13(1):140-155.
https://hdl.handle.net/21.15107/rcub_farfar_1925 .
Stepanović-Petrović, Radica, "Organic nitrates in acute coronary syndrome" in Acta clinica, 13, no. 1 (2013):140-155,
https://hdl.handle.net/21.15107/rcub_farfar_1925 .

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