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Organski nitrati u akutnom koronarnom sindromu

dc.creatorStepanović-Petrović, Radica
dc.date.accessioned2019-09-02T11:34:27Z
dc.date.available2019-09-02T11:34:27Z
dc.date.issued2013
dc.identifier.issn1451-1134
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1925
dc.description.abstractLarge randomized trials have shown that routinely applied nitrates (iv or orally), in acute coronary syndrome (ACS) do not reduce significantly mortality. Nevertheless, nitrates still have a place in therapy of certain patients with ACS and they are effective in alleviating ischemia. Nitroglycerin is indicated for the relief of persistent pain and as vasodilator in patients with acute myocardial infarction associated with left ventricular failure. However, in the absence of recurrent angina or congestive heart failure, we do not routinely prescribe them for patients with ACS. Patients with large transmural infarction particularly of the anterior wall, have the most to gain from nitrates in the light of reduction of ventricular remodeling. In such patients nitrates are given as intravenous infusion routinely for 24 to 48 hours. Nitrates should not prescribed beyond the first 48 hours, unless angina or ventricular failure is present.en
dc.description.abstractU velikim kliničkim studijama pokazano je da rutinska primena nitroglicerina (iv ili oralno) u akutnom koronarnom sindromu (AKS) ne smanjuje značajno mortalitet. Međutim, nitrati i dalje imaju svoje mesto u terapiji posebnih grupa bolesnika sa AKS i uspešno se primenjuju za ublažavanje ishemije. Nitroglicerin se primenjuje za otklanjanje perzistentnog bola i kao vazodilatator u pacijenata sa akutnim infarktom miokarda (AIM) i slabošću levog srca. Ukoliko, međutim, pacijent nema rekurentni ishemijski bol ili kongestivnu srčanu slabost, nitrati se ne primenjuju rutinski u pacijenata sa AKS. Pacijenti sa velikim transmuralnim infarktom posebno prednjeg zida imaju najviše koristi od primene nitrata u svetlu smanjenja remodelovanja komora. U takvih pacijenata se primenjuju nitrati u obliku intravenske infuzije rutinski tokom 24 do 48 sati. Treba nastaviti davanje nitrata duže od 48 sati bolesnicima koji imaju rekurentnu ishemiju ili slabost srca.sr
dc.publisherKlinički centar Srbije, Beograd
dc.rightsopenAccess
dc.sourceActa clinica
dc.subjectacute coronary syndromeen
dc.subjectorganic nitratesen
dc.subjectmechanisms of clinical effectsen
dc.subjectakutni koronarni sindromsr
dc.subjectorganski nitratisr
dc.subjectmehanizmi kliničkih dejstavasr
dc.titleOrganic nitrates in acute coronary syndromeen
dc.titleOrganski nitrati u akutnom koronarnom sindromusr
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтепановић-Петровић, Радица; Органски нитрати у акутном коронарном синдрому; Органски нитрати у акутном коронарном синдрому;
dc.citation.volume13
dc.citation.issue1
dc.citation.spage140
dc.citation.epage155
dc.citation.other13(1): 140-155
dc.citation.rankM52
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/697/1923.pdf
dc.identifier.rcubconv_1013
dc.type.versionpublishedVersion


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