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dc.creatorBrborić, Jasmina
dc.creatorJovanović, M.S.
dc.creatorVranješ-Đurić, Sanja D.
dc.creatorČudina, Olivera
dc.creatorMarković, Bojan
dc.creatorVladimirov, Sote
dc.date.accessioned2019-09-02T11:34:36Z
dc.date.available2019-09-02T11:34:36Z
dc.date.issued2013
dc.identifier.issn0969-8043
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1932
dc.description.abstractThe partition coefficients (log P) of theoretically possible alkyliodinated iminodiacetic acid (IDA) derivatives and commercial IDA derivatives were calculated using two computer programs: ChemSketch Log P and ChemOffice Ultra. Newly synthesized ligands (DIETHYLIODIDA and DIISOPROPYLIODIDA) with the highest calculated log P were labeled with technetium-99m. The biodistribution and the influence of bilirubin on their biokinetics were investigated in rats and compared to corresponding results for commercial Tc-99m-BROMIDA. Log P of Tc-99m-complexes of synthesized ligands were determined experimentally as well as the protein binding. In comparison to Tc-99m-BROMIDA, Tc-99m-DIETHYLIODIDA has: (a) better biliary excretion (2.76 +/- 0.15%ID/g versus 1.83 +/- 0.10%ID/g); (b) faster hepatic clearance (2.90 +/- 0.21%ID/g versus 7.47 +/- 0.70%ID/g) and decreased biliary excretion (for 14% versus 22%) in conditions of hyperbilirubinemia after 15 min. It is proved that Tc-99m-DIISOPROPYLIODIDA has a prolonged hepatic transit time and decreased biliary excretion.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS//
dc.rightsrestrictedAccess
dc.sourceApplied Radiation and Isotopes
dc.subjectDIETHYLIODIDAen
dc.subjectDIISOPROPYLIODIDAen
dc.subjectBROMIDAen
dc.subjectLipophilicityen
dc.subjectHepatobiliary scintigraphyen
dc.titleThe effect of lipophilicity on the hepatobiliary properties of iminodiacetic acid derivatives in the conditions of hyperbilirubinemiaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЧудина, Оливера; Владимиров, Соте; Марковић, Бојан; Јовановић, М.С.; Врањеш-Ђурић, Сања Д.; Брборић, Јасмина;
dc.citation.volume74
dc.citation.spage31
dc.citation.epage35
dc.citation.other74: 31-35
dc.citation.rankM22
dc.identifier.wos000316978400007
dc.identifier.doi10.1016/j.apradiso.2012.12.014
dc.identifier.pmid23353095
dc.identifier.scopus2-s2.0-84872957304
dc.identifier.rcubconv_2812
dc.type.versionpublishedVersion


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