Apoptosis, annexin a5 and anti-Annexin a5 antibodies in the antiphospholipid syndrome
Abstract
It has been proposed that apoptosis is one of the mechanisms involved in the generation of antiphospholipid antibodies. The presence of antiphospholipid antibodies is the main laboratory criterion for a definite diagnosis of the antiphospholipid syndrome. Annexinopathies are disorders characterized by deregulation of annexins expression levels and function. Annexin A5 has been used as an agent for molecular imaging techniques (visualization of phosphatidylserine-expressing apoptotic cells) in vitro and in vivo in animal models and in patients (injection of human recombinant anxA5 into the patient's circulation). Although the determination of titers of anti-annexin A5 antibodies is not mandatory for the diagnosis of the antiphospholipid syndrome, it was reported that patients with primary antiphospholipid syndrome with a history of recurrent abortions had elevated titers of anti-annexin A5 antibodies, while the presence of thromboses was not associated with elevated levels of these anti...bodies.
Keywords:
apoptosis / annexin A5 / anti-annexin A5 antibodies / antiphospholipid syndromeSource:
Journal of Medical Biochemistry, 2013, 32, 2, 89-95Publisher:
- Društvo medicinskih biohemičara Srbije, Beograd i Versita
Funding / projects:
- Biomarkers of organ damage and dysfunction (RS-175036)
DOI: 10.2478/jomb-2013-0014
ISSN: 1452-8258
WoS: 000317253000001
Scopus: 2-s2.0-84881525810
Collections
Institution/Community
PharmacyTY - JOUR AU - Becarević, Mirjana AU - Ignjatović, Svetlana AU - Majkić-Singh, Nada PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1934 AB - It has been proposed that apoptosis is one of the mechanisms involved in the generation of antiphospholipid antibodies. The presence of antiphospholipid antibodies is the main laboratory criterion for a definite diagnosis of the antiphospholipid syndrome. Annexinopathies are disorders characterized by deregulation of annexins expression levels and function. Annexin A5 has been used as an agent for molecular imaging techniques (visualization of phosphatidylserine-expressing apoptotic cells) in vitro and in vivo in animal models and in patients (injection of human recombinant anxA5 into the patient's circulation). Although the determination of titers of anti-annexin A5 antibodies is not mandatory for the diagnosis of the antiphospholipid syndrome, it was reported that patients with primary antiphospholipid syndrome with a history of recurrent abortions had elevated titers of anti-annexin A5 antibodies, while the presence of thromboses was not associated with elevated levels of these antibodies. PB - Društvo medicinskih biohemičara Srbije, Beograd i Versita T2 - Journal of Medical Biochemistry T1 - Apoptosis, annexin a5 and anti-Annexin a5 antibodies in the antiphospholipid syndrome VL - 32 IS - 2 SP - 89 EP - 95 DO - 10.2478/jomb-2013-0014 ER -
@article{ author = "Becarević, Mirjana and Ignjatović, Svetlana and Majkić-Singh, Nada", year = "2013", abstract = "It has been proposed that apoptosis is one of the mechanisms involved in the generation of antiphospholipid antibodies. The presence of antiphospholipid antibodies is the main laboratory criterion for a definite diagnosis of the antiphospholipid syndrome. Annexinopathies are disorders characterized by deregulation of annexins expression levels and function. Annexin A5 has been used as an agent for molecular imaging techniques (visualization of phosphatidylserine-expressing apoptotic cells) in vitro and in vivo in animal models and in patients (injection of human recombinant anxA5 into the patient's circulation). Although the determination of titers of anti-annexin A5 antibodies is not mandatory for the diagnosis of the antiphospholipid syndrome, it was reported that patients with primary antiphospholipid syndrome with a history of recurrent abortions had elevated titers of anti-annexin A5 antibodies, while the presence of thromboses was not associated with elevated levels of these antibodies.", publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita", journal = "Journal of Medical Biochemistry", title = "Apoptosis, annexin a5 and anti-Annexin a5 antibodies in the antiphospholipid syndrome", volume = "32", number = "2", pages = "89-95", doi = "10.2478/jomb-2013-0014" }
Becarević, M., Ignjatović, S.,& Majkić-Singh, N.. (2013). Apoptosis, annexin a5 and anti-Annexin a5 antibodies in the antiphospholipid syndrome. in Journal of Medical Biochemistry Društvo medicinskih biohemičara Srbije, Beograd i Versita., 32(2), 89-95. https://doi.org/10.2478/jomb-2013-0014
Becarević M, Ignjatović S, Majkić-Singh N. Apoptosis, annexin a5 and anti-Annexin a5 antibodies in the antiphospholipid syndrome. in Journal of Medical Biochemistry. 2013;32(2):89-95. doi:10.2478/jomb-2013-0014 .
Becarević, Mirjana, Ignjatović, Svetlana, Majkić-Singh, Nada, "Apoptosis, annexin a5 and anti-Annexin a5 antibodies in the antiphospholipid syndrome" in Journal of Medical Biochemistry, 32, no. 2 (2013):89-95, https://doi.org/10.2478/jomb-2013-0014 . .