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Apoptosis, annexin a5 and anti-Annexin a5 antibodies in the antiphospholipid syndrome

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2013
1932.pdf (62.11Kb)
Authors
Becarević, Mirjana
Ignjatović, Svetlana
Majkić-Singh, Nada
Article (Published version)
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Abstract
It has been proposed that apoptosis is one of the mechanisms involved in the generation of antiphospholipid antibodies. The presence of antiphospholipid antibodies is the main laboratory criterion for a definite diagnosis of the antiphospholipid syndrome. Annexinopathies are disorders characterized by deregulation of annexins expression levels and function. Annexin A5 has been used as an agent for molecular imaging techniques (visualization of phosphatidylserine-expressing apoptotic cells) in vitro and in vivo in animal models and in patients (injection of human recombinant anxA5 into the patient's circulation). Although the determination of titers of anti-annexin A5 antibodies is not mandatory for the diagnosis of the antiphospholipid syndrome, it was reported that patients with primary antiphospholipid syndrome with a history of recurrent abortions had elevated titers of anti-annexin A5 antibodies, while the presence of thromboses was not associated with elevated levels of these anti...bodies.

Keywords:
apoptosis / annexin A5 / anti-annexin A5 antibodies / antiphospholipid syndrome
Source:
Journal of Medical Biochemistry, 2013, 32, 2, 89-95
Publisher:
  • Društvo medicinskih biohemičara Srbije, Beograd i Versita
Funding / projects:
  • Biomarkers of organ damage and dysfunction (RS-175036)

DOI: 10.2478/jomb-2013-0014

ISSN: 1452-8258

WoS: 000317253000001

Scopus: 2-s2.0-84881525810
[ Google Scholar ]
2
2
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1934
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Becarević, Mirjana
AU  - Ignjatović, Svetlana
AU  - Majkić-Singh, Nada
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1934
AB  - It has been proposed that apoptosis is one of the mechanisms involved in the generation of antiphospholipid antibodies. The presence of antiphospholipid antibodies is the main laboratory criterion for a definite diagnosis of the antiphospholipid syndrome. Annexinopathies are disorders characterized by deregulation of annexins expression levels and function. Annexin A5 has been used as an agent for molecular imaging techniques (visualization of phosphatidylserine-expressing apoptotic cells) in vitro and in vivo in animal models and in patients (injection of human recombinant anxA5 into the patient's circulation). Although the determination of titers of anti-annexin A5 antibodies is not mandatory for the diagnosis of the antiphospholipid syndrome, it was reported that patients with primary antiphospholipid syndrome with a history of recurrent abortions had elevated titers of anti-annexin A5 antibodies, while the presence of thromboses was not associated with elevated levels of these antibodies.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Apoptosis, annexin a5 and anti-Annexin a5 antibodies in the antiphospholipid syndrome
VL  - 32
IS  - 2
SP  - 89
EP  - 95
DO  - 10.2478/jomb-2013-0014
ER  - 
@article{
author = "Becarević, Mirjana and Ignjatović, Svetlana and Majkić-Singh, Nada",
year = "2013",
abstract = "It has been proposed that apoptosis is one of the mechanisms involved in the generation of antiphospholipid antibodies. The presence of antiphospholipid antibodies is the main laboratory criterion for a definite diagnosis of the antiphospholipid syndrome. Annexinopathies are disorders characterized by deregulation of annexins expression levels and function. Annexin A5 has been used as an agent for molecular imaging techniques (visualization of phosphatidylserine-expressing apoptotic cells) in vitro and in vivo in animal models and in patients (injection of human recombinant anxA5 into the patient's circulation). Although the determination of titers of anti-annexin A5 antibodies is not mandatory for the diagnosis of the antiphospholipid syndrome, it was reported that patients with primary antiphospholipid syndrome with a history of recurrent abortions had elevated titers of anti-annexin A5 antibodies, while the presence of thromboses was not associated with elevated levels of these antibodies.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Apoptosis, annexin a5 and anti-Annexin a5 antibodies in the antiphospholipid syndrome",
volume = "32",
number = "2",
pages = "89-95",
doi = "10.2478/jomb-2013-0014"
}
Becarević, M., Ignjatović, S.,& Majkić-Singh, N.. (2013). Apoptosis, annexin a5 and anti-Annexin a5 antibodies in the antiphospholipid syndrome. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 32(2), 89-95.
https://doi.org/10.2478/jomb-2013-0014
Becarević M, Ignjatović S, Majkić-Singh N. Apoptosis, annexin a5 and anti-Annexin a5 antibodies in the antiphospholipid syndrome. in Journal of Medical Biochemistry. 2013;32(2):89-95.
doi:10.2478/jomb-2013-0014 .
Becarević, Mirjana, Ignjatović, Svetlana, Majkić-Singh, Nada, "Apoptosis, annexin a5 and anti-Annexin a5 antibodies in the antiphospholipid syndrome" in Journal of Medical Biochemistry, 32, no. 2 (2013):89-95,
https://doi.org/10.2478/jomb-2013-0014 . .

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