A simple and reliable novel kinetic method for the determination of piroxicam (PX) was proposed and validated. For quantitative determination of PX, the Bray-Liebhafsky (BL) oscillatory reaction was used in a stable non-equilibrium stationary state close to the bifurcation point. Under the optimized reaction conditions (T = 55.0A degrees C, [H2SO4](0) = 7.60x10(-2) mol L-1, [KIO3](0) = 5.90x10(-2) mol L-1, [H2O2](0) = 1.50x10(-1) mol L-1 and j (0) = 2.95x10(-2) min(-1)), the linear relationship between maximal potential shift Delta E (m) , and PX concentration was obtained in the concentration range 11.2-480.5 A mu g mL(-1) with a detection limit of 9.9 A mu g mL(-1). The method had a rather good sample throughput of 25 samples h(-1) with a precision RSD = 4.7% as well as recoveries RCV a parts per thousand currency sign 104.4%. Applicability of the proposed method to the direct determination of piroxicam in different pharmaceutical formulations (tablets, ampoules and gel) was demonstr...ated.
TY - JOUR
AU - Pejić, Nataša
AU - Sarap, Nataša B.
AU - Maksimović, Jelena
AU - Anić, Slobodan
AU - Kolar-Anić, Ljiljana
PY - 2013
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1940
AB - A simple and reliable novel kinetic method for the determination of piroxicam (PX) was proposed and validated. For quantitative determination of PX, the Bray-Liebhafsky (BL) oscillatory reaction was used in a stable non-equilibrium stationary state close to the bifurcation point. Under the optimized reaction conditions (T = 55.0A degrees C, [H2SO4](0) = 7.60x10(-2) mol L-1, [KIO3](0) = 5.90x10(-2) mol L-1, [H2O2](0) = 1.50x10(-1) mol L-1 and j (0) = 2.95x10(-2) min(-1)), the linear relationship between maximal potential shift Delta E (m) , and PX concentration was obtained in the concentration range 11.2-480.5 A mu g mL(-1) with a detection limit of 9.9 A mu g mL(-1). The method had a rather good sample throughput of 25 samples h(-1) with a precision RSD = 4.7% as well as recoveries RCV a parts per thousand currency sign 104.4%. Applicability of the proposed method to the direct determination of piroxicam in different pharmaceutical formulations (tablets, ampoules and gel) was demonstrated.
PB - Versita, Warsaw
T2 - Central European Journal of Chemistry
T1 - Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system
VL - 11
IS - 2
SP - 180
EP - 188
DO - 10.2478/s11532-012-0146-7
ER -
@article{
author = "Pejić, Nataša and Sarap, Nataša B. and Maksimović, Jelena and Anić, Slobodan and Kolar-Anić, Ljiljana",
year = "2013",
abstract = "A simple and reliable novel kinetic method for the determination of piroxicam (PX) was proposed and validated. For quantitative determination of PX, the Bray-Liebhafsky (BL) oscillatory reaction was used in a stable non-equilibrium stationary state close to the bifurcation point. Under the optimized reaction conditions (T = 55.0A degrees C, [H2SO4](0) = 7.60x10(-2) mol L-1, [KIO3](0) = 5.90x10(-2) mol L-1, [H2O2](0) = 1.50x10(-1) mol L-1 and j (0) = 2.95x10(-2) min(-1)), the linear relationship between maximal potential shift Delta E (m) , and PX concentration was obtained in the concentration range 11.2-480.5 A mu g mL(-1) with a detection limit of 9.9 A mu g mL(-1). The method had a rather good sample throughput of 25 samples h(-1) with a precision RSD = 4.7% as well as recoveries RCV a parts per thousand currency sign 104.4%. Applicability of the proposed method to the direct determination of piroxicam in different pharmaceutical formulations (tablets, ampoules and gel) was demonstrated.",
publisher = "Versita, Warsaw",
journal = "Central European Journal of Chemistry",
title = "Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system",
volume = "11",
number = "2",
pages = "180-188",
doi = "10.2478/s11532-012-0146-7"
}
Pejić, N., Sarap, N. B., Maksimović, J., Anić, S.,& Kolar-Anić, L.. (2013). Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system. in Central European Journal of Chemistry
Versita, Warsaw., 11(2), 180-188.
https://doi.org/10.2478/s11532-012-0146-7
Pejić N, Sarap NB, Maksimović J, Anić S, Kolar-Anić L. Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system. in Central European Journal of Chemistry. 2013;11(2):180-188.
doi:10.2478/s11532-012-0146-7 .
Pejić, Nataša, Sarap, Nataša B., Maksimović, Jelena, Anić, Slobodan, Kolar-Anić, Ljiljana, "Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system" in Central European Journal of Chemistry, 11, no. 2 (2013):180-188,
https://doi.org/10.2478/s11532-012-0146-7 . .
