The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction
Само за регистроване кориснике
2013
Аутори
Bazov, IgorKononenko, Olga
Watanabe, Hiroyuki
Kuntić, Vesna
Sarkisyan, Daniil
Taqi, Malik M.
Hussain, Muhammad Z.
Nyberg, Fred
Yakovleva, Tatjana
Bakalkin, Georgy
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The endogenous opioid system (EOS) plays a critical role in addictive processes. Molecular dysregulations in this system may be specific for different stages of addiction cycle and neurocircuitries involved and therefore may differentially contribute to the initiation and maintenance of addiction. Here we evaluated whether the EOS is altered in brain areas involved in cognitive control of addiction including the dorsolateral prefrontal cortex (dl-PFC), orbitofrontal cortex (OFC) and hippocampus in human alcohol-dependent subjects. Levels of EOS mRNAs were measured by quantitative reverse transcription-polymerase chain reaction (qRT-PCR), and levels of dynorphins by radioimmunoassay (RIA) in post-mortem specimens obtained from 14 alcoholics and 14 controls. Prodynorphin mRNA and dynorphins in dl-PFC, ?-opioid receptor mRNA in OFC and dynorphins in hippocampus were up-regulated in alcoholics. No significant changes in expression of proenkephalin, and mu- and d-opioid receptors were evide...nt; pro-opiomelanocortin mRNA levels were below the detection limit. Activation of the ?-opioid receptor by up-regulated dynorphins in alcoholics may underlie in part neurocognitive dysfunctions relevant for addiction and disrupted inhibitory control.
Кључне речи:
Alcohol dependence / dynorphin / endogenous opioid system / human brain / -opioid receptor / prodynorphinИзвор:
Addiction Biology, 2013, 18, 1, 161-169Издавач:
- Wiley-Blackwell, Hoboken
Финансирање / пројекти:
- Swedish Council for Working Life and Social Research (FAS)
- AFA Forsakring
- Swedish Science Research Council
- Swedish Institute Visby Program
DOI: 10.1111/j.1369-1600.2011.00366.x
ISSN: 1355-6215
PubMed: 21955155
WoS: 000312740500016
Scopus: 2-s2.0-84871750715
Институција/група
PharmacyTY - JOUR AU - Bazov, Igor AU - Kononenko, Olga AU - Watanabe, Hiroyuki AU - Kuntić, Vesna AU - Sarkisyan, Daniil AU - Taqi, Malik M. AU - Hussain, Muhammad Z. AU - Nyberg, Fred AU - Yakovleva, Tatjana AU - Bakalkin, Georgy PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1942 AB - The endogenous opioid system (EOS) plays a critical role in addictive processes. Molecular dysregulations in this system may be specific for different stages of addiction cycle and neurocircuitries involved and therefore may differentially contribute to the initiation and maintenance of addiction. Here we evaluated whether the EOS is altered in brain areas involved in cognitive control of addiction including the dorsolateral prefrontal cortex (dl-PFC), orbitofrontal cortex (OFC) and hippocampus in human alcohol-dependent subjects. Levels of EOS mRNAs were measured by quantitative reverse transcription-polymerase chain reaction (qRT-PCR), and levels of dynorphins by radioimmunoassay (RIA) in post-mortem specimens obtained from 14 alcoholics and 14 controls. Prodynorphin mRNA and dynorphins in dl-PFC, ?-opioid receptor mRNA in OFC and dynorphins in hippocampus were up-regulated in alcoholics. No significant changes in expression of proenkephalin, and mu- and d-opioid receptors were evident; pro-opiomelanocortin mRNA levels were below the detection limit. Activation of the ?-opioid receptor by up-regulated dynorphins in alcoholics may underlie in part neurocognitive dysfunctions relevant for addiction and disrupted inhibitory control. PB - Wiley-Blackwell, Hoboken T2 - Addiction Biology T1 - The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction VL - 18 IS - 1 SP - 161 EP - 169 DO - 10.1111/j.1369-1600.2011.00366.x ER -
@article{ author = "Bazov, Igor and Kononenko, Olga and Watanabe, Hiroyuki and Kuntić, Vesna and Sarkisyan, Daniil and Taqi, Malik M. and Hussain, Muhammad Z. and Nyberg, Fred and Yakovleva, Tatjana and Bakalkin, Georgy", year = "2013", abstract = "The endogenous opioid system (EOS) plays a critical role in addictive processes. Molecular dysregulations in this system may be specific for different stages of addiction cycle and neurocircuitries involved and therefore may differentially contribute to the initiation and maintenance of addiction. Here we evaluated whether the EOS is altered in brain areas involved in cognitive control of addiction including the dorsolateral prefrontal cortex (dl-PFC), orbitofrontal cortex (OFC) and hippocampus in human alcohol-dependent subjects. Levels of EOS mRNAs were measured by quantitative reverse transcription-polymerase chain reaction (qRT-PCR), and levels of dynorphins by radioimmunoassay (RIA) in post-mortem specimens obtained from 14 alcoholics and 14 controls. Prodynorphin mRNA and dynorphins in dl-PFC, ?-opioid receptor mRNA in OFC and dynorphins in hippocampus were up-regulated in alcoholics. No significant changes in expression of proenkephalin, and mu- and d-opioid receptors were evident; pro-opiomelanocortin mRNA levels were below the detection limit. Activation of the ?-opioid receptor by up-regulated dynorphins in alcoholics may underlie in part neurocognitive dysfunctions relevant for addiction and disrupted inhibitory control.", publisher = "Wiley-Blackwell, Hoboken", journal = "Addiction Biology", title = "The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction", volume = "18", number = "1", pages = "161-169", doi = "10.1111/j.1369-1600.2011.00366.x" }
Bazov, I., Kononenko, O., Watanabe, H., Kuntić, V., Sarkisyan, D., Taqi, M. M., Hussain, M. Z., Nyberg, F., Yakovleva, T.,& Bakalkin, G.. (2013). The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction. in Addiction Biology Wiley-Blackwell, Hoboken., 18(1), 161-169. https://doi.org/10.1111/j.1369-1600.2011.00366.x
Bazov I, Kononenko O, Watanabe H, Kuntić V, Sarkisyan D, Taqi MM, Hussain MZ, Nyberg F, Yakovleva T, Bakalkin G. The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction. in Addiction Biology. 2013;18(1):161-169. doi:10.1111/j.1369-1600.2011.00366.x .
Bazov, Igor, Kononenko, Olga, Watanabe, Hiroyuki, Kuntić, Vesna, Sarkisyan, Daniil, Taqi, Malik M., Hussain, Muhammad Z., Nyberg, Fred, Yakovleva, Tatjana, Bakalkin, Georgy, "The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction" in Addiction Biology, 18, no. 1 (2013):161-169, https://doi.org/10.1111/j.1369-1600.2011.00366.x . .