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dc.creatorBazov, Igor
dc.creatorKononenko, Olga
dc.creatorWatanabe, Hiroyuki
dc.creatorKuntić, Vesna
dc.creatorSarkisyan, Daniil
dc.creatorTaqi, Malik M.
dc.creatorHussain, Muhammad Z.
dc.creatorNyberg, Fred
dc.creatorYakovleva, Tatjana
dc.creatorBakalkin, Georgy
dc.date.accessioned2019-09-02T11:34:52Z
dc.date.available2019-09-02T11:34:52Z
dc.date.issued2013
dc.identifier.issn1355-6215
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1942
dc.description.abstractThe endogenous opioid system (EOS) plays a critical role in addictive processes. Molecular dysregulations in this system may be specific for different stages of addiction cycle and neurocircuitries involved and therefore may differentially contribute to the initiation and maintenance of addiction. Here we evaluated whether the EOS is altered in brain areas involved in cognitive control of addiction including the dorsolateral prefrontal cortex (dl-PFC), orbitofrontal cortex (OFC) and hippocampus in human alcohol-dependent subjects. Levels of EOS mRNAs were measured by quantitative reverse transcription-polymerase chain reaction (qRT-PCR), and levels of dynorphins by radioimmunoassay (RIA) in post-mortem specimens obtained from 14 alcoholics and 14 controls. Prodynorphin mRNA and dynorphins in dl-PFC, ?-opioid receptor mRNA in OFC and dynorphins in hippocampus were up-regulated in alcoholics. No significant changes in expression of proenkephalin, and mu- and d-opioid receptors were evident; pro-opiomelanocortin mRNA levels were below the detection limit. Activation of the ?-opioid receptor by up-regulated dynorphins in alcoholics may underlie in part neurocognitive dysfunctions relevant for addiction and disrupted inhibitory control.en
dc.publisherWiley-Blackwell, Hoboken
dc.relationSwedish Council for Working Life and Social Research (FAS)
dc.relationAFA Forsakring
dc.relationSwedish Science Research Council
dc.relationSwedish Institute Visby Program
dc.rightsrestrictedAccess
dc.sourceAddiction Biology
dc.subjectAlcohol dependenceen
dc.subjectdynorphinen
dc.subjectendogenous opioid systemen
dc.subjecthuman brainen
dc.subject-opioid receptoren
dc.subjectprodynorphinen
dc.titleThe endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addictionen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБазов, Игор; Бакалкин, Георгy; Wатанабе, Хироyуки; Кононенко, Олга; Кунтић, Весна; Саркисyан, Даниил; Таqи, Малик М.; Хуссаин, Мухаммад З.; Нyберг, Фред; Yаковлева, Татјана;
dc.citation.volume18
dc.citation.issue1
dc.citation.spage161
dc.citation.epage169
dc.citation.other18(1): 161-169
dc.citation.rankM21a
dc.identifier.wos000312740500016
dc.identifier.doi10.1111/j.1369-1600.2011.00366.x
dc.identifier.pmid21955155
dc.identifier.scopus2-s2.0-84871750715
dc.type.versionpublishedVersion


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