Show simple item record

dc.creatorKotur-Stevuljević, Jelena
dc.creatorPeco-Antić, Amira
dc.creatorSpasić, Slavica
dc.creatorStefanović, Aleksandra
dc.creatorParipović, Dušan
dc.creatorKostić, Mirjana
dc.creatorVasić, Dragan
dc.creatorVujović, Ana
dc.creatorJelić-Ivanović, Zorana
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorKornić-Ristovski, Danijela
dc.date.accessioned2019-09-02T11:34:57Z
dc.date.available2019-09-02T11:34:57Z
dc.date.issued2013
dc.identifier.issn0931-041X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1943
dc.description.abstractThe roles of dyslipidemia and oxidative stress in the early phases of atherosclerosis were tested in children with chronic kidney disease (CKD). Intima media thickness of common carotid arteries (cIMT) is used as a measure of early atherosclerosis. Fifty-two pediatric CKD patients were enrolled in the study (10 with chronic renal failure [CRF], 22 with a renal transplant [RT], 20 with chronic hemodialysis (cHD) patients, and 36 healthy children (control group, CG). Lipid status, oxidative stress, and paraoxonase 1 (PON1) status were assessed. cIMT was measured by ultrasound, adjusted for age and sex, and presented as standard deviation scores (SDS). Children with CKD had disturbed lipid content, which was most pronounced in cHD children, with higher free cholesterol and triglycerides compared with healthy children. Oxidative stress was markedly increased (malodialdehyde [MDA, mu mol/L]: CRF 1.50 +/- 0.26, RT 1.55 +/- 0.40, cHD 1.77 +/- 0.34, CG 0.97 +/- 0.33, p lt 0.001) and antioxidative defense was compromised (superoxide dismutase [SOD, U/L]: CG 120 +/- 21, CRF 84 +/- 25, RT 93 +/- 12, cHD 119 +/- 37, p lt 0.001). Multiple linear regression analysis showed that a model that included disease duration, blood pressure, urea, lipid, and oxidative status parameters accounted for more than 90% of the variability of cIMT-SDS. Early atherosclerosis in CKD children is caused, at least in part, by dyslipidemia and oxidative stress. Monitoring of vessel wall changes, along with assessment of oxidative stress status and high density lipoprotein (HDL) functionality is necessary to ensure better therapeutic strategies for delaying atherosclerotic changes in their asymptomatic phase.en
dc.publisherSpringer, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsrestrictedAccess
dc.sourcePediatric Nephrology
dc.subjectOxidative stressen
dc.subjectHyperlipidemiaen
dc.subjectParaoxonaseen
dc.subjectIntima media thicknessen
dc.titleHyperlipidemia, oxidative stress, and intima media thickness in children with chronic kidney diseaseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПецо-Aнтић, Aмира; Јелић-Ивановић, Зорана; Спасић, Славица; Спасојевић-Калимановска, Весна; Костић, Мирјана; Васић, Драган; Вујовић, Aна; Корнић-Ристовски, Данијела; Котур-Стевуљевић, Јелена; Париповић, Душан; Стефановић, Aлександра;
dc.citation.volume28
dc.citation.issue2
dc.citation.spage295
dc.citation.epage303
dc.citation.other28(2): 295-303
dc.citation.rankM21
dc.identifier.wos000313431600015
dc.identifier.doi10.1007/s00467-012-2323-5
dc.identifier.pmid23117581
dc.identifier.scopus2-s2.0-84875843222
dc.identifier.rcubconv_2755
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record