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dc.creatorMilivojevic, M.
dc.creatorBošković, V.
dc.creatorAtanackovic, J.
dc.creatorMilicevic, S.
dc.creatorRažić, Slavica
dc.creatorKastratović-Kotlica, Biljana
dc.date.accessioned2019-09-02T11:35:07Z
dc.date.available2019-09-02T11:35:07Z
dc.date.issued2013
dc.identifier.issn0392-2936
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1950
dc.description.abstractThe objective of this study was to determine the potential of osteopontin (OPN) and OPN + CA125 (cancer antigen 125) combination in differential diagnosis of the ovarian cancers and non-malignant ovarian disease. Serum and plasma samples were obtained preoperatively from 79 women undergoing surgery for pelvic mass; 48 of them had ovarian carcinoma, and 31 had benign cyst. The samples were analyzed for the levels of OPN and CA 125 (using ELISA and CMIA methods) and then compared with the final pathologic results. The median plasma level of OPN in patients with benign and malignant cysts was 356.33 ng/ml and 865.15 ng/ml, respectively (p lt 0.001). Receiver operating characteristic (ROC) analysis for plasma OPN revealed the area under the curve (AUC) of 0.838. At the predefined specificity of 90%, OPN showed sensitivity of 62.5%, whereas the combination of OPN + CA125 reached 74.9% at the same specificity.en
dc.publisherI R O G Canada, Inc, Montreal
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Gynaecological Oncology
dc.subjectOvarian canceren
dc.subjectOsteopontinen
dc.subjectCA125en
dc.subjectTumor markersen
dc.titleEvaluation of osteopontin and CA125 in detection of epithelial ovarian carcinomaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМилицевиц, С.; Ражић, Славица; Кастратовић-Котлица, Биљана; Aтанацковиц, Ј.; Бошковић, В.; Миливојевиц, М.;
dc.citation.volume34
dc.citation.issue1
dc.citation.spage83
dc.citation.epage85
dc.citation.other34(1): 83-85
dc.citation.rankM23
dc.identifier.wos000314617700016
dc.identifier.pmid23590008
dc.identifier.scopus2-s2.0-84875046117
dc.identifier.rcubconv_2769
dc.type.versionpublishedVersion


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