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Economic evaluation of different screening alternatives for patients with clinically suspected acute deep vein thrombosis

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2013
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Authors
Bogavac-Stanojević, Nataša
Dopsaj, Violeta
Jelić-Ivanović, Zorana
Lakić, Dragana
Vasić, Dragan
Petrova, Guenka
Article (Published version)
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Abstract
Introduction: We examined the cost-effectiveness of the three different D-dimer measurements in the screening of DVT in models with and without calculation of pre-test probability (PTP) score. Moreover, we calculated the minimal cost in DVT detection. Material and methods: In the group of 192 patients with clinically suspected acute DVT, we examined the three different D-dimer measurements (Innovance D-dimer, Hemosil D-dimer HS and Vidas D-dimer Exclusion II) in combination with and without PTP assessment. Results: The diagnostic alternative employing Vidas D-dimer Exclusion II assay without and with PTP calculation gave lower incremental cost-effectiveness ratio (ICER) than the alternative employing Hemosil D-dimer HS assay (0.187 Euros vs. 0.998 Euros per one additional DVT positive patient selected for CUS in model without PTP assessment and 0.450 vs. 0.753 Euros per one DVT positive patient selected for CUS in model with PTP assessment). According to sensitivity analysis, the Hemos...il D-dimer HS assay was the most cost effective alternative when one patient was admitted to the vascular ambulance per day. Vidas D-dimer Exclusion II assay was the most cost effective alternative when more than one patient were admitted to the vascular ambulance per day. Cost minimisation analysis indicated that selection of patients according to PTP score followed by D-dimer analysis decreases the cost of DVT diagnosis. Conclusions: ICER analysis enables laboratories to choose optimal laboratory tests according to number of patients admitted to laboratory. Results support the feasibility of using PTP scoring and D-dimer measurement before CUS examination in DVT screening.

Keywords:
cost-effectiveness analysis / D dimer / deep vein thrombosis / pre-test probability score
Source:
Biochemia Medica, 2013, 23, 1, 96-106
Publisher:
  • Croatian Soc Medical Biochemists, Zagreb
Funding / projects:
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)

DOI: 10.11613/BM.2013.012

ISSN: 1330-0962

PubMed: 23457770

WoS: 000314728400013

Scopus: 2-s2.0-84873534695
[ Google Scholar ]
7
7
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1952
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Bogavac-Stanojević, Nataša
AU  - Dopsaj, Violeta
AU  - Jelić-Ivanović, Zorana
AU  - Lakić, Dragana
AU  - Vasić, Dragan
AU  - Petrova, Guenka
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1952
AB  - Introduction: We examined the cost-effectiveness of the three different D-dimer measurements in the screening of DVT in models with and without calculation of pre-test probability (PTP) score. Moreover, we calculated the minimal cost in DVT detection. Material and methods: In the group of 192 patients with clinically suspected acute DVT, we examined the three different D-dimer measurements (Innovance D-dimer, Hemosil D-dimer HS and Vidas D-dimer Exclusion II) in combination with and without PTP assessment. Results: The diagnostic alternative employing Vidas D-dimer Exclusion II assay without and with PTP calculation gave lower incremental cost-effectiveness ratio (ICER) than the alternative employing Hemosil D-dimer HS assay (0.187 Euros vs. 0.998 Euros per one additional DVT positive patient selected for CUS in model without PTP assessment and 0.450 vs. 0.753 Euros per one DVT positive patient selected for CUS in model with PTP assessment). According to sensitivity analysis, the Hemosil D-dimer HS assay was the most cost effective alternative when one patient was admitted to the vascular ambulance per day. Vidas D-dimer Exclusion II assay was the most cost effective alternative when more than one patient were admitted to the vascular ambulance per day. Cost minimisation analysis indicated that selection of patients according to PTP score followed by D-dimer analysis decreases the cost of DVT diagnosis. Conclusions: ICER analysis enables laboratories to choose optimal laboratory tests according to number of patients admitted to laboratory. Results support the feasibility of using PTP scoring and D-dimer measurement before CUS examination in DVT screening.
PB  - Croatian Soc Medical Biochemists, Zagreb
T2  - Biochemia Medica
T1  - Economic evaluation of different screening alternatives for patients with clinically suspected acute deep vein thrombosis
VL  - 23
IS  - 1
SP  - 96
EP  - 106
DO  - 10.11613/BM.2013.012
ER  - 
@article{
author = "Bogavac-Stanojević, Nataša and Dopsaj, Violeta and Jelić-Ivanović, Zorana and Lakić, Dragana and Vasić, Dragan and Petrova, Guenka",
year = "2013",
abstract = "Introduction: We examined the cost-effectiveness of the three different D-dimer measurements in the screening of DVT in models with and without calculation of pre-test probability (PTP) score. Moreover, we calculated the minimal cost in DVT detection. Material and methods: In the group of 192 patients with clinically suspected acute DVT, we examined the three different D-dimer measurements (Innovance D-dimer, Hemosil D-dimer HS and Vidas D-dimer Exclusion II) in combination with and without PTP assessment. Results: The diagnostic alternative employing Vidas D-dimer Exclusion II assay without and with PTP calculation gave lower incremental cost-effectiveness ratio (ICER) than the alternative employing Hemosil D-dimer HS assay (0.187 Euros vs. 0.998 Euros per one additional DVT positive patient selected for CUS in model without PTP assessment and 0.450 vs. 0.753 Euros per one DVT positive patient selected for CUS in model with PTP assessment). According to sensitivity analysis, the Hemosil D-dimer HS assay was the most cost effective alternative when one patient was admitted to the vascular ambulance per day. Vidas D-dimer Exclusion II assay was the most cost effective alternative when more than one patient were admitted to the vascular ambulance per day. Cost minimisation analysis indicated that selection of patients according to PTP score followed by D-dimer analysis decreases the cost of DVT diagnosis. Conclusions: ICER analysis enables laboratories to choose optimal laboratory tests according to number of patients admitted to laboratory. Results support the feasibility of using PTP scoring and D-dimer measurement before CUS examination in DVT screening.",
publisher = "Croatian Soc Medical Biochemists, Zagreb",
journal = "Biochemia Medica",
title = "Economic evaluation of different screening alternatives for patients with clinically suspected acute deep vein thrombosis",
volume = "23",
number = "1",
pages = "96-106",
doi = "10.11613/BM.2013.012"
}
Bogavac-Stanojević, N., Dopsaj, V., Jelić-Ivanović, Z., Lakić, D., Vasić, D.,& Petrova, G.. (2013). Economic evaluation of different screening alternatives for patients with clinically suspected acute deep vein thrombosis. in Biochemia Medica
Croatian Soc Medical Biochemists, Zagreb., 23(1), 96-106.
https://doi.org/10.11613/BM.2013.012
Bogavac-Stanojević N, Dopsaj V, Jelić-Ivanović Z, Lakić D, Vasić D, Petrova G. Economic evaluation of different screening alternatives for patients with clinically suspected acute deep vein thrombosis. in Biochemia Medica. 2013;23(1):96-106.
doi:10.11613/BM.2013.012 .
Bogavac-Stanojević, Nataša, Dopsaj, Violeta, Jelić-Ivanović, Zorana, Lakić, Dragana, Vasić, Dragan, Petrova, Guenka, "Economic evaluation of different screening alternatives for patients with clinically suspected acute deep vein thrombosis" in Biochemia Medica, 23, no. 1 (2013):96-106,
https://doi.org/10.11613/BM.2013.012 . .

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