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dc.creatorBogavac-Stanojević, Nataša
dc.creatorDopsaj, Violeta
dc.creatorJelić-Ivanović, Zorana
dc.creatorLakić, Dragana
dc.creatorVasić, Dragan
dc.creatorPetrova, Guenka
dc.date.accessioned2019-09-02T11:35:08Z
dc.date.available2019-09-02T11:35:08Z
dc.date.issued2013
dc.identifier.issn1330-0962
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1952
dc.description.abstractIntroduction: We examined the cost-effectiveness of the three different D-dimer measurements in the screening of DVT in models with and without calculation of pre-test probability (PTP) score. Moreover, we calculated the minimal cost in DVT detection. Material and methods: In the group of 192 patients with clinically suspected acute DVT, we examined the three different D-dimer measurements (Innovance D-dimer, Hemosil D-dimer HS and Vidas D-dimer Exclusion II) in combination with and without PTP assessment. Results: The diagnostic alternative employing Vidas D-dimer Exclusion II assay without and with PTP calculation gave lower incremental cost-effectiveness ratio (ICER) than the alternative employing Hemosil D-dimer HS assay (0.187 Euros vs. 0.998 Euros per one additional DVT positive patient selected for CUS in model without PTP assessment and 0.450 vs. 0.753 Euros per one DVT positive patient selected for CUS in model with PTP assessment). According to sensitivity analysis, the Hemosil D-dimer HS assay was the most cost effective alternative when one patient was admitted to the vascular ambulance per day. Vidas D-dimer Exclusion II assay was the most cost effective alternative when more than one patient were admitted to the vascular ambulance per day. Cost minimisation analysis indicated that selection of patients according to PTP score followed by D-dimer analysis decreases the cost of DVT diagnosis. Conclusions: ICER analysis enables laboratories to choose optimal laboratory tests according to number of patients admitted to laboratory. Results support the feasibility of using PTP scoring and D-dimer measurement before CUS examination in DVT screening.en
dc.publisherCroatian Soc Medical Biochemists, Zagreb
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.sourceBiochemia Medica
dc.subjectcost-effectiveness analysisen
dc.subjectD dimeren
dc.subjectdeep vein thrombosisen
dc.subjectpre-test probability scoreen
dc.titleEconomic evaluation of different screening alternatives for patients with clinically suspected acute deep vein thrombosisen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЛакић, Драгана; Петрова, Гуенка; Јелић-Ивановић, Зорана; Васић, Драган; Богавац-Станојевић, Наташа; Допсај, Виолета;
dc.citation.volume23
dc.citation.issue1
dc.citation.spage96
dc.citation.epage106
dc.citation.other23(1): 96-106
dc.citation.rankM21
dc.identifier.wos000314728400013
dc.identifier.doi10.11613/BM.2013.012
dc.identifier.pmid23457770
dc.identifier.scopus2-s2.0-84873534695
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/722/1950.pdf
dc.identifier.rcubconv_2772
dc.type.versionpublishedVersion


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