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dc.creatorLukić, Jovanka
dc.creatorStrahinić, Ivana
dc.creatorMilenković, Marina
dc.creatorGolić, Nataša
dc.creatorKojić, Milan
dc.creatorTopisirović, Ljubiša
dc.creatorBegović, Jelena
dc.date.accessioned2019-09-02T11:35:12Z
dc.date.available2019-09-02T11:35:12Z
dc.date.issued2013
dc.identifier.issn0099-2240
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1953
dc.description.abstractThe present study was carried out to test the colonic mucosal response of rats to oral supplementation with Lactobacillus fermentum BGHI14 and to correlate the tissue reaction to trinitrobenzenesulfonate (TNBS)-induced colitis with mucosal barrier alterations caused by bacterial ingestion. An immune cell-mediated reaction of healthy colonic tissue was noticed after bacterial feeding. After prolonged bacterial treatment, the observed reaction had retreated to normality, but the mRNA levels of proinflammatory cytokines interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) remained elevated. These data point to the chronic low-grade inflammation that could be caused by long-term probiotic consumption. Although no detrimental effects of bacterial pretreatment were noticed in colitic rats, at least in the acute state of disease, the results obtained in our study point to the necessity of reassessment of existing data on the safety of probiotic preparations. Additionally, probiotic effects in experimental colitis models might depend on time coordination of disease induction with treatment duration.en
dc.publisherAmer Soc Microbiology, Washington
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173019/RS//
dc.rightsopenAccess
dc.sourceApplied and Environmental Microbiology
dc.titleInteraction of Lactobacillus fermentum BGHI14 with Rat Colonic Mucosa: Implications for Colitis Inductionen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтрахинић, Ивана; Беговић, Јелена; Миленковић, Марина; Голић, Наташа; Лукић, Јованка; Којић, Милан; Тописировић, Љубиша;
dc.citation.volume79
dc.citation.issue18
dc.citation.spage5735
dc.citation.epage5744
dc.citation.other79(18): 5735-5744
dc.citation.rankM21
dc.identifier.wos000323421900036
dc.identifier.doi10.1128/AEM.01807-13
dc.identifier.pmid23851097
dc.identifier.scopus2-s2.0-84884274497
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/723/1951.pdf
dc.identifier.rcubconv_2895
dc.type.versionpublishedVersion


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