Moisturizing emulsion systems based on the novel long-chain alkyl polyglucoside emulsifier The contribution of thermoanalytical methods to the formulation development
Само за регистроване кориснике
2013
Аутори
Lukić, MilicaPantelić, Ivana
Daniels, Rolf
Mueller-Goymann, Christel
Savić, Miroslav
Savić, Snežana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Mesomorphic behavior of the novel long-chain alkyl polyglucoside emulsifier comprising arachidyl alcohol (C-20), behenyl alcohol (C-22), and arachidyl glucoside was investigated in order to determine the prevalent stabilization mechanism and moisturizing capacity of emulsion systems based on it. For this to be accomplished thermoanalytical methods (differential scanning calorimetry and thermogravimetric analysis) coupled with microscopy, rheological, X-ray diffraction methods and a short-term in vivo study of skin hydration level were performed. Obtained results have proved that C-20/C-22 alkyl polyglucoside mixed emulsifier is able to provide the synergism between the two main types of lamellar phases, the liquid-crystalline (L alpha), and the gel crystalline (L beta) one, building the emulsion systems of different stability and performance. Formation of lamellar structures influenced for more than one half of water within the system to be entrapped. Conducted investigation of hydrati...on potential in real-time conditions provided valuable information on the investigated emulsion vehicles' moisturizing potential as well as their contribution to the skin barrier improvement. Therefore, it could be expected that emulsions based on this alkyl polyglucoside emulsifier could influence the delivery of active ingredients of both the lipophilic and hydrophilic type. The employment of thermoanalytical methods in our work suggests the possibility for thermal methods to be used more frequently in the characterization of both the novel raw materials and the belonging emulsion systems.
Кључне речи:
Alkyl polyglucoside emulsifier / Moisturizing capacity / Emulsions / Thermal methodsИзвор:
Journal of Thermal Analysis and Calorimetry, 2013, 111, 3, 2045-2057Издавач:
- Springer, Dordrecht
Финансирање / пројекти:
- Развој микро- и наносистема као носача за лекове са антиинфламаторним деловањем и метода за њихову карактеризацију (RS-MESTD-Technological Development (TD or TR)-34031)
DOI: 10.1007/s10973-012-2263-0
ISSN: 1388-6150
WoS: 000315298800051
Scopus: 2-s2.0-84881434897
Институција/група
PharmacyTY - JOUR AU - Lukić, Milica AU - Pantelić, Ivana AU - Daniels, Rolf AU - Mueller-Goymann, Christel AU - Savić, Miroslav AU - Savić, Snežana PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1956 AB - Mesomorphic behavior of the novel long-chain alkyl polyglucoside emulsifier comprising arachidyl alcohol (C-20), behenyl alcohol (C-22), and arachidyl glucoside was investigated in order to determine the prevalent stabilization mechanism and moisturizing capacity of emulsion systems based on it. For this to be accomplished thermoanalytical methods (differential scanning calorimetry and thermogravimetric analysis) coupled with microscopy, rheological, X-ray diffraction methods and a short-term in vivo study of skin hydration level were performed. Obtained results have proved that C-20/C-22 alkyl polyglucoside mixed emulsifier is able to provide the synergism between the two main types of lamellar phases, the liquid-crystalline (L alpha), and the gel crystalline (L beta) one, building the emulsion systems of different stability and performance. Formation of lamellar structures influenced for more than one half of water within the system to be entrapped. Conducted investigation of hydration potential in real-time conditions provided valuable information on the investigated emulsion vehicles' moisturizing potential as well as their contribution to the skin barrier improvement. Therefore, it could be expected that emulsions based on this alkyl polyglucoside emulsifier could influence the delivery of active ingredients of both the lipophilic and hydrophilic type. The employment of thermoanalytical methods in our work suggests the possibility for thermal methods to be used more frequently in the characterization of both the novel raw materials and the belonging emulsion systems. PB - Springer, Dordrecht T2 - Journal of Thermal Analysis and Calorimetry T1 - Moisturizing emulsion systems based on the novel long-chain alkyl polyglucoside emulsifier The contribution of thermoanalytical methods to the formulation development VL - 111 IS - 3 SP - 2045 EP - 2057 DO - 10.1007/s10973-012-2263-0 ER -
@article{ author = "Lukić, Milica and Pantelić, Ivana and Daniels, Rolf and Mueller-Goymann, Christel and Savić, Miroslav and Savić, Snežana", year = "2013", abstract = "Mesomorphic behavior of the novel long-chain alkyl polyglucoside emulsifier comprising arachidyl alcohol (C-20), behenyl alcohol (C-22), and arachidyl glucoside was investigated in order to determine the prevalent stabilization mechanism and moisturizing capacity of emulsion systems based on it. For this to be accomplished thermoanalytical methods (differential scanning calorimetry and thermogravimetric analysis) coupled with microscopy, rheological, X-ray diffraction methods and a short-term in vivo study of skin hydration level were performed. Obtained results have proved that C-20/C-22 alkyl polyglucoside mixed emulsifier is able to provide the synergism between the two main types of lamellar phases, the liquid-crystalline (L alpha), and the gel crystalline (L beta) one, building the emulsion systems of different stability and performance. Formation of lamellar structures influenced for more than one half of water within the system to be entrapped. Conducted investigation of hydration potential in real-time conditions provided valuable information on the investigated emulsion vehicles' moisturizing potential as well as their contribution to the skin barrier improvement. Therefore, it could be expected that emulsions based on this alkyl polyglucoside emulsifier could influence the delivery of active ingredients of both the lipophilic and hydrophilic type. The employment of thermoanalytical methods in our work suggests the possibility for thermal methods to be used more frequently in the characterization of both the novel raw materials and the belonging emulsion systems.", publisher = "Springer, Dordrecht", journal = "Journal of Thermal Analysis and Calorimetry", title = "Moisturizing emulsion systems based on the novel long-chain alkyl polyglucoside emulsifier The contribution of thermoanalytical methods to the formulation development", volume = "111", number = "3", pages = "2045-2057", doi = "10.1007/s10973-012-2263-0" }
Lukić, M., Pantelić, I., Daniels, R., Mueller-Goymann, C., Savić, M.,& Savić, S.. (2013). Moisturizing emulsion systems based on the novel long-chain alkyl polyglucoside emulsifier The contribution of thermoanalytical methods to the formulation development. in Journal of Thermal Analysis and Calorimetry Springer, Dordrecht., 111(3), 2045-2057. https://doi.org/10.1007/s10973-012-2263-0
Lukić M, Pantelić I, Daniels R, Mueller-Goymann C, Savić M, Savić S. Moisturizing emulsion systems based on the novel long-chain alkyl polyglucoside emulsifier The contribution of thermoanalytical methods to the formulation development. in Journal of Thermal Analysis and Calorimetry. 2013;111(3):2045-2057. doi:10.1007/s10973-012-2263-0 .
Lukić, Milica, Pantelić, Ivana, Daniels, Rolf, Mueller-Goymann, Christel, Savić, Miroslav, Savić, Snežana, "Moisturizing emulsion systems based on the novel long-chain alkyl polyglucoside emulsifier The contribution of thermoanalytical methods to the formulation development" in Journal of Thermal Analysis and Calorimetry, 111, no. 3 (2013):2045-2057, https://doi.org/10.1007/s10973-012-2263-0 . .