Midazolam impairs acquisition and retrieval, but not consolidation of reference memory in the Morris water maze
Само за регистроване кориснике
2013
Аутори
Timić, TamaraJoksimović, Srđan
Milić, Marija
Divljaković, Jovana
Batinić, Bojan
Savić, Miroslav
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Amnesia is one of the most discussed properties of the benzodiazepine class of drugs. The effects of benzodiazepines on human memory are usually anterograde, while changes in retrograde memory functions were seldom reported. Such inconsistent findings have prompted numerous animal studies investigating the influences of these positive modulators of inhibitory neurotransmission on different stages of memory. Among the benzodiazepines, memory effects of midazolam are of special interest due to its many and varied clinical applications. The present Morris water maze study in adult male Wistar rats was performed in three experiments in which midazolam was administered at doses of 0.5, 1 and 2 mg/kg intraperitoneally, before or immediately after each of five daily learning sessions, with two trials in a session, as well as before the probe test. Midazolam impaired acquisition and subsequent retention of spatial learning of the position of the hidden platform even at a pre-training dose of 0....5 mg/kg. This low dose was not associated with impairment of the procedural component of learning, manifested by increased time spent in the periphery of the pool. The lack of midazolam effect on consolidation has not been confounded by the observed below-chance performance of the control group since our additional experiment using diazepam also administered immediately after each of five learning sessions has revealed a similar pattern of results. Finally, midazolam administered before the probe test impaired retrieval of reference memory at all tested doses. Hence, induction of retrograde, besides anterograde amnesia should be kept in mind as a possibility when midazolam is used in clinical settings.
Кључне речи:
Benzodiazepines / Amnesia / Diazepam / RatsИзвор:
Behavioural Brain Research, 2013, 241, 198-205Издавач:
- Elsevier Science BV, Amsterdam
Финансирање / пројекти:
- Бихејвиорални ефекти понављане примене новосинтетисаних супстанци селективних за поједине подтипове бензодиазепинског места везивања ГАБА А рецептора: поређење са стандардним психофармаколошким лековима (RS-MESTD-Basic Research (BR or ON)-175076)
DOI: 10.1016/j.bbr.2012.12.014
ISSN: 0166-4328
PubMed: 23261388
WoS: 000315308700026
Scopus: 2-s2.0-84872009406
Институција/група
PharmacyTY - JOUR AU - Timić, Tamara AU - Joksimović, Srđan AU - Milić, Marija AU - Divljaković, Jovana AU - Batinić, Bojan AU - Savić, Miroslav PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1957 AB - Amnesia is one of the most discussed properties of the benzodiazepine class of drugs. The effects of benzodiazepines on human memory are usually anterograde, while changes in retrograde memory functions were seldom reported. Such inconsistent findings have prompted numerous animal studies investigating the influences of these positive modulators of inhibitory neurotransmission on different stages of memory. Among the benzodiazepines, memory effects of midazolam are of special interest due to its many and varied clinical applications. The present Morris water maze study in adult male Wistar rats was performed in three experiments in which midazolam was administered at doses of 0.5, 1 and 2 mg/kg intraperitoneally, before or immediately after each of five daily learning sessions, with two trials in a session, as well as before the probe test. Midazolam impaired acquisition and subsequent retention of spatial learning of the position of the hidden platform even at a pre-training dose of 0.5 mg/kg. This low dose was not associated with impairment of the procedural component of learning, manifested by increased time spent in the periphery of the pool. The lack of midazolam effect on consolidation has not been confounded by the observed below-chance performance of the control group since our additional experiment using diazepam also administered immediately after each of five learning sessions has revealed a similar pattern of results. Finally, midazolam administered before the probe test impaired retrieval of reference memory at all tested doses. Hence, induction of retrograde, besides anterograde amnesia should be kept in mind as a possibility when midazolam is used in clinical settings. PB - Elsevier Science BV, Amsterdam T2 - Behavioural Brain Research T1 - Midazolam impairs acquisition and retrieval, but not consolidation of reference memory in the Morris water maze VL - 241 SP - 198 EP - 205 DO - 10.1016/j.bbr.2012.12.014 ER -
@article{ author = "Timić, Tamara and Joksimović, Srđan and Milić, Marija and Divljaković, Jovana and Batinić, Bojan and Savić, Miroslav", year = "2013", abstract = "Amnesia is one of the most discussed properties of the benzodiazepine class of drugs. The effects of benzodiazepines on human memory are usually anterograde, while changes in retrograde memory functions were seldom reported. Such inconsistent findings have prompted numerous animal studies investigating the influences of these positive modulators of inhibitory neurotransmission on different stages of memory. Among the benzodiazepines, memory effects of midazolam are of special interest due to its many and varied clinical applications. The present Morris water maze study in adult male Wistar rats was performed in three experiments in which midazolam was administered at doses of 0.5, 1 and 2 mg/kg intraperitoneally, before or immediately after each of five daily learning sessions, with two trials in a session, as well as before the probe test. Midazolam impaired acquisition and subsequent retention of spatial learning of the position of the hidden platform even at a pre-training dose of 0.5 mg/kg. This low dose was not associated with impairment of the procedural component of learning, manifested by increased time spent in the periphery of the pool. The lack of midazolam effect on consolidation has not been confounded by the observed below-chance performance of the control group since our additional experiment using diazepam also administered immediately after each of five learning sessions has revealed a similar pattern of results. Finally, midazolam administered before the probe test impaired retrieval of reference memory at all tested doses. Hence, induction of retrograde, besides anterograde amnesia should be kept in mind as a possibility when midazolam is used in clinical settings.", publisher = "Elsevier Science BV, Amsterdam", journal = "Behavioural Brain Research", title = "Midazolam impairs acquisition and retrieval, but not consolidation of reference memory in the Morris water maze", volume = "241", pages = "198-205", doi = "10.1016/j.bbr.2012.12.014" }
Timić, T., Joksimović, S., Milić, M., Divljaković, J., Batinić, B.,& Savić, M.. (2013). Midazolam impairs acquisition and retrieval, but not consolidation of reference memory in the Morris water maze. in Behavioural Brain Research Elsevier Science BV, Amsterdam., 241, 198-205. https://doi.org/10.1016/j.bbr.2012.12.014
Timić T, Joksimović S, Milić M, Divljaković J, Batinić B, Savić M. Midazolam impairs acquisition and retrieval, but not consolidation of reference memory in the Morris water maze. in Behavioural Brain Research. 2013;241:198-205. doi:10.1016/j.bbr.2012.12.014 .
Timić, Tamara, Joksimović, Srđan, Milić, Marija, Divljaković, Jovana, Batinić, Bojan, Savić, Miroslav, "Midazolam impairs acquisition and retrieval, but not consolidation of reference memory in the Morris water maze" in Behavioural Brain Research, 241 (2013):198-205, https://doi.org/10.1016/j.bbr.2012.12.014 . .