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Cinnamic Acid Derivatives Induce Cell Cycle Arrest in Carcinoma Cell Lines

rcub.bitstream.locked
2013
Authors
Sova, Matej
Žižak, Željko
Antić-Stanković, Jelena
Prijatelj, Matevz
Turk, Samo
Juranić, Zorica
Mlinarić-Rascan, Irena
Gobec, Stanislav
Article (Published version)
Metadata
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Abstract
Cinnamic acid derivatives can be found in plant material, and they possess a remarkable variety of biological effects. In the present study, we have investigated the cytotoxic effects of representative cinnamic acid esters and amides. The cytotoxicity was determined by MTT test on human cervix adenocarcinoma (HeLa), myelogenous leukemia (K562), malignant melanoma (Fem-x), and estrogen-receptor-positive breast cancer (MCF-7) cells, versus peripheral blood mononuclear cells (PBMCs) without or with the addition of the plant lectin phytohemaglutinin (PHA). The compounds tested showed significant cytotoxicity (IC(50)s between 42 and 166 mu M) and furthermore selectivity of these cytotoxic effects on the malignant cell lines versus the PBMCs was also seen, especially when electron-withdrawing groups, such as a cyano group (compound 5), were present on the aromatic rings of the alcohol or amine parts of the cinnamic acid derivatives. The additional study on cell cycle phase distribution indic...ated that novel cinnamic acid derivatives inhibit cell growth by induction of cell death. Thus, cinnamic acids derivatives represent important lead compounds for further development of antineoplastic agents.

Keywords:
Cytotoxicity / cinnamates / anticancer drug discovery / antineoplastic drug
Source:
Medicinal Chemistry, 2013, 9, 5, 633-641
Publisher:
  • Bentham Science Publ Ltd, Sharjah
Funding / projects:
  • Ministry of Higher Education, Science and Technology of the Republic of Slovenia

DOI: 10.2174/1573406411309050002

ISSN: 1573-4064

PubMed: 23140579

WoS: 000320326200001

Scopus: 2-s2.0-84883369542
[ Google Scholar ]
19
16
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/1962
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Sova, Matej
AU  - Žižak, Željko
AU  - Antić-Stanković, Jelena
AU  - Prijatelj, Matevz
AU  - Turk, Samo
AU  - Juranić, Zorica
AU  - Mlinarić-Rascan, Irena
AU  - Gobec, Stanislav
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1962
AB  - Cinnamic acid derivatives can be found in plant material, and they possess a remarkable variety of biological effects. In the present study, we have investigated the cytotoxic effects of representative cinnamic acid esters and amides. The cytotoxicity was determined by MTT test on human cervix adenocarcinoma (HeLa), myelogenous leukemia (K562), malignant melanoma (Fem-x), and estrogen-receptor-positive breast cancer (MCF-7) cells, versus peripheral blood mononuclear cells (PBMCs) without or with the addition of the plant lectin phytohemaglutinin (PHA). The compounds tested showed significant cytotoxicity (IC(50)s between 42 and 166 mu M) and furthermore selectivity of these cytotoxic effects on the malignant cell lines versus the PBMCs was also seen, especially when electron-withdrawing groups, such as a cyano group (compound 5), were present on the aromatic rings of the alcohol or amine parts of the cinnamic acid derivatives. The additional study on cell cycle phase distribution indicated that novel cinnamic acid derivatives inhibit cell growth by induction of cell death. Thus, cinnamic acids derivatives represent important lead compounds for further development of antineoplastic agents.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Medicinal Chemistry
T1  - Cinnamic Acid Derivatives Induce Cell Cycle Arrest in Carcinoma Cell Lines
VL  - 9
IS  - 5
SP  - 633
EP  - 641
DO  - 10.2174/1573406411309050002
ER  - 
@article{
author = "Sova, Matej and Žižak, Željko and Antić-Stanković, Jelena and Prijatelj, Matevz and Turk, Samo and Juranić, Zorica and Mlinarić-Rascan, Irena and Gobec, Stanislav",
year = "2013",
abstract = "Cinnamic acid derivatives can be found in plant material, and they possess a remarkable variety of biological effects. In the present study, we have investigated the cytotoxic effects of representative cinnamic acid esters and amides. The cytotoxicity was determined by MTT test on human cervix adenocarcinoma (HeLa), myelogenous leukemia (K562), malignant melanoma (Fem-x), and estrogen-receptor-positive breast cancer (MCF-7) cells, versus peripheral blood mononuclear cells (PBMCs) without or with the addition of the plant lectin phytohemaglutinin (PHA). The compounds tested showed significant cytotoxicity (IC(50)s between 42 and 166 mu M) and furthermore selectivity of these cytotoxic effects on the malignant cell lines versus the PBMCs was also seen, especially when electron-withdrawing groups, such as a cyano group (compound 5), were present on the aromatic rings of the alcohol or amine parts of the cinnamic acid derivatives. The additional study on cell cycle phase distribution indicated that novel cinnamic acid derivatives inhibit cell growth by induction of cell death. Thus, cinnamic acids derivatives represent important lead compounds for further development of antineoplastic agents.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Medicinal Chemistry",
title = "Cinnamic Acid Derivatives Induce Cell Cycle Arrest in Carcinoma Cell Lines",
volume = "9",
number = "5",
pages = "633-641",
doi = "10.2174/1573406411309050002"
}
Sova, M., Žižak, Ž., Antić-Stanković, J., Prijatelj, M., Turk, S., Juranić, Z., Mlinarić-Rascan, I.,& Gobec, S.. (2013). Cinnamic Acid Derivatives Induce Cell Cycle Arrest in Carcinoma Cell Lines. in Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 9(5), 633-641.
https://doi.org/10.2174/1573406411309050002
Sova M, Žižak Ž, Antić-Stanković J, Prijatelj M, Turk S, Juranić Z, Mlinarić-Rascan I, Gobec S. Cinnamic Acid Derivatives Induce Cell Cycle Arrest in Carcinoma Cell Lines. in Medicinal Chemistry. 2013;9(5):633-641.
doi:10.2174/1573406411309050002 .
Sova, Matej, Žižak, Željko, Antić-Stanković, Jelena, Prijatelj, Matevz, Turk, Samo, Juranić, Zorica, Mlinarić-Rascan, Irena, Gobec, Stanislav, "Cinnamic Acid Derivatives Induce Cell Cycle Arrest in Carcinoma Cell Lines" in Medicinal Chemistry, 9, no. 5 (2013):633-641,
https://doi.org/10.2174/1573406411309050002 . .

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