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Synthesis, characterization, DFT calculations and biological activity of derivatives of 3-acetylpyridine and the zinc(II) complex with the condensation product of 3-acetylpyridine and semicarbazide

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2013
Authors
Cobeljić, Božidar
Pevec, Andrej
Turel, Iztok
Swart, Marcel
Mitić, Dragana
Milenković, Marina
Marković, Ivanka
Jovanović, Maja
Sladić, Dušan
Jeremić, Marko
Anđelković, Katarina
Article (Published version)
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Abstract
A Schiff base of 3-acetylpyridine with semicarbazide as well as the corresponding tetrahedral Zn(II) complex were synthesized and characterized by X-ray crystal structure analysis and spectroscopic methods. It is interesting to note that the ligand coordinated as a monodentate although there are several donor atoms in it. Computational studies showed that such structure is more stable than the hypothetical structure with one ligand bound as a bidentate. The complex exibited moderate antibacterial, antifungal and cytotoxic activities while the ligand was mostly inactive. The complex strongly induced formation of reactive oxygen species in tumor cell lines. It also influenced cell cycle progression in tumor cell lines, and induced autophagy. The latter effect is, at least in part, a protective one.
Keywords:
Zn(II) complex / Schiff base / DFT calculations / Biological activity
Source:
Inorganica Chimica Acta, 2013, 404, 5-12
Publisher:
  • Elsevier Science Sa, Lausanne
Projects:
  • Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-172055)
  • ICREA

DOI: 10.1016/j.ica.2013.04.017

ISSN: 0020-1693

WoS: 000320651900002

Scopus: 2-s2.0-84878219485
[ Google Scholar ]
13
11
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1964
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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