Synthesis, characterization, DFT calculations and biological activity of derivatives of 3-acetylpyridine and the zinc(II) complex with the condensation product of 3-acetylpyridine and semicarbazide
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2013
Authors
Cobeljić, Božidar
Pevec, Andrej
Turel, Iztok

Swart, Marcel

Mitić, Dragana

Milenković, Marina

Marković, Ivanka

Jovanović, Maja
Sladić, Dušan

Jeremić, Marko

Anđelković, Katarina

Article (Published version)

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Show full item recordAbstract
A Schiff base of 3-acetylpyridine with semicarbazide as well as the corresponding tetrahedral Zn(II) complex were synthesized and characterized by X-ray crystal structure analysis and spectroscopic methods. It is interesting to note that the ligand coordinated as a monodentate although there are several donor atoms in it. Computational studies showed that such structure is more stable than the hypothetical structure with one ligand bound as a bidentate. The complex exibited moderate antibacterial, antifungal and cytotoxic activities while the ligand was mostly inactive. The complex strongly induced formation of reactive oxygen species in tumor cell lines. It also influenced cell cycle progression in tumor cell lines, and induced autophagy. The latter effect is, at least in part, a protective one.
Keywords:
Zn(II) complex / Schiff base / DFT calculations / Biological activitySource:
Inorganica Chimica Acta, 2013, 404, 5-12Publisher:
- Elsevier Science Sa, Lausanne
Projects:
- Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-172055)
- ICREA
DOI: 10.1016/j.ica.2013.04.017
ISSN: 0020-1693