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dc.creatorCobeljić, Božidar
dc.creatorPevec, Andrej
dc.creatorTurel, Iztok
dc.creatorSwart, Marcel
dc.creatorMitić, Dragana
dc.creatorMilenković, Marina
dc.creatorMarković, Ivanka
dc.creatorJovanović, Maja
dc.creatorSladić, Dušan
dc.creatorJeremić, Marko
dc.creatorAnđelković, Katarina
dc.date.accessioned2019-09-02T11:35:29Z
dc.date.available2019-09-02T11:35:29Z
dc.date.issued2013
dc.identifier.issn0020-1693
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/1964
dc.description.abstractA Schiff base of 3-acetylpyridine with semicarbazide as well as the corresponding tetrahedral Zn(II) complex were synthesized and characterized by X-ray crystal structure analysis and spectroscopic methods. It is interesting to note that the ligand coordinated as a monodentate although there are several donor atoms in it. Computational studies showed that such structure is more stable than the hypothetical structure with one ligand bound as a bidentate. The complex exibited moderate antibacterial, antifungal and cytotoxic activities while the ligand was mostly inactive. The complex strongly induced formation of reactive oxygen species in tumor cell lines. It also influenced cell cycle progression in tumor cell lines, and induced autophagy. The latter effect is, at least in part, a protective one.en
dc.publisherElsevier Science Sa, Lausanne
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationICREA
dc.rightsrestrictedAccess
dc.sourceInorganica Chimica Acta
dc.subjectZn(II) complexen
dc.subjectSchiff baseen
dc.subjectDFT calculationsen
dc.subjectBiological activityen
dc.titleSynthesis, characterization, DFT calculations and biological activity of derivatives of 3-acetylpyridine and the zinc(II) complex with the condensation product of 3-acetylpyridine and semicarbazideen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТурел, Изток; Марковић, Иванка; Сладић, Душан; Јовановић, Маја; Цобељић, Божидар; Сwарт, Марцел; Јеремић, Марко; Миленковић, Марина; Певец, Aндреј; Aнделковић, Катарина; Митић, Драгана;
dc.citation.volume404
dc.citation.spage5
dc.citation.epage12
dc.citation.other404: 5-12
dc.citation.rankM22
dc.identifier.wos000320651900002
dc.identifier.doi10.1016/j.ica.2013.04.017
dc.identifier.scopus2-s2.0-84878219485
dc.type.versionpublishedVersion


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