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dc.creatorVučinić, Slavica
dc.creatorZlatković, Milica
dc.creatorAntonijević, Biljana
dc.creatorĆurčić, Marijana
dc.creatorBošković, Bogdan
dc.date.accessioned2019-09-02T11:35:30Z
dc.date.available2019-09-02T11:35:30Z
dc.date.issued2013
dc.identifier.issn0004-1254
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1966
dc.description.abstractDespite improvements to intensive care management and specific pharmacological treatments (atropine, oxime, diazepam), the mortality associated with organophosphate (OP) poisoning has not substantially decreased. The objective of this examination was to describe the role of fresh frozen plasma (FFP) in acute OP poisoning. After a deliberate ingestion of malathion, a 55-year-old male suffering from miosis, somnolence, bradycardia, muscular fasciculations, rales on auscultation, respiratory insufficiency, as well as from an inhibition of red blood cell acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BuChE), was admitted to hospital. Malathion was confirmed in a concentration of 18.01 mg L-1. Apart from supportive measures (including mechanical ventilation for four days), antidotal treatment with atropine, oxime - pralidoxime methylsulphate (Contrathion (R)), and diazepam was administered, along with FFP. The potentially beneficial effects of FFP therapy included a prompt increase of BuChE activity (from 926 IU L-1 to 3277 IU L-1; reference range from 7000 IU L-1 to 19000 IU L-1) and a reduction in the malathion concentration, followed by clinical recovery. Due to BuChE replacement, albumin content, and volume restitution, FFP treatment may be used as an alternative approach in patients with acute OP poisoning, especially when oximes are not available.en
dc.publisherInst Medical Research & Occupational Health, Zagreb
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/176018/RS//
dc.rightsopenAccess
dc.sourceArhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
dc.subjectacetylcholinesterasesen
dc.subjectalbuminen
dc.subjectbutyrylcholinesteraseen
dc.subjectmalathionen
dc.subjectoximesen
dc.titleFresh frozen plasma as a successful antidotal supplement in acute organophosphate poisoningen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБошковић, Богдан; Ћурчић, Маријана; Златковић, Милица; Вучинић, Славица; Aнтонијевић, Биљана;
dc.citation.volume64
dc.citation.issue2
dc.citation.spage273
dc.citation.epage277
dc.citation.other64(2): 273-277
dc.citation.rankM23
dc.identifier.wos000321168600010
dc.identifier.doi10.2478/10004-1254-64-2013-2378
dc.identifier.pmid23819936
dc.identifier.scopus2-s2.0-84881119418
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/736/1964.pdf
dc.identifier.rcubconv_2871
dc.type.versionpublishedVersion


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