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dc.creatorČalija, Bojan
dc.creatorCekić, Nebojša
dc.creatorSavić, Snežana
dc.creatorDaniels, Rolf
dc.creatorMarković, Bojan
dc.creatorMilić, Jela
dc.date.accessioned2019-09-02T11:35:36Z
dc.date.available2019-09-02T11:35:36Z
dc.date.issued2013
dc.identifier.issn0927-7765
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1969
dc.description.abstractThe primary objective of this study was to investigate the influence of the oligochitosan-Eudragit (R) L100-55 polyelectrolyte complex (OCH-EL PEC) on the pH-sensitivity of Eudragit (R) L100-55-treated alginate-oligochitosan microparticles. In order to achieve this, three types of naproxen-loaded microparticles were prepared under mild and environmentally friendly conditions using a custom made device with coaxial air flow: Ca-alginate (Ca-ALG), alginate-oligochitosan (ALG-OCH) and alginate-oligochitosan-Eudragit (R) L100-55 (ALG-OCH-EL) microparticles. After drying, the microparticles were subjected to microscopic analysis, and physicochemical and biopharmaceutical characterization. The non-covalent interaction between OCH and EL and the formation of OCH-EL PEC during the preparation procedure of the particles were verified by thermal and FT-IR analysis. The obtained particles exhibited acceptable sphericity and surface roughness due to the presence of the drug crystals (Ca-ALG particles) and OCH-EL PEC (ALG-OCH-EL particles). It was found that reinforcement of the ALG-OCH particles with OCH-EL PEC had no significant effect on the relatively high encapsulation efficiencies (>74.4%). The results of drug release studies confirmed the ability of ALG-OCH PEC to sustain drug release at pH 6.8 and 7.4. However, this PEC showed enhanced sensitivity to an acidic environment and to simulated intestinal fluid (pH 6.8) after prior exposure to an acidic medium. Additional treatment of ALG-OCH particles with EL and formation of "sandwich" ALG-OCH-EL PEC was essential not only to improve stability and decrease drug release in acidic medium, but also to achieve sustained release after the pH of dissolution medium was raised to 6.8. The obtained results suggested that ALG-OCH-EL microparticles have promising potential as pH-sensitive multiparticulate drug carriers for oral delivery of NSAIDs.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.rightsrestrictedAccess
dc.sourceColloids and Surfaces B: Biointerfaces
dc.subjectMicroparticlesen
dc.subjectOligochitosanen
dc.subjectSodium alginateen
dc.subjectEudragit (R) L100-55en
dc.subjectPolyelectrolyte complexen
dc.subjectpH-sensitivityen
dc.titlepH-sensitive microparticles for oral drug delivery based on alginate/oligochitosan/Eudragit (R) L100-55 "sandwich" polyelectrolyte complexen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДаниелс, Ролф; Цекић, Небојша; Савић, Снежана; Чалија, Бојан; Милић, Јела; Марковић, Бојан;
dc.citation.volume110
dc.citation.spage395
dc.citation.epage402
dc.citation.other110: 395-402
dc.citation.rankM21
dc.identifier.wos000321940200053
dc.identifier.doi10.1016/j.colsurfb.2013.05.016
dc.identifier.pmid23751419
dc.identifier.scopus2-s2.0-84878968644
dc.identifier.rcubconv_2876
dc.type.versionpublishedVersion


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