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dc.creatorSavić, Ivana
dc.creatorNikolić, Katarina
dc.creatorNikolić, Goran
dc.creatorSavić, Ivan
dc.creatorAgbaba, Danica
dc.creatorCakić, Milorad
dc.date.accessioned2019-09-02T11:35:36Z
dc.date.available2019-09-02T11:35:36Z
dc.date.issued2013
dc.identifier.issn0363-9045
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1970
dc.description.abstractNew formulation for treatment a copper deficiency in human organism was developed and optimized by application of mathematical modeling. This formulation contained copper (II) complex with polysaccharide pullulan, as active substance. The binder concentration [polyvinyl pyrrolidone (PVP %)], the disintegrant concentration (corn starch %) and the resistance to crushing (hardness) were taken as independent variables. In vitro measured drug release characteristics of the tablets at pH 1.20 and 7.56 were studied as response variables. Initially, the created full factorial 2(3) model showed that the resistance to crushing has the most significant effect on copper (II) complex release from the formulation. Optimal tablet formulation F2, with lower Hardness (50 N), lower Starch (20.0%) and higher PVP (2.7%) concentrations, is selected using the partial least squares (PLS) regression modeling. The selected formulation F2 has expressed the best drug release profile at both pH (98.66% pH = 1.20; 93.35% pH = 7.56), and the lowest variation of tablets weight. The presented theoretical approach and created PLS model can be readily applied in future copper complexes studies and formulation design.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34012/RS//
dc.rightsrestrictedAccess
dc.sourceDrug Development and Industrial Pharmacy
dc.subjectCopperen
dc.subjectfull factorialen
dc.subjectexperimental designen
dc.subjectpartial least squaresen
dc.titleApplication of mathematical modeling for the development and optimization formulation with bioactive copper complexen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНиколић, Катарина; Цакић, Милорад; Aгбаба, Даница; Савић, Ивана М.; Савић, Иван; Николић, Горан;
dc.citation.volume39
dc.citation.issue7
dc.citation.spage1084
dc.citation.epage1090
dc.citation.other39(7): 1084-1090
dc.citation.rankM22
dc.identifier.wos000319986900018
dc.identifier.doi10.3109/03639045.2012.707208
dc.identifier.pmid22871119
dc.identifier.scopus2-s2.0-84878892367
dc.identifier.rcubconv_2862
dc.type.versionpublishedVersion


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