Clinical Application Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 as Indicators of Inflammation Persistence and Acute Kidney Injury in Children with Urinary Tract Infection

2013
Authors
Petrović, StanislavaBogavac-Stanojević, Nataša

Peco-Antić, Amira
Ivanišević, Ivana
Kotur-Stevuljević, Jelena

Paripović, Dušan

Sopić, Miron

Jelić-Ivanović, Zorana

Article (Published version)
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Background. The aim of this study was to examine the novel renal biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) to assist pediatricians in the assessment of longer duration of inflammation and acute kidney injury (AKI) development during urinary tract infection (UTI). Methods. The patients enrolled in the study comprised 50 children (mean age was 6 months) with UTI. NGAL in serum and urine (sNGAL and uNGAL, resp.) and KIM-1 in urine were measured by enzyme-linked immunosorbent assays. Results. uNGAL levels in subjects with longer duration of inflammation were higher (115.37 ng/mL) than uNGAL levels in subjects with shorter duration of inflammation (67.87 ng/mL, P = 0.022). Difference in sNGAL and KIM-1 levels was not significant (P = 0.155 and P = 0.198, resp.). Significant difference was seen in KIM-1 excretion among groups with and without AKI (P = 0.038). KIM-1 was not able to discriminate between subjects with and without AKI (area... under the curves (AUC) = 0.620, P = 0.175). Conclusions. uNGAL cannot be used for screening of the duration of inflammation during UTI. Accuracy of KIM-1 in screening of AKI development in children with UTI is low. We suggest larger studies to check the negative predictive value of KIM-1 for the development of AKI.
Source:
Biomed Research International, 2013Publisher:
- Hindawi Publishing Corporation, New York
Funding / projects:
DOI: 10.1155/2013/947157
ISSN: 2314-6133
PubMed: 23936859
WoS: 000322237800001
Scopus: 2-s2.0-84880908217
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PharmacyTY - JOUR AU - Petrović, Stanislava AU - Bogavac-Stanojević, Nataša AU - Peco-Antić, Amira AU - Ivanišević, Ivana AU - Kotur-Stevuljević, Jelena AU - Paripović, Dušan AU - Sopić, Miron AU - Jelić-Ivanović, Zorana PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1971 AB - Background. The aim of this study was to examine the novel renal biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) to assist pediatricians in the assessment of longer duration of inflammation and acute kidney injury (AKI) development during urinary tract infection (UTI). Methods. The patients enrolled in the study comprised 50 children (mean age was 6 months) with UTI. NGAL in serum and urine (sNGAL and uNGAL, resp.) and KIM-1 in urine were measured by enzyme-linked immunosorbent assays. Results. uNGAL levels in subjects with longer duration of inflammation were higher (115.37 ng/mL) than uNGAL levels in subjects with shorter duration of inflammation (67.87 ng/mL, P = 0.022). Difference in sNGAL and KIM-1 levels was not significant (P = 0.155 and P = 0.198, resp.). Significant difference was seen in KIM-1 excretion among groups with and without AKI (P = 0.038). KIM-1 was not able to discriminate between subjects with and without AKI (area under the curves (AUC) = 0.620, P = 0.175). Conclusions. uNGAL cannot be used for screening of the duration of inflammation during UTI. Accuracy of KIM-1 in screening of AKI development in children with UTI is low. We suggest larger studies to check the negative predictive value of KIM-1 for the development of AKI. PB - Hindawi Publishing Corporation, New York T2 - Biomed Research International T1 - Clinical Application Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 as Indicators of Inflammation Persistence and Acute Kidney Injury in Children with Urinary Tract Infection DO - 10.1155/2013/947157 ER -
@article{ author = "Petrović, Stanislava and Bogavac-Stanojević, Nataša and Peco-Antić, Amira and Ivanišević, Ivana and Kotur-Stevuljević, Jelena and Paripović, Dušan and Sopić, Miron and Jelić-Ivanović, Zorana", year = "2013", abstract = "Background. The aim of this study was to examine the novel renal biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) to assist pediatricians in the assessment of longer duration of inflammation and acute kidney injury (AKI) development during urinary tract infection (UTI). Methods. The patients enrolled in the study comprised 50 children (mean age was 6 months) with UTI. NGAL in serum and urine (sNGAL and uNGAL, resp.) and KIM-1 in urine were measured by enzyme-linked immunosorbent assays. Results. uNGAL levels in subjects with longer duration of inflammation were higher (115.37 ng/mL) than uNGAL levels in subjects with shorter duration of inflammation (67.87 ng/mL, P = 0.022). Difference in sNGAL and KIM-1 levels was not significant (P = 0.155 and P = 0.198, resp.). Significant difference was seen in KIM-1 excretion among groups with and without AKI (P = 0.038). KIM-1 was not able to discriminate between subjects with and without AKI (area under the curves (AUC) = 0.620, P = 0.175). Conclusions. uNGAL cannot be used for screening of the duration of inflammation during UTI. Accuracy of KIM-1 in screening of AKI development in children with UTI is low. We suggest larger studies to check the negative predictive value of KIM-1 for the development of AKI.", publisher = "Hindawi Publishing Corporation, New York", journal = "Biomed Research International", title = "Clinical Application Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 as Indicators of Inflammation Persistence and Acute Kidney Injury in Children with Urinary Tract Infection", doi = "10.1155/2013/947157" }
Petrović, S., Bogavac-Stanojević, N., Peco-Antić, A., Ivanišević, I., Kotur-Stevuljević, J., Paripović, D., Sopić, M.,& Jelić-Ivanović, Z.. (2013). Clinical Application Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 as Indicators of Inflammation Persistence and Acute Kidney Injury in Children with Urinary Tract Infection. in Biomed Research International Hindawi Publishing Corporation, New York.. https://doi.org/10.1155/2013/947157
Petrović S, Bogavac-Stanojević N, Peco-Antić A, Ivanišević I, Kotur-Stevuljević J, Paripović D, Sopić M, Jelić-Ivanović Z. Clinical Application Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 as Indicators of Inflammation Persistence and Acute Kidney Injury in Children with Urinary Tract Infection. in Biomed Research International. 2013;. doi:10.1155/2013/947157 .
Petrović, Stanislava, Bogavac-Stanojević, Nataša, Peco-Antić, Amira, Ivanišević, Ivana, Kotur-Stevuljević, Jelena, Paripović, Dušan, Sopić, Miron, Jelić-Ivanović, Zorana, "Clinical Application Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 as Indicators of Inflammation Persistence and Acute Kidney Injury in Children with Urinary Tract Infection" in Biomed Research International (2013), https://doi.org/10.1155/2013/947157 . .