High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients
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2013
Authors
Antunović, TanjaStefanović, Aleksandra

Ratković, Marina
Gledović, Branka
Gligorović-Barhanović, Najdana
Bozović, Dragica
Ivanišević, Jasmina

Prostran, Milica

Stojanov, Marina
Article (Published version)

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We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients. SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-reactive protein was assayed by a sandwich ELISA method. sUA among survivors (112.1 +/- A 13.82 mu mol/L) was significantly lower than in deceased (160.8 +/- A 16.81 mu mol/L, p lt 0.001), while SOD was higher in survivors (31.8 +/- A 6.61 kU/L) than among deceased (20.2 +/- A 3.03, p lt 0.05). Kaplan-Meier survival curves showed the greatest mortality risk in the highest tertile of basal sUA concentration (a parts per thousand yen127.11 mu mol/L, p lt 0.001), and for SOD in the lowest tertile (a parts per thousand currency sign23.83 kU/L, p lt 0.05). Our results suggest that high sUA and low SOD may predict all-cause and cardiovascular mortality in HD patients.
Keywords:
Hemodialysis / Uric acid / Superoxide dismutase / Cardiovascular risk mortalitySource:
International Urology and Nephrology, 2013, 45, 4, 1111-1119Publisher:
- Springer, Dordrecht
Funding / projects:
DOI: 10.1007/s11255-012-0233-x
ISSN: 0301-1623
PubMed: 22828740
WoS: 000322718000028
Scopus: 2-s2.0-84881478190
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PharmacyTY - JOUR AU - Antunović, Tanja AU - Stefanović, Aleksandra AU - Ratković, Marina AU - Gledović, Branka AU - Gligorović-Barhanović, Najdana AU - Bozović, Dragica AU - Ivanišević, Jasmina AU - Prostran, Milica AU - Stojanov, Marina PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1974 AB - We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients. SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-reactive protein was assayed by a sandwich ELISA method. sUA among survivors (112.1 +/- A 13.82 mu mol/L) was significantly lower than in deceased (160.8 +/- A 16.81 mu mol/L, p lt 0.001), while SOD was higher in survivors (31.8 +/- A 6.61 kU/L) than among deceased (20.2 +/- A 3.03, p lt 0.05). Kaplan-Meier survival curves showed the greatest mortality risk in the highest tertile of basal sUA concentration (a parts per thousand yen127.11 mu mol/L, p lt 0.001), and for SOD in the lowest tertile (a parts per thousand currency sign23.83 kU/L, p lt 0.05). Our results suggest that high sUA and low SOD may predict all-cause and cardiovascular mortality in HD patients. PB - Springer, Dordrecht T2 - International Urology and Nephrology T1 - High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients VL - 45 IS - 4 SP - 1111 EP - 1119 DO - 10.1007/s11255-012-0233-x ER -
@article{ author = "Antunović, Tanja and Stefanović, Aleksandra and Ratković, Marina and Gledović, Branka and Gligorović-Barhanović, Najdana and Bozović, Dragica and Ivanišević, Jasmina and Prostran, Milica and Stojanov, Marina", year = "2013", abstract = "We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients. SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-reactive protein was assayed by a sandwich ELISA method. sUA among survivors (112.1 +/- A 13.82 mu mol/L) was significantly lower than in deceased (160.8 +/- A 16.81 mu mol/L, p lt 0.001), while SOD was higher in survivors (31.8 +/- A 6.61 kU/L) than among deceased (20.2 +/- A 3.03, p lt 0.05). Kaplan-Meier survival curves showed the greatest mortality risk in the highest tertile of basal sUA concentration (a parts per thousand yen127.11 mu mol/L, p lt 0.001), and for SOD in the lowest tertile (a parts per thousand currency sign23.83 kU/L, p lt 0.05). Our results suggest that high sUA and low SOD may predict all-cause and cardiovascular mortality in HD patients.", publisher = "Springer, Dordrecht", journal = "International Urology and Nephrology", title = "High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients", volume = "45", number = "4", pages = "1111-1119", doi = "10.1007/s11255-012-0233-x" }
Antunović, T., Stefanović, A., Ratković, M., Gledović, B., Gligorović-Barhanović, N., Bozović, D., Ivanišević, J., Prostran, M.,& Stojanov, M.. (2013). High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients. in International Urology and Nephrology Springer, Dordrecht., 45(4), 1111-1119. https://doi.org/10.1007/s11255-012-0233-x
Antunović T, Stefanović A, Ratković M, Gledović B, Gligorović-Barhanović N, Bozović D, Ivanišević J, Prostran M, Stojanov M. High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients. in International Urology and Nephrology. 2013;45(4):1111-1119. doi:10.1007/s11255-012-0233-x .
Antunović, Tanja, Stefanović, Aleksandra, Ratković, Marina, Gledović, Branka, Gligorović-Barhanović, Najdana, Bozović, Dragica, Ivanišević, Jasmina, Prostran, Milica, Stojanov, Marina, "High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients" in International Urology and Nephrology, 45, no. 4 (2013):1111-1119, https://doi.org/10.1007/s11255-012-0233-x . .