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High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients

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2013
Authors
Antunović, Tanja
Stefanović, Aleksandra
Ratković, Marina
Gledović, Branka
Gligorović-Barhanović, Najdana
Bozović, Dragica
Ivanišević, Jasmina
Prostran, Milica
Stojanov, Marina
Article (Published version)
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Abstract
We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients. SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-reactive protein was assayed by a sandwich ELISA method. sUA among survivors (112.1 +/- A 13.82 mu mol/L) was significantly lower than in deceased (160.8 +/- A 16.81 mu mol/L, p lt 0.001), while SOD was higher in survivors (31.8 +/- A 6.61 kU/L) than among deceased (20.2 +/- A 3.03, p lt 0.05). Kaplan-Meier survival curves showed the greatest mortality risk in the highest tertile of basal sUA concentration (a parts per thousand yen127.11 mu mol/L, p lt 0.001), and for SOD in the lowest tertile (a parts per thousand currency sign23.83 kU/L, p lt 0.05). Our results suggest that high sUA and low SOD may predict all-cause and cardiovascular mortality in HD patients.
Keywords:
Hemodialysis / Uric acid / Superoxide dismutase / Cardiovascular risk mortality
Source:
International Urology and Nephrology, 2013, 45, 4, 1111-1119
Publisher:
  • Springer, Dordrecht
Projects:
  • Basic and Clinical Pharmacological research of mechanisms of action and drug interactions in nervous and cardiovascular system (RS-175023)

DOI: 10.1007/s11255-012-0233-x

ISSN: 0301-1623

PubMed: 22828740

WoS: 000322718000028

Scopus: 2-s2.0-84881478190
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1974
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Pharmacy

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