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dc.creatorArsenović-Ranin, Nevena
dc.creatorPerišić, Milica
dc.creatorBufan, Biljana
dc.creatorStojić-Vukanić, Zorica
dc.creatorPilipović, Ivan
dc.creatorKosec, Duško
dc.creatorLeposavić, Gordana
dc.date.accessioned2019-09-02T11:35:45Z
dc.date.available2019-09-02T11:35:45Z
dc.date.issued2013
dc.identifier.issn1535-3702
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/1976
dc.description.abstractThe study was undertaken to assess the effects of ovarian hormone withdrawal in prepubertal age on thymopoiesis in 2- (young) and 11-month-old (middle-aged) rats. In ovariectomized (Ox) rats, irrespective of age, thymic weight and cellularity were greater than in age-matched controls, but the values of both parameters exhibited the age-related decline. In addition, although thymopoietic efficiency was increased in both groups of Ox rats when compared with age-matched controls, thymopoiesis exhibited the age-related decline mirrored in the lower numbers of both CD4+ and CD8+ recent thymic emigrants in peripheral blood. This reflected the prethymic changes affecting bone marrow progenitor generation/entry and the thymic alterations encompassing the impaired progenitor progression through early pre-T-cell receptor developmental stages (defined by CD45RC/CD2 expression) and, possibly, a more pronounced decrease in the proliferation of the most mature thymocytes. Apart from the changes at thymocyte level, in Ox rats the age-related alterations in thymic stroma (substantiated in a prominent loss of thymic epithelial cells) were registered. Ovariectomy-induced changes in thymic lymphoid and epithelial component, most probably, influenced each other leading to the increase in thymic expression of interleukin-6 and interleukin-7 mRNAs along with time after ovariectomy. Collectively, the study showed that the withdrawal of ovarian hormones in prepubertal age increases the efficiency of thymopoiesis in young adult rats, but does not prevent decline in thymopoiesis occurring with age.en
dc.publisherRoyal Soc Medicine Press Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsrestrictedAccess
dc.sourceExperimental Biology and Medicine
dc.subjectovarian hormonesen
dc.subjectthymic epithelial cellsen
dc.subjectthymic cytokine expressionen
dc.subjectthymopoiesisen
dc.subjectThymic involutionen
dc.titleOvarian hormone withdrawal in prepubertal developmental stage does not prevent thymic involution in ratsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAрсеновић-Ранин, Невена; Буфан, Биљана; Стојић-Вуканић, Зорица; Перишић, Милица; Пилиповић, Иван; Косец, Душко; Лепосавић, Гордана;
dc.citation.volume238
dc.citation.issue6
dc.citation.spage641
dc.citation.epage657
dc.citation.other238(6): 641-657
dc.citation.rankM22
dc.identifier.wos000322771400006
dc.identifier.doi10.1177/1535370213489475
dc.identifier.pmid23918876
dc.identifier.scopus2-s2.0-84883758337
dc.identifier.rcubconv_2889
dc.type.versionpublishedVersion


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